بررسی تأثیر کپسول خوراکی پروبیوتیک بر افسردگی پس از زایمان زنان نخست‌زا: کارآزمایی شاهددار تصادفی سه‌سوکور

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 استادیار گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 دانشیار گروه علوم دارویی در طب ایرانی، دانشکده طب ایرانی و مکمل، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 دانشیار گروه آمار زیستی، دانشکده بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: دوران پس از زایمان، بحرانی‌ترین ایام برای بروز مشکلات روحی و افسردگی می‌باشد. به‌نظر می‌رسد، پروبیوتیک‌ها با تغییر فلور میکروبی روده بر سلامت روانی تأثیرگذار هستند؛ از‌این‌رو، مطالعه حاضر با هدف تعیین تأثیرگذاری کپسول خوراکی پروبیوتیک بر افسردگی پس از زایمان زنان نخست‌زا انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی سه‌سوکور در سال 1402 بر روی 60 زن نخست‌زای تازه زایمان کرده واجد شرایط در مشهد انجام شد. افراد در دو گروه 30 نفره دارو و دارونما قرار گرفتند. گروه دارو از روز سوم پس از زایمان روزانه یک عدد کپسول پروبیوتیک و گروه دارونما کپسول پلاسبو به‌مدت 30 روز دریافت کردند. پرسشنامه افسردگی پس از زایمان ادینبورگ قبل و بعد از مداخله توسط دو گروه تکمیل شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 25) و آزمون‌های تی‌تست، من‌ویتنی و ویلکاکسون انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته ­ها: دو گروه از نظر مشخصات دموگرافیک و مامایی همگن بودند. میانگین نمره افسردگی قبل از مداخله در دو گروه دارو و دارونما اختلاف آماری معناداری نداشت (809/0=p). بعد از مداخله میانگین نمره افسردگی در گروه دارونما 33/4± 56/4 و در گروه دارو 40/0±00/1 بود که اختلاف آماری معناداری داشت (0001/0=p).
نتیجه ­گیری: مصرف کپسول­ های پروبیوتیک می‌تواند افسردگی زنان را در دوران پس از زایمان کاهش ‌دهد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Oral Probiotic Capsules on Postpartum Depression in Primiparous Women: A Triple-blind Randomized Control trial

نویسندگان [English]

  • maryam rastegar 1
  • Nahid Jahani Shoorab 2
  • Roshanak Salari 3
  • Azadeh Saki 4
1 M.Sc. Student of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant professor, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Associate professor, Department of Pharmaceutical Sciences in Iranian Medicine, School of Iranian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate Professor, Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: The postpartum period is the most critical period for presenting mental problems and depression. It seems that probiotics can affect mental health by changing the intestinal microbial flora; therefore, the present study was conducted with aim to determine the effectiveness of oral probiotic capsule on postpartum depression of primiparous women.
Methods: This triple-blind randomized clinical trial study was conducted in 2023 on 60 qualified primiparous women who had just given birth in Mashhad. The women were placed in two groups of 30 people, drug and placebo. The drug group received one probiotic capsule daily from the third day after delivery, and the placebo group received a placebo capsule for 30 days. Edinburgh postpartum questionnaire was completed by the two groups before and after the intervention. Data were analyzed using SPSS statistical software (version 25) and t-test, Mann-Whitney and Wilcoxon tests. P<0.05 was considered statistically significant.
Results: The two groups were homogeneous in terms of demographic and obstetric characteristics. There was no statistically significant difference between the drug and placebo groups in the mean score of depression before the intervention (p=0.809). After the intervention, the mean score of depression in the placebo group was 4.56±4.33 and in the drug group was 1.00±0.40, which had a statistically significant difference (p=0.0001).
Conclusion: Consuming probiotic capsules can reduce women's depression in the postpartum period.

کلیدواژه‌ها [English]

  • Depression
  • Maternal health
  • Postpartum
  • Primiparous Mothers
  • Probiotics

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مجله زنان، مامایی و نازایی ایران
دوره 27، شماره 3
خرداد 1403
صفحه 64-75

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