نوع مقاله : اصیل پژوهشی
نویسندگان
1 (2) دستیار گروه زنان و مامایی، مرکز پزشکی آموزشی-درمانی امام حسین (ع)، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
2 استاد گروه زنان و مامایی، مرکز پزشکی آموزشی-درمانی امام حسین (ع)، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Considering the relatively high importance and complications of endometrial malignancies, especially during menopause, and considering that the role of endocrine hormones was not fully clarified, this study aims to determine the relationship between estradiol levels and the characteristics of Clinical study of postmenopausal bleeding women with endometrial malignancy was performed.
Methods: This analytical-cross-sectional study was conducted on 54 patients with postmenopausal bleeding suffering from endometrial malignancy who referred to Imam Hossein (AS) hospital in 2023, according to the inclusion criteria, using the full enumeration method. Demographic, clinical and serum estradiol levels of patients were collected.
Results: Serum estradiol level was 26.80 ± 15.77 pg/ml (median: 26.30, lowest: 6.7 and highest: 124.9 pg/ml). In the normal estradiol group compared to abnormal estradiol, the prevalence of endometrial thickness ≥ 4 mm (0.73 vs. 100% and p = 0.018) and family history of uterine malignancy (35.2 vs. 83.8% and p = 0.026) p = 0/0), was less. The most common type of pathology in both groups was grade 1 endometrioid adenocarcinoma, and this difference was not significant (p = 0.780).
Conclusion: Considering the relationship between estradiol level with high thickness of the endometrium and family history of uterine malignancy, further investigation of the role of this hormone in endometrial malignancies is suggested.
Keywords: Endometrial malignancy, estradiol, post-menopause, abnormal uterine bleeding
کلیدواژه‌ها [English]
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