بررسی اثرات دارچین بر تعداد، غلظت، مورفورلوژی و حرکت اسپرم: مرور نظام‌مند

نوع مقاله : مروری

نویسندگان

1 دانشجوی کارشناسی ارشد علوم و صنایع غذایی، کمیته تحقیقات دانشجویی، دانشکده علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 استادیار گروه تغذیه سلولی مولکولی، دانشکده علوم تغذیه و صنایع غذایی، انستیتو تحقیقات تغذیه‌ای و صنایع غذایی کشور، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 دانشجوی کارشناسی ارشد علوم و صنایع غذایی، دانشکده علوم و فناوری های پزشکی، واحد علوم و تحقیقات دانشگاه ازاد اسلامی، تهران، ایران.

10.22038/ijogi.2025.84349.6280

چکیده

مقدمه: از جمله علل ناباروری مردان، اختلالات اسپرم شامل تغییر در غلظت، زنده‌مانی، حرکت و مورفولوژی اسپرم ­ها می ­باشد. در گذشته استفاده از ترکیبات گیاهی نظیر پوست درخت دارچین به‌عنوان درمانی سنتی برای کمک به درمان مشکلات باروری محسوب می­شد. مطالعه حاضر با هدف تعیین اثر دارچین و مشتقات آن بر پارامترهای کیفی اسپرم و اثرات آن انجام شد.
روش‌کار: در این مرور نظام­ مند، کلیدواژه­ های مرتبط با ناباروری مردان، دارچین، عملکرد تولیدمثلی، اسپرماتوژنز، تعداد اسپرم، اسپرم زنده، مورفورلوژی اسپرم و حرکت اسپرم در پایگاه­ های اطلاعاتی شاملMedline ، Embase، Google Scholar، Web of Science ، Science Direct،Scopus ،Magiran ،SID ، ISC و Cochrane از ژوئن 2012 تا اکتبر 2023 به زبان­های فارسی و انگلیسی جستجو شد.
یافته ­ها: در این مرور نظام­ مند، 13 مطالعه بررسی شد. دارچین سبب بهبود پارامترهای اسپرم می­شود. مصرف دارچین باعث افزایش غلظت، زنده‌مانی، کاهش اسپرم با مورفولوژی غیرطبیعی، افزایش کیفیت اسپرم و بهبود یکپارچگی DNA اسپرم ­ها در انسان­ ها و حیوانات می­شود. استفاده از 75 میلی­ گرم بر کیلوگرم وزن بدن دارچین سبب بهبود تحرک اسپرم در موش ­های صحرایی شد. همچنین استفاده از این ماده به‌ویژه در موش­ های صحرایی مبتلا به دیابت، سبب افزایش تعداد و تحرک اسپرم شد. استفاده توأم این ماده همراه با دیگر مواد گیاهی، سبب افزایش معنی­ دار در درصد زنده‌مانی و تعداد اسپرم­ها شد.
نتیجه ­گیری: دارچین و مشتقات آن سبب افزایش غلظت، زنده‌مانی، حرکت و بهبود مورفولوژی اسپرم ­ها در مطالعات انسانی و حیوانی شده است که به‌طور بالقوه در افزایش نرخ باروری می ­تواند نقش داشته باشد. مصرف دوزهای متناسب و طولانی مدت دارچین و مشتقات آن می تواند به‌طور معنی ­داری، ویژگی­ های اسپرم را بهبود ببخشد. 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effects of cinnamon consumption on sperm count, concentration, morphology, and motility: A systematic review

نویسندگان [English]

  • Aref Adeli Mosabbeb 1
  • Ghazaleh Eslamian 2
  • Negin Majdi 3
1 M.Sc. Student of Food Sciences and Technology, Student Research Committee, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Department of Cellular and Molecular Nutrition, School of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 M.Sc. Student of Food Sciences and Technology, School of Medical Sciences and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
چکیده [English]

Introduction: Some of the causes of male infertility are sperm disorders including changes in sperm concentration, viability, motility, and morphology. Historically, traditional remedies like cinnamon bark have been utilized for treating fertility issues. The present study was conducted with aim to assess the impact of cinnamon and its derivatives on sperm quality parameters.
Methods: In this systematic review, keywords related to male infertility, cinnamon, reproductive function, spermatogenesis, sperm count, vital sperm, sperm morphology, and sperm motility were searched in English and Persian databases including Medline, Embase, Google Scholar, Web of Science, Science Direct, Scopus, Magiran, SID, ISC, and Cochrane from June 2012 to October 2023.
Results: This systematic review examined 13 studies. The use of cinnamon improves sperm parameters. Cinnamon consumption increases concentration, viability, reduces sperm with abnormal morphology, increases sperm quality, and improves sperm DNA integrity in both humans and animals. The use of 75 mg/kg body weight of cinnamon improved sperm motility in male rats. Additionally, the use of cinnamon, especially in rats with diabetes, increases sperm count and motility. The combined use of cinnamon with other herbal ingredients resulted in a significant increase in the percentage of sperm viability and count.
Conclusion: Cinnamon and its derivatives have been shown to increase sperm concentration, viability, motility, and morphology in both human and animal studies, potentially leading to increased fertility rates. Therefore, long-term and adequate doses of cinnamon and its derivatives can significantly improve sperm characteristics.

کلیدواژه‌ها [English]

  • Cinnamon
  • Sperm concentration
  • Sperm morphology
  • Sperm motility
  • Sperm viability

مراجع

  1. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS medicine 2012; 9(12):e1001356.
  2. Annapurna P, Pattnaik N. Evaluation of histopathology of endometrium in primary infertile women, a prospective five years observational study in Konaseema region of Andhra Pradesh. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 2022; 11(3):839-44.
  3. Chadwick R. Encyclopedia of applied ethics. Academic Press; 2012.
  4. Hanson BM, Kaser DJ, Franasiak JM. Male infertility and the future of in vitro fertilization. Urologic Clinics 2020; 47(2):257-70.
  5. Ghahramani F, Ghaem H. The effective factors on men infertility: a case-control study. Journal of Gorgan Medical Sciences 2005; 7:42-45.
  6. Serrano CZ, Obando AC. Diagnosis and hormonal treatment of male infertility. Actas Urológicas Españolas (English Edition) 2020; 44(5):321-7.
  7. Orhue A, Aziken M. Experience with a comprehensive university hospital-based infertility program in Nigeria. International Journal of Gynecology & Obstetrics 2008; 101(1):11-5.
  8. Akinloye O, Arowojolu AO, Shittu OB, Anetor JI. Cadmium toxicity: a possible cause of male infertility in Nigeria. Reprod Biol 2006; 6(1):17-30.
  9. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertility and sterility 2008; 90(6):2222-5.
  10. Akinola OI, Fabamwo AO, Rabiu KA, Akinoso OA. Semen quality in male partners of infertile couples in Lagos Nigeria. Int J Trop Med 2010; 5(2):37-9.
  11. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertility and sterility 2008; 90(6):2222-5.
  12. Shalaby MA, Mouneir SM. Effect of zingiber officinale roots and cinnamon zeylanicum bark on fertility of male diabetic rats. Global Veterinaria 2010; 5(6):341-7.
  13. Nojoumi M, Ashrafi M, Kouhpayehzadeh EJ. Study of couples infertility in the west of Tehran, in the year of 2000.
  14. Mosabbeb AA, Eslamian G, Habibollahi F, Hasibi K, Khoshbaf Khiabanian S, Dehghan Nayeri B. A systematic review on the effects of monosodium glutamate on quantity, concentration, morphology, and motility of sperm in male rats. The Iranian Journal of Obstetrics, Gynecology and Infertility 2024; 27(7):67-81.
  15. Kheradmand N, Nadi Z, Baazm M. The role of free radicals and antioxidants in male and female fertility disorders: review study. The Iranian Journal of Obstetrics, Gynecology and Infertility 2021; 24(2):96-106.
  16. Hafez DA. Effect of extracts of ginger goots and cinnamon bark on fertility of male diabetic rats. J Am Sci 2010; 6(10):940-7.
  17. Hemayatkhah JV, Parivar K, Forozanfar M. The effect of cinnamon extract on spermatogenesis hormonal axis of pituitary gonad in mice. Iranian Journal of Applied Animal Science2011; 1(2):99-103.
  18. Toriizuka K. Basic lecture of kampo medicine: pharmacological effect of cinnamon. Kampo Med 1998; 11:431-6.
  19. Sambaiah K, Srinivasan K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Food/Nahrung 1991; 35(1):47-51.
  20. Thomas J, Duethi PP. 11 - Cinnamon. In: Peter KV, editor. Handbook of Herbs and Spices: Woodhead Publishing; 2001. p. 143-53.
  21. Kamath JV, Rana AC, Roy Chowdhury A. Pro‐healing effect of Cinnamomum zeylanicum bark. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 2003; 17(8):970-2.
  22. Robertshawe P. Skidmore-Roth L. Mosby's Handbook of Herbs and Natural Supplements. Journal of the Australian Traditional-Medicine Society 2007; 13(4):241-2.
  23. Ruberto G, Baratta MT, Deans SG, Dorman HD. Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils. Planta medica 2000; 66(08):687-93.
  24. Parameswari R, Babujanarthanam R, Sridharan TB, Yogesh T, Nithyanandan S, Gomathi R, et al. Cinnamon mediated-zinc oxide nanoparticles and its cryogenic effect on SARS-CoV-2 recovered HTPI patients–An in vitro cum pilot study. Materials Today: Proceedings 2023.
  25. Khaki A. Effect of Cinnamomum zeylanicumon on Spermatogenesis. Iranian Red Crescent Medical Journal 2015; 17(2).
  26. Fathiazad F, Khaki A, Nouri M, Afshin KA. Effect of Cinnamon Zeylanicum on serum Testosterone and anti-oxidants levels in Rats. International Journal of Women’s Health and Reproduction Sciences 2014; 1(1):29-35.
  27. Rabeh NM. Effect of halawa tahinia alone or with ginger and cinnamon on sex hormones in adult male rats. International Journal of Nutrition and Food Sciences 2016; 5(3):211-9.
  28. Ahmadian M, Salari R, Noras MR, Ahmadnia H, Esmaily H, Bahrami-Taghanaki HR. Comparison of the Effect of Carob Capsule and acupuncture on Sperm Motility, in Idiopathic Male Infertility: A Randomised Controlled Trial. Journal of Herbal Medicine 2023; 42:100805.
  29. Parameswari R, Babujanarthanam R, Sridharan TB, Yogesh T, Nithyanandan S, Gomathi R, et al. Cinnamon mediated-zinc oxide nanoparticles and its cryogenic effect on SARS-CoV-2 recovered HTPI patients–An in vitro cum pilot study. Materials Today: Proceedings 2023.
  30. Alizadeh H, Khaki A, Farzadi L, Nouri M, Ahmadi AY, Seyedghiasi G, et al. The therapeutic effects of a medicinal plant mixture in capsule form on catalase levels in the semen of men with oligospermia. Crescent Journal of Medical and Biological Sciences 2015; 2(1):6-9.
  31. Chegini R, Soleimani P, Sadeghi M, Mohammad Yosef R, Zafari F. Investigating the effect of fennel and cinnamon combined extract on spermatogenesis and testis tissues in busulfan induced infertile rats. Journal of Applied Biotechnology Reports 2019; 6(3):96-100.
  32. Ibrahim AA, Al-Shathly MR. Herbal blend of cinnamon, ginger, and clove modulates testicular histopathology, testosterone levels and sperm quality of diabetic rats. Int J Pharm Sci Rev Res 2015; 30(2):95-103.
  33. Khaki A. Effect of Cinnamomum zeylanicumon on Spermatogenesis. Iranian Red Crescent Medical Journal 2015; 17(2).
  34. Khaki A, Khaki AA, Hajhosseini L, Golzar FS, Ainehchi N. The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats. African Journal of Traditional, Complementary and Alternative Medicines 2014; 11(4):1-8.
  35. Mahdi AK. Cinnamon Bark Extract Improved the Semen Quality of Male Albino Mice. Journal of MadentAlelemCollege (JMAC) 2013; 5(1).
  36. Mohammed AQ, Amin AM. Effects of supplementation cinnamon cassia and zingiber officinale powder on reproductive performance of broiler breeder male. Plant Arch 2019; 19:567.
  37. Sánchez-Rubio F, Fernández-Santos MR, Castro-Vázquez L, García-Álvarez O, Maroto-Morales A, Soler AJ, et al. Cinnamtannin B-1, a novel antioxidant for sperm in red deer. Animal reproduction science 2018; 195:44-52.
  38. Sariözkan S, Türk G, Güvenç M, Yüce A, Özdamar S, Cantürk F, et al. Effects of cinnamon (C. zeylanicum) bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. Nutrition and cancer 2016; 68(3):481-94.
  39. Soleimani P, Chegini R, Sadeghi M, Yonesi F, Zafari F. Evaluation of hydroalcoholic extract of cinnamon effect on testicular tissue and fertility of busulfan-induced oligo-spermic model rats. Journal of Babol University of Medical Sciences 2019; 21(1):196-200.
  40. Yüce A, Türk G, Çeribaşi S, Sönmez M, Çiftçi M, Güvenç M. Effects of cinnamon (C innamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality. Andrologia 2013; 45(4):248-55.
  41. Boroujeni SN, Malamiri FA, Bossaghzadeh F, Esmaeili A, Moudi E. The most important medicinal plants affecting sperm and testosterone production: A systematic review. JBRA assisted reproduction 2022; 26(3):522.
  42. Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant. Evidencebased complementary and alternative medicine: eCAM 2014.
  43. Elgawish RA, Abdelrazek HM. Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats. Toxicology Reports 2014; 1:795-801.
  44. Yüce A, Türk G, Çeribaşı S, Güvenç M, Çiftçi M, Sönmez M, et al. Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride‐induced damages on the male reproductive system. Andrologia 2014; 46(3):263-72.
  45. Patil M, Choudhari AS, Pandita S, Islam MA, Raina P, Kaul-Ghanekar R. Cinnamaldehyde, cinnamic acid, and cinnamyl alcohol, the bioactives of Cinnamomum cassia exhibit HDAC8 inhibitory activity: an in vitro and in silico study. Pharmacognosy Magazine 2017; 13(Suppl 3):S645.
  46. Walke G, Gaurkar SS, Prasad R, Lohakare T, Wanjari M. The impact of oxidative stress on male reproductive function: Exploring the role of antioxidant supplementation. Cureus 2023; 15(7): e42583.
  47. Pagliari S, Forcella M, Lonati E, Sacco G, Romaniello F, Rovellini P, et al. Antioxidant and anti-inflammatory effect of cinnamon (Cinnamomum verum J. Presl) bark extract after in vitro digestion simulation. Foods 2023; 12(3):452.
  48. Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. Journal of reproduction & infertility 2015; 16(3):123-9.
مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 12
اسفند 1403
صفحه 79-94

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