ارتباط سطح استرادیول با ویژگی‌های بالینی زنان یائسه مبتلا به بدخیمی‌های آندومتر دارای خونریزی غیرطبیعی رحمی

نوع مقاله : اصیل پژوهشی

نویسندگان

1 استاد گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دستیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: با توجه به اهمیت و عوارض نسبتاً بالای بدخیمی­ های آندومتر خصوصاً در دوران یائسگی و با توجه به اینکه نقش هورمون­ های درون­ ریز به‌طور کامل روشن نشده است، مطالعه حاضر با هدف تعیین ارتباط سطح استرادیول با ویژگی­ های بالینی زنان دارای خونریزی پس از یائسگی مبتلا به بدخیمی­ های آندومتر انجام شد.
روش‌کار: این مطالعه­ تحلیلی- مقطعی در سال 1402 بر روی 54 بیمار با خونریزی پس از یائسگی مبتلا به بدخیمی آندومتر مراجعه­ کننده به بیمارستان امام حسین (ع) تهران انجام شد. اطلاعات دموگرافیک، بالینی (علائم و نشانه ­ها) و سطح سرمی استرادیول بیماران گردآوری شد. تجزیه و تحلیل داده­ ها با استفاده از نرم ­افزار آنالیز آماری SPSS (نسخه 23) و آزمون­ های آماری تی، من­ ویتنی و کای دو انجام شد. میزان p کم­تر از 05/0 معنی­ دار در نظر گرفته­ شد.
یافته­ ها: سطح استرادیول سرمی، برابر 77/15±80/26 پیکوگرم بر میلی­لیتر بود. 37 نفر (5/68%) دارای سطوح طبیعی و 17 نفر (5/31%) دارای سطوح غیرطبیعی استرادیول بودند. در گروه استرادیول طبیعی نسبت به استرادیول غیرطبیعی، شیوع ضخامت آندومتر بیشتر یا مساوی 4 میلی ­متر (0/73 در مقابل 100 درصد و 018/0=p) و سابقه خانوادگی بدخیمی رحم (2/35 در مقابل 8/83 درصد و 026/0=p)، کم­تر بود. شایع ­ترین نوع پاتولوژی در هر دو گروه، اندومتروئید آدنوکارسینوم گرید 1 بود که این تفاوت، معنی­ دار نبود (780/0=p).
نتیجه ­گیری: بین سطح استرادیول با ضخامت بالای آندومتر و سابقه خانوادگی بدخیمی رحم در زنان با بدخیمی آندومتر ارتباط وجود دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The relationship of estradiol level with clinical characteristics of postmenopausal women with endometrial malignancies and abnormal uterine bleeding

نویسندگان [English]

  • Tahereh Ashraf Ganjouei 1
  • Hadis Nasiri Shahandashti 2
1 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Considering the relatively high importance and complications of endometrial malignancies, especially during menopause, and considering that the role of endocrine hormones was not fully clarified, this study was performed with aim to determine the relationship between estradiol levels and the clinical characteristics of postmenopausal women with bleeding and endometrial malignancy.
Methods: This analytical cross-sectional study was conducted in 2023 on 54 patients with postmenopausal bleeding suffering from endometrial malignancy who referred to Imam Hossein (AS) hospital. Demographic and clinical (signs and symptoms) characteristics and serum estradiol levels of patients were collected. Data were analyzed by SPSS software (version 23) and Man-Whitney and Chi-square tests. P<0.05 was considered significant.
Results: Serum estradiol level was 26.80±15.77 pg/ml. In addition, 37 people (68.5%) had normal levels and 17 (31.5%) had abnormal levels of estradiol. In the normal estradiol group compared to abnormal estradiol, the prevalence of endometrial thickness ≥ 4 mm (0.73% vs. 100% and p=0.018) and family history of uterine malignancy (35.2% vs. 83.8% and p=0.026) was less. The most common type of pathology in both groups was grade 1 endometrioid adenocarcinoma, and this difference was not significant (p=0.780).
Conclusion: There is a correlation between estradiol level with high endometrial thickness and family history of uterine malignancy in women with endometrial malignancy.

کلیدواژه‌ها [English]

  • Abnormal uterine bleeding
  • Endometrial malignancy
  • Estradiol
  • Menopause

مراجع

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 4
تیر 1403
صفحه 9-17

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