تأثیر ترکیبات حاوی میواینوزیتول بر پارامترهای اسپرم و افزایش میزان باروری در مردان: مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 کارشناسی ارشد، گروه مامایی، دانشکده پرستاری و مامایی، علوم پزشکی مشهد، دانشگاه آزاد اسلامی، مشهد، ایران.

2 کارشناسی ارشد ، گروه مامایی، دانشکده پرستاری و مامایی، علوم پزشکی مشهد، دانشگاه آزاد اسلامی، مشهد، ایران.

10.22038/ijogi.2024.80839.6125

چکیده

مقدمه: ناباروری یک مسئله جهانی است که به ناتوانی در باروری پس از رابطه جنسی منظم و بدون محافظت اشاره دارد. استرس اکسیداتیو از جمله عواملی است که می‌تواند به ناتوانی در تولید اسپرم و ناباروری مردان منجر شود. اینوزیتول با کاهش استرس اکسیداتیو می‌تواند به بهبود باروری مردان کمک کند. این مرور سیستماتیک با هدف بررسی تأثیرات مکمل‌های حاوی اینوزیتول بر پارامترهای اسپرم و افزایش باروری مردان انجام شد.
روش‌کار: جستجوی سیستماتیک در پایگاه‌های اطلاعاتی Magiran، PubMed، Scopus، Web of Science، Cochrane، SID و Google Scholar با استفاده از کلمات کلیدی فارسی (ناباروری، پارامترهای اسپرم، اینوزیتول، باروری مردان، تحرک اسپرم و انگلیسی infertility، inositol، male fertility، oligoasthenospermia، motility sperm تا اکتبر سال 2024 با استفاده از عملگرهای بولین (AND و OR) انجام شد. مقالات بر اساس معیارهای ورود و خروج از طریق بررسی عنوان، چکیده و متن کامل انتخاب و ارزیابی شدند.
یافته­ ها: از بین 23492 مقاله شناسایی شده پس از بررسی عنوان و چکیده، 192 مقاله وارد مطالعه شدند و 10 مقاله برای تحلیل نهایی انتخاب شدند. داده‌های مطالعات انجام‌ شده در دوره 2024-2015 و با مشارکت 778 نفر، اثرات متنوعی از مصرف مکمل‌های حاوی اینوزیتول در دسته‌های مختلف ناباروری نشان دادند. بهبود‌ معناداری در حجم مایع منی، تعداد کل اسپرم، تحرک پیشرونده و غلظت اسپرم مشاهده شد.
نتیجه­ گیری: مکمل‌های حاوی اینوزیتول می‌توانند به‌عنوان یکی از راهکارهای مدیریت ناباروری مردان مورد استفاده قرار گیرند؛ به‌طوری‌که ممکن است بهبودی در پارامترهای اسپرمی را به ارمغان آورند. نیاز به تحقیقات بیشتری برای اعتبارسنجی این یافته‌ها و بررسی مکانیسم‌های دقیق‌تر وجود دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of myo-inositol containing compounds on sperm parameters and increased fertility in men: A systematic review

نویسندگان [English]

  • Dina Abadi Bavil 1
  • Fahimeh Tahoonian Golkhatmy 2
1 M.Sc. in Midwifery, Department of Midwifery, School of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
2 M.Sc. in Midwifery, Department of Midwifery, School of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
چکیده [English]

Introduction: Infertility is a global issue referring to the inability to conceive after regular unprotected sexual intercourse. Oxidative stress is among the factors which can lead to inability in sperm production and male infertility. Inositol by reducing oxidative stress can aid in improving male fertility. This systematic review was conducted with aim to investigate the effects of inositol-containing supplements on sperm parameters and enhancing male fertility.
Methods: A systematic search was conducted on databases including Magiran, PubMed, Scopus, Web of Science, Cochrane, SID, and Google Scholar using Persian and English keywords (infertility, inositol, male fertility, sperm motility, oligoasthenospermia) up to October 2024 with Boolean operators (AND and OR). Articles were selected and evaluated based on inclusion and exclusion criteria through evaluating title, abstract, and full-text.
Results: Out of 23492 identified articles, after reviewing the title and abstract, 192 articles were included in the study and 10 articles were selected for the final analysis. Data from studies conducted between 2015 and 2024, involving 778 participants, showed varied effects of inositol supplements across different categories of infertility. Significant improvements were observed in semen volume, total sperm count, progressive motility, and sperm concentration.
Conclusion: Inositol-containing supplements can be used as a management strategy for male infertility, so that they potentially improve sperm parameters. Further research is necessary to validate these findings and explore underlying mechanisms more comprehensively.

کلیدواژه‌ها [English]

  • Infertility
  • Inositol
  • Male fertility
  • Sperm motility

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 9
آذر 1403
صفحه 81-98

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