نقش میکروبیوتا بر سلامت باروری زنان: مکانیسم‌های دفاعی، پاتوژنز و اهمیت آن در چسبندگی رحم- مرور سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی کارشناسی ارشد فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 دکترای میکروب‌شناسی، مدیریت امور آزمایشگاه‌های معاونت درمان، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 استاد گروه فیزیولوژی، مرکز تحقیقات سندرم متابولیک، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

10.22038/ijogi.2024.77392.5968

چکیده

مقدمه: حدود 9% از کل میکروبیوتا بدن، میکروبیوتای سیستم تولید مثل را تشکیل می­ دهد. میکروبیوتای دستگاه تناسلی زنان، نقش مهمی در سلامت و بیماری دارند. عدم تعادل در میکروبیوتای واژن، منجر به اختلالاتی از جمله چسبندگی داخل رحمی (IUA) می­ شود که نشانه‌­های بالینی معمول آن شامل آمنوره، ناباروری و درد لگنی است. مطالعه حاضر با هدف بررسی پژوهش­ هایی که نقش میکروبیوتای رحم را در سیستم دفاعی بدن، بیماری‌های مختلف و به‌خصوص نقش آن در پاتوژنز ایجاد چسبندگی رحم مطالعه کرده‌اند، انجام شد.
روش‌کار: در این مقاله مروری، مطالعات مربوط به میکروبیوتای واژن و چسبندگی ­های داخل رحمی در پایگاه داده‌های PubMed ،Scopus ،EMBASE ،Web of Knowledge ، SID و همچنین سیستم بررسی واژگان (Mesh) با استفاده از کلمات کلیدیVaginal Microbiota ،Uterine microbiota ،Intrauterine adhesions و Dysbiosis مورد جستجو قرار گرفتند.
یافته­ ها: میکروبیوتا از طریق مکانیسم­ های متعدد، نقش مهمی در فرآیندهای فیزیولوژیکی انسان از جمله متابولیسم بدن، التهاب، سیستم ایمنی و ... دارد. لاکتوباسیلوس، میکروبیوتای غالب دستگاه تناسلی، به حفظ محیط اسیدی که برای باکتری‌های مضر نامناسب است، کمک می‌کند. ترکیب میکروبیوتا می ­تواند تحت تأثیر عواملی مانند سن و هورمون تغییر کند و هر عاملی مانند استفاده غیرمنطقی آنتی‌بیوتیک‌ها، تعادل میکروبیوتا را مختل کرده و منجر به بیماری­ هایی مانند چسبندگی رحم شود.
نتیجه­ گیری: عدم تعادل در میکروبیوتای بدن از جمله در دستگاه تناسلی می‌تواند منجر به عوارضی مانند چسبندگی رحم شود. درک کامل مکانیسم و سازوکار عملکرد میکروبیوتای دستگاه تناسلی در ایجاد، درمان و پیشگیری از بیماری‌های زنان، نیازمند مطالعات بالینی بیشتری در آینده می‌باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Role of Microbiota on Women's Reproductive Health: Defense Mechanisms, Pathogenesis, and Its Importance in Uterine Adhesion: A Systematic Review

نویسندگان [English]

  • Elaheh Eshtad 1
  • Atieh Yaghoubi 2
  • Majid Khazaei 3
1 M.Sc. Student of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Ph.D of Microbiology, Management Affairs of Laboratories of Vice President of Treatment, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Professor, Department of Physiology, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: About 9% of the total microbiota of the body is the microbiota of the reproductive system. The microbiota of the female genital tract plays an important role in health and disease. An imbalance of vaginal microbiota leads to disorders such as intrauterine adhesions (IUA) that its common clinical symptom includes amenorrhea, infertility, and pelvic pain. The present study was conducted with aim to investigate the role of uterine microbiota in the defense system, different diseases, and pathogenesis of uterine adhesions.
Methods: In this review article, studies related to vaginal microbiota and intrauterine adhesions were searched in PubMed, Scopus, EMBASE, Web of Knowledge, and MeSH databases using keywords of Vaginal Microbiota, Uterine microbiota, Intrauterine adhesions, and Dysbiosis.
Results: Microbiota through different mechanisms affects human physiological processes such as metabolism, infection, and immune system. Lactobacillus is the dominant microbiota of the genital tract, which creates an acidic environment that prevents the growth of harmful bacteria. The composition of microbiota can change under the influence of factors such as age and hormones, and any factor such as irrational use of antibiotics disturbs the balance of microbiota and leads to diseases such as uterine adhesions.
Conclusion: An imbalance in the bocy microbiota including the reproductive system can cause complications such as uterine adhesions. A complete understanding of the mechanism of the microbiota of the reproductive system in the development, treatment and prevention of women's diseases requires more clinical studies in the future.

کلیدواژه‌ها [English]

  • Dysbiosis
  • Intrauterine Adhesion
  • Microbiota

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 8
آبان 1403
صفحه 81-100

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