بررسی رابطه سن ابتلاء به بیماری با پیش‌آگهی سرطان پستان در زنان

نوع مقاله : اصیل پژوهشی

نویسندگان

1 استادیار گروه جراحی پلاستیک، مرکز تحقیقات بیماری‌های غیرواگیر، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

2 پزشک عمومی، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

3 مربی گروه بیهوشی، مرکز تحقیقات مؤلفه‌های اجتماعی نظام سلامت، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

4 فلوشیپ بیماری سینه، مرکز تحقیقات بیماری‌های غیرواگیر، دانشکده پزشکی، دانشگاه علوم پزشکی جهرم، جهرم، ایران.

چکیده

مقدمه: سرطان پستان، شایع‌ترین نوع سرطان و دومین عامل مرگ ناشی از سرطان در زنان به‌شمار می‌رود. شدت و اهمیت عوامل خطر و رفتارهای مستعد کننده در هر منطقه متفاوت است. وجود تحلیل ارتباط بین عوامل پیش‌آگهی در زنان مبتلا به سرطان پستان می­ تواند فرآیند درمان بیماران را تحت تأثیر قرار دهد. مطالعه حاضر با هدف بررسی رابطه سن ابتلاء به بیماری با پیش ­آگهی سرطان پستان در زنان انجام شد.
روش‌کار: این مطالعه مقطعی- توصیفی بر روی 160 نفر از بیمارانی که در سال 98-1396 به مرکز جامع سرطان خاتم‌الانبیاء مراجعه کرده و تشخیص سرطان پستان آنها بر اساس گزارش پاتولوژی تعیین گردید، انجام گرفت. اطلاعات موجود در چک‌‌لیست با استفاده از پرونده بیماران مورد بررسی قرار گرفت. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار SPSS (نسخه 21) و آزمون ضریب همبستگی اسپیرمن و تحلیل بقاء و منحنی کاپلان مایر (طول عمر) انجام گرفت. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته­ ها: بین سن ابتلاء با stage سرطان پستان (891/0=p، 018/0=r) و اندازه ضایعات در زمان تشخیص سرطان پستان (031/0=r، 721/0=p) ارتباط آماری معنی‌داری وجود نداشت. بر اساس نتایج ضریب همبستگی اسپیرمن، بین سن ابتلاء با درگیری گره‌های لنفاوی (190/0-=r، 016/0=p) و فاکتور پیش‌آگهی Her2 در زمان تشخیص سرطان پستان (167/0-= r، 045/0=p) ارتباط آماری معنی‌داری وجود داشت و با افزایش سن ابتلاء، درگیری گره‌های لنفاوی و Her2 در زمان تشخیص سرطان پستان کاهش می‌یافت.
نتیجه ­گیری: بیشترین فراوانی سن زنان شرکت‌کننده در مطالعه در محدوده 50-41 سال بود، اما بر اساس تحلیل بقاء بر اساس گروه سنی، بقاء در افراد بالای 70 سال بیشتر از سایر گروه‌های سنی (54/0±71/4 سال) بود؛ با این حال نمودار کاپلان میر در مطالعه حاضر تفاوتی بین رده­ های سنی مختلف نشان نداد، اما با افزایش سن ابتلاء، Her2 و درگیری گره‌های لنفاوی در زمان تشخیص سرطان پستان کاهش می‌یافت.

کلیدواژه‌ها

عنوان مقاله [English]

The relationship between age of disease onset and prognosis of breast cancer in women

نویسندگان [English]

  • Mojtaba Ghaedi 1
  • Fatemeh Feiz 2
  • Navid Kalani 3
  • Naser Hatami 2
  • Marzieh Haghbeen 4
1 Assistant professor, Department of Plastic Surgery, Research Center for Noncommunicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
2 General practitioner, Student Research Committee, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3 Instructor, Department of Anesthesiology, Research Center for Social Determinants of Health, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4 Fellowship of Breast Diseases, Research Center for Noncommunicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
چکیده [English]

Introduction: Breast cancer is the most common type of cancer and the second leading cause of cancer death in women. The severity and importance of risk factors and predisposing behaviors are different in each region. Analysis of the relationship between prognostic factors in women with breast cancer can affect the treatment process of patients. The present study was performed with aim to investigate the relationship between age of disease onset and the prognosis of breast cancer in women.
Methods: This cross-sectional descriptive study was performed on 160 patients referred to Khatam Al-Anbia Cancer Clinic in Jahrom in 2021 and their cancer was confirmed based on pathology report. The information in the questionnaire was analyzed using patients' files. Data were analyzed by SPSS software (version 21) and Spearman's correlation coefficient test and survival analysis and Kaplan-Meier curve (survival). P<0.05 was considered statistically significant.
Results: There was no statistically significant relationship between age of disease onset and stage of breast cancer (r = 0.018, P = 0.891) and the size of lesions at the time of breast cancer diagnosis (r = 0.031, P = 0.721). Spearman correlation coefficient showed that there was a statistically significant relationship between the age of disease onset and lymph node involvement (r = -0.190, P = 0.016) and the prognostic factor Her2 at the time of breast cancer diagnosis (r = -0.167, P = 0.045); as the age of onset increases, Her2 decreases at the time of breast cancer diagnosis.
Conclusion: The highest frequency of age of women participating in the study was in the range of 41 to 50 years, but according to survival analysis based on age group, survival was higher in people over 70 years than other age groups (4.71±0.54 years). However, the Kaplan Mir chart did not show a difference between the different age groups, but as age increases, Her2 and lymph node involvement decreases at the time of breast cancer diagnosis.

کلیدواژه‌ها [English]

  • Age of onset
  • Breast cancer
  • Lymph nodes
  • Prognosis

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مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 12
اسفند 1401
صفحه 22-32

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