بررسی مقایسه‌ای سیاه‌دانه، منستروگل و مفنامیک اسید بر پس‌درد زایمان: یک کارآزمایی بالینی تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران.

2 کارشناس ارشد مامایی، مرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران.

3 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران.

4 استادیار گروه اپیدمیولوژی و آمار، مرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران.

10.22038/ijogi.2024.82966.6220

چکیده

مقدمه: پس‏درد یا انقباضات رحمی، یکی از مشکلات شایع دوران پس از زایمان است که بر کیفیت زندگی مادران تأثیر بسزایی دارد. با توجه به عوارض جانبی ناشی از مصرف داروهای شیمیایی و همچنین اضطراب و نگرانی مادران از اثرات دارویی داروها برای خود و نوزادانشان، امروزه تمایل مادران به استفاده از داروهای گیاهی جهت تسکین پس ‏درد زایمان افزایش یافته ‏است. مطالعه حاضر با هدف مقایسه تأثیر سیاه­دانه و منستروگل با مفنامیک‏اسید بر پس‏درد زایمان انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی و سه‌سوکور در سال 1401-1400 بر روی 60 زن چندزای مراجعه کننده به زایشگاه ولی عصر (عج) شهرستان بیرجند که زایمان طبیعی کرده و از پس‌درد زایمان شکایت داشتند؛ انجام گرفت. افراد به‌صورت تصادفی در سه گروه کپسول سیاه­دانه، منستروگل و مفنامیک‏اسید قرار گرفتند و هر 6 ساعت به‌مدت 24 ساعت کپسول مصرف کردند. شدت درد قبل از هر بار مصرف و یک ساعت بعد از آن اندازه‌گیری شد. تجزیه و تحلیل داده ­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 22) و آزمون های آنالیز واریانس، کای‏دو، تی‏ زوجی و تعقیبی بن‏فرونی انجام گرفت. میزان p کمتر از 05/0 معنی‏دار در نظر گرفته شد.
یافته ­ها: میانگین نمره شدت درد قبل و بعد از مداخله در نوبت اول در سه گروه با یکدیگر اختلاف معناداری نداشت (05/0<p)، در حالی‌که بر اساس نتایج آزمون آنالیز واریانس، شدت درد در سه گروه در نوبت دوم بعد از مداخله (02/0=p)، نوبت سوم بعد از مداخله (002/0=p) و در نوبت چهارم بعد از مداخله (05/0>p) دارای اختلاف معناداری بود و در گروه سیاه­دانه و منستروگل میزان شدت درد کمتر از گروه مفنامیک ‏اسید بود، همچنین میزان مصرف مسکن­ های اضافی نیز کمتر بود.
نتیجه­ گیری: سیاه­دانه و منستروگل می­ توانند به‌عنوان یک داروی گیاهی مؤثر بر کاهش شدت درد پس از زایمان مورد استفاده قرار گیرند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effects of Nigella sativa, menstrogel, and mefenamic acid on postpartum pain: a randomized clinical trial

نویسندگان [English]

  • Mahla Salarfard 1
  • Nahid Barati 2
  • Nahid Ghanbarzadeh 3
  • Gholamreza Sharifzadeh 4
1 M.Sc. in Midwifery, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.
2 M.Sc. in Midwifery, Social Determinants of Health Research Center, School of Health, Birjand University of Medical Sciences, Birjand, Iran.
3 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
4 Assistant professor, Department of Epidemiology and Statistics, Social Determinants of Health Research Center, School of Health, Birjand University of Medical Sciences, Birjand, Iran.
چکیده [English]

Introduction: Postpartum pain or uterine contractions is one of the common problems of the postpartum period, which has a significant impact on the quality of life of mothers. Considering the side effects caused by the use of chemical drugs, as well as mothers' anxiety and worry about the medicinal effects of drugs for themselves and their babies, today mothers' desire to use complementary medicine to relieve postpartum pain has increased. The present study was conducted with aim to compare the effect of Nigella sativa vs. menstrogel and mefenamic acid on postpartum pain.
Methods: This triple-blind clinical trial study was conducted in 2021-2022 on 60 multiparous women referring to Walie Asr maternity hospital in Birjand city who gave birth naturally and complained of postpartum pain. The women were randomly assigned to three groups of Nigella sativa, menstrogel, and mefenamic acid capsules and they took capsules every 6 hours for 24 hours. Pain intensity was measured before each dose and one hour later. Data were analyzed by SPSS software (version 22) and ANOVA, chi-square, paired t-test, post hoc Benferroni tests. P<0.05 was considered significant.
Results: The mean score of pain intensity before and after the intervention in the first round did not differ significantly in the three groups (p>0.05), while the results of the analysis of variance showed that the pain intensity has a significant difference in the three groups in the second round after the intervention (p=0.02), the third round after the intervention (p=0.002) and the fourth round after the intervention (p<0.05), and the intensity of pain was less in the Nigella sativa and menstrogel group than the mefenamic acid group, and the consumption of additional painkillers was also lower.
Conclusion: Nigella sativa and menstrogel can be used as an effective herbal medicine to reduce the intensity of postpartum pain.

کلیدواژه‌ها [English]

  • Mefenamic acid
  • Nigella sativa
  • Pain
  • Postnatal care

مراجع

  1. Mehravar S, Akbari SA, Nasiri M, Mojab F, Abbasi H. The effect of Triticum sativum (wheat) germ on postpartum pain: A double-blind clinical trial. Avicenna Journal of Phytomedicine 2021; 11(6):576.
  2. Gosiewski C, Lavigne A, Macomber L, McDaniel E, Ruttum D, Miranda SR. Implementation of a pain-management plan in a small hospital to decrease postpartum opioid use. Journal of Obstetric, Gynecologic & Neonatal Nursing 2019; 48(3):S18-9.
  3. Cunningham FG, Leveno KJ, Dashe JS, Hoffman BL, Spong CY, Casey BM, et al. Williams Obstetrics. 26nd ed. New York: McGraw-Hill Education; 2022.
  4. Maleki SM, Heydarpour S, Nikrai R, Heydarpour F. The comparison of effectiveness of acupressure on Spleen 6 and Hugo points on the severity of postpartum pain: A randomized clinical trial. Health Science Reports 2024; 7(7):e2265.
  5. Bardar MM, Karimi FZ, Mazloum SR, Salari R. The impact of sesame oil on postpartum after-pain in multiparous women: a randomised, triple-blind, placebo-controlled clinical trial. Journal of Herbal Medicine 2024; 45:100885.
  6. Kheiriyat F, Tadayon Najafabadi M, Mousavi P, Haghighizadeh H, Namjuyan F. Effect of Dill essence and mefenamic acid on postpartum pain. The Iranian Journal of Obstetrics, Gynecology and Infertility 2016; 19(4):8-16.
  7. Maghalian M, Alikamali M, Nabighadim M, Mirghafourvand M. The effects of warm perineal compress on perineal trauma and postpartum pain: a systematic review with meta-analysis and trial sequential analysis. Archives of Gynecology and Obstetrics 2024; 309(3):843-69.
  8. Ozgoli G, Khodadie A, Mojab Z, Jambarsang S, Sheikhan F, Taleb S. Comparison of efficacy between herbal capsule of anise and mefenamic acid on postpartum after-pain. Journal of Medicinal Plants 2017; 16(62):38-45.
  9. Chananeh M, Janati Ataei P, Dolatian M, Mojab F, Nasiri M. Effects of the combination of nigella sativa and mefenamic acid and mefenamic acid alone on the severity of postpartum pain in multiparous women: a double-blind clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility 2018; 21(4):62-71.
  10. Deussen AR, Ashwood P, Martis R, Stewart F, Grzeskowiak LE. Relief of pain due to uterine cramping/involution after birth. Cochrane database of systematic reviews 2020(10).
  11. Abouei Mehrizi M, Heshmat R, Reza Nezhad P, Nasiri M, Tabatabaie Bafghi A, Javaheri A, et al. The effect of 3-Liver pressure point on postpartum severity of pain: Randomized clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility 2020; 22(12):69-79.
  12. Parsa L, Ozgoli G. A systematic on the medicinal plants used in the treatment of postpartum pain in Iran. The Iranian Journal of Obstetrics, Gynecology and Infertility 2017; 20(5):84-96.
  13. Foroughi P, Zaheri F, Shahoie R. Comparative study of the effect of fennel capsules and ibuprofen tablets on postpartum pains in multiparous women. Scientific Journal of Nursing, Midwifery and Paramedical Faculty 2021; 6(4):1-8.
  14. Keshavarzinejad M, Heydari M. Effect of Hydro-Alcoholic Extract of Capsella Bursa Pastoris on Postpartum Pain and Volume of Bleeding, a Randomized Clinical Trial. Journal of Health and Care 2023; 24(4):331-41.
  15. Begley CM, Gyte GM, Devane D, McGuire W, Weeks A, Biesty LM. Active versus expectant management for women in the third stage of labour. Cochrane Database Syst Rev 2019; 2(2):CD007412.
  16. Afravi S, Abbaspoor Z, Montazeri S, Cheraghian B. The effect of Hugo point pressure on postpartum pain in multiparous women. Family Medicine & Primary Care Review 2019(1):7-11.
  17. Fahey JO. Best practices in management of postpartum pain. The Journal of perinatal & neonatal nursing 2017; 31(2):126-36.
  18. Conrad P, Adams C. The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman–a pilot study. Complementary therapies in clinical practice 2012; 18(3):164-8.
  19. Kheiriyat F, Najafabadi MT, Mousavi P, Haghighizadeh MH, Namjoyan F. The comparison of the effect of dill extract and mefenamic acid on the duration of the postpartum pain: a randomized clinical trial. Medical Sciences Journal of Islamic Azad University 2021; 31(1):88-96.
  20. Modanlo M, Taraghi Z, Jokar A, Zamaniyan M, Zakizad Abkenar M. Effect of Topical Black Seed Oil on Urinary Incontinence in Old Women: A Double-Blind Clinical Trial. Journal of Mazandaran University of Medical Sciences 2022; 32(214):102-12.
  21. Hannan MA, Rahman MA, Sohag AA, Uddin MJ, Dash R, Sikder MH, et al. Black cumin (Nigella sativa L.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients 2021; 13(6):1784.
  22. Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, et al. Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn. Pharmacological research 2018; 129:357-64.
  23. Jafarnejad F, Mohanazadeh Falahieh F, Rakhshandeh H, Shakeri MT. Comparison of the effect of nigella sativa and mefenamic acid on menstrual hemorrhage in the students with primary dysmenoreha. The Iranian Journal of Obstetrics, Gynecology and Infertility 2016; 18(185):10-5.
  24. Zeraati F, Shobeiri F, Nazari M, Araghchian M, Bekhradi R. Comparative evaluation of the efficacy of herbal drugs (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea. Iranian journal of nursing and midwifery research 2014; 19(6):581-4.
  25. Nazari S, Nazari S, Shayan A, Shobeiri F, Jenabi E. Comparison of the effect menstrugloe capsule and vitamin e on the intensity of primary dysmenorrhea based on multi-dimensional speech scale. The Iranian Journal of Obstetrics, Gynecology and Infertility 2018; 21(9):42-9.
  26. Nasri S, Shahi SadrAbadi F, Kamalinejhad M, Rabbani T. Investigation of the possible mechanism of antinociceptive effect of Apium graveolens hydroalcoholic fruits extract. Journal of Arak University of Medical Sciences 2012; 15(5):66-75.
  27. Shadipour M, Simbar M, Salamzadeh J, Nasire N. A comparative study on the effects of Menstrogol and Mefenamic acid on postpartum after-pain. Iranian South Medical Journal 2014; 16(6):401-9.
  28. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual analog scale for pain (vas pain), numeric rating scale for pain (nrs pain), mcgill pain questionnaire (mpq), short‐form mcgill pain questionnaire (sf‐mpq), chronic pain grade scale (cpgs), short form‐36 bodily pain scale (sf‐36 bps), and measure of intermittent and constant osteoarthritis pain (icoap). Arthritis care & research 2011; 63(S11):S240-52.
  29. Chang SR, Chen KH, Lin HH, Chao YM, Lai YH. Comparison of the effects of episiotomy and no episiotomy on pain, urinary incontinence, and sexual function 3 months postpartum: a prospective follow-up study. International journal of nursing studies 2011; 48(4):409-18.
  30. Mirmolaei ST, Olfatbakhsh A, Huseini HF, Leyli EK, Moridiani AS. The effect of Nigella Sativa syrup on the relief of cyclic mastalgia: a triple-blind randomized clinical trial. HAYAT 2017; 23(1):33-43.
مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 11
بهمن 1403
صفحه 51-61

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