اثرات دکسمدتومیدین بر روی ایلئوس در جراحی زنان: مروری سیستماتیک و متاآنالیز

نوع مقاله : مروری

نویسندگان

1 استادیار گروه بیهوشی، مرکز تحقیقات بیهوشی، مراقبت ویژه و کنترل درد، دانشکده پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

2 استادیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

3 استادیار گروه جراحی عمومی، دانشکده پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

4 دانشیار گروه بیهوشی، مرکز تحقیقات بیهوشی، مراقبت ویژه و کنترل درد، دانشکده پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

5 کارشناس ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

6 استادیار گروه جراحی، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

7 استادیار گروه بیهوشی و مراقبت‌های ویژه، دانشکده پزشکی، دانشگاه علوم پزشکی گلستان، گرگان، ایران.

10.22038/ijogi.2024.79425.6068

چکیده

مقدمه: در حالی که مطالعات مروری سیستماتیک متعددی بر روی اثرات و عوارض جانبی دکسمدتومیدین در جراحی­ های زنان انجام شده است، هیچ مرور قبلی، اثرات آن را بر بروز ایلئوس ارزیابی نکرده است. بنابراین مطالعه مروری حاضر با هدف جمع‌آوری داده‌های مربوط به این وضعیت پزشکی در پیشینه پژوهش دکسمدتومیدین و جراحی زنان انجام شد.
روش‌کار: در این مطالعه مرور نظام‌مند و متاآنالیز، طبق بیانیه PRISMA، پایگاه‌های اطلاعاتی PubMed، Scopus، Embase، Web of Science، CINAHL، کتابخانه کاکرین، ClinicalTrials.gov، پلتفرم ثبت کارآزمایی‌های بالینی بین‌المللی (ICTRP)WHO ، پایگاه داده‌های علوم پزشکی ایران (IranMedex)، پایگاه اطلاعات علمی SID و موتور جستجوگر گوگل اسکالر با استفاده از مجموعه‌ای از کلمات کلیدی در مورد ایلئوس، جراحی­های زنان و زایمان و دکسمدتومیدین به زبان فارسی و انگلیسی و بدون محدودیت زمانی مورد جستجو قرار گرفتند. داده‌ها استخراج و نتایج مربوط به بازیابی عملکرد روده توسط مدل‌های اثر تصادفی کوهن ادغام شد.
یافته­ ها: در مجموع 9 مطالعه دارای معیارهای واجد شرایط بودند. نتایج متاآنالیز با مقایسه زمان بهبود عملکرد روده پس از جراحی بین دکسمدتومیدین و شاهد نشان داد که در گروه‌های مصرف کننده دکسمدتومیدین نسبت به گروه کنترل، زمان کمتری برای بازیابی عملکرد روده پس از جراحی وجود دارد (اندازه اثر: 97/1- بازه اطمینان 95%: 242/0- تا 707/3-).
نتیجه ­گیری: دکسمدتومیدین به بازیابی عملکرد روده پس از جراحی­ های زنان کمک می­ کند؛ با این‌حال تحقیقات بیشتر برای اطمینان از نتایج برای کاربرد بالینی موردنیاز است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effects of dexmedetomidine on ileus in gynecology surgery: A systematic review and meta-Analysis

نویسندگان [English]

  • Tayyebeh Zarei 1
  • Farideh Mogharab 2
  • Mehrdad Sayadinia 3
  • Majid Vatankhah 4
  • Pourya Adibi 1
  • Mehrdad Malekshoar 4
  • Bibi Mona Razavi 1
  • Samira Katebi 5
  • Lohrasb Taheri 6
  • Mansour Deilami 7
1 Assistant Professor, Department of Anesthesiology, Anesthesiology and Pain Management Research Center, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Assistant professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3 Assistant Professor, Department of General Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
4 Associate Professor, Department of Anesthesiology, Anesthesiology and Pain Management Research Center, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
5 M.Sc. of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
6 Assistant Professor, Department of Surgery, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
7 Assistant Professor, Department of Anesthesiology and Critical Care, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
چکیده [English]

Introduction: While multiple systematic review studies are performed on the effects and side effects of the dexmedetomidine in gynecology surgeries, no previous review has evaluated its effects on the occurrence of the ileus. So, this review study was conducted with aim to collect data related to this medical entity in literature of dexmedetomidine and gynecology surgery.
Methods: In this systematic review and meta-analysis, based on PRISM, databases of PubMed, Scopus, Embase, Web of Science, CINAHL, Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), Iranian Database of Medical Sciences (IranMedex), and Scientific Information Database (SID) were searched using set of keywords about ileus, gynecology surgeries, and Dexmedetomidine in Persian and English language without time limit. Data were extracted and outcomes regarding the bowel function recovery were pooled by Cohen’s random effect models.
Results: A total of 9 studies met the eligibility criteria. The meta-analysis results comparing the time of recovery of bowel function after surgery between Dexmedetomidine and control groups showed that there is a less time to recover the bowel function in DEX groups compared to controls (the total effect size of -1.974, 95% CI: -0.242 to -3.707).
Conclusion: Dexmedetomidine helps to restore bowel function after gynecological surgeries; However, further research is needed to confirm the results for clinical application.

کلیدواژه‌ها [English]

  • Bowel function
  • Dexmedetomidine
  • Meta-analysis
  • Postoperative recovery
  • Surgery outcomes
  • Systematic review

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مجله زنان، مامایی و نازایی ایران
دوره 28، شماره 2
اردیبهشت 1404
صفحه 70-81

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