گیاهان دارویی مؤثر بر خونریزی های زنان و مامایی: مرور سیستماتیک بر کارآزمایی های بالینی انجام شده

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد مامایی، گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران.

2 دکتری بهداشت باروری، گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران.

3 کارشناس ارشد مامایی، مرکز تحقیقات علوم بهداشتی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران.

چکیده

مقدمه: هر زنی در طول زندگی خود ممکن است با خونریزی‌های تهدید‌کننده حیات مانند خونریزی‌های طی بارداری، زایمان و پس از آن و یا خونریزی‌هایی که کمتر تهدید‌کننده حیات بوده، اما زندگی زن را تحت‌الشعاع قرار می‌دهد مانند خونریزی‌های غیر‌طبیعی رحمی مواجه گردد. با توجه به اهمیت پیشگیری و مهار خونریزی‌های مامایی و لزوم یافتن روش درمانی مؤثر و کم‌عارضه، مطالعه حاضر با هدف ارزیابی و جمع‌بندی نتایج کارآزمایی‌های بالینی انجام‌ شده در مورد تأثیر گیاهان دارویی مؤثر بر خونریزی‌های مامایی انجام شد.
روش‌کار: در این مطالعه مروری تمامی مطالعات مرتبط (بر اساس PRISMA) از پایگاه‌های اطلاعاتی مرکز ثبت کارآزمایی‌های بالینی Google scholar، Scopus، IranMedex، SID، Medlib، Magiran و PubMed با کلیدواژه‌های بارهنگ کبیر، بارهنگ نیزه‌ای، گلنار، زنجبیل، بابونه، بومادران، هسته انگور، زیره، شوید، رازیانه، ویتاگنوس، خونریزی پس از زایمان، خونریزی قاعدگی، خونریزی، منوراژی، کارآزمایی بالینی، طب سنتی و معادل انگلیسی آنها بدون محدودیت زمانی تا نوامبر 2021 جستجو شدند. تجزیه و تحلیل مطالب به‌صورت کیفی صورت گرفت.
یافته‌ها: در این مطالعه، 148 مقاله استخراج شد. سپس 28 کارآزمایی بالینی که بر اساس جداد نمره 3 یا بیشتر گرفتند و معیار‌های مطالعه را داشتند، وارد مطالعه شدند. مقالات مربوط به 10 نوع از گیاهان دارویی با حجم نمونه 2666 نفر مورد بررسی قرار گرفتند که نتایج این مطالعات نشان می‌دهد گیاهان مورد بررسی در کاهش خونریزی‌های زنان و مامایی مؤثر بوده‌اند.
نتیجه‌گیری: از گیاهان دارویی مورد بررسی در این مطالعه می‌توان برای پیشگیری و کنترل خونریزی در زنان استفاده کرد. با این حال، قضاوت در مورد تأثیر قطعی این مداخلات قطعاً مستلزم مطالعات گسترده‌تری است. 

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Medicinal Plants on Gynecological and Obstetric Hemorrhages: A Systematic Review of Clinical Trials

نویسندگان [English]

  • Seyedeh Adeleh Rahmanian 1
  • Morvarid Irani 2
  • Maryam Aradmehr 3
1 M.Sc. in Midwifery, Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
2 PhD in Reproductive Health, Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
3 M.Sc. in Midwifery, Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
چکیده [English]

Introduction: Every woman during her life may experience life-threatening bleeding such as bleeding during pregnancy, childbirth and after delivery, or bleeding which is less life-threatening but overshadows the woman's life, such as abnormal uterine bleeding (AUB). Regarding to the importance of preventing and controlling the obstetrics bleeding and the need to find an effective and low-complication treatment method, this systematic review was conducted with aim to determine the effect of herbal medicines on gynecological and obstetric hemorrhages.
Methods: In this systematic review study, all the related studies (based on PRISMA) were searched in databases of clinical randomized registration center and PubMed, Magiran, Medlib, SID, IranMedex, Scopus, and Google scholar using the key words of ( Plantago major, plantain, Plantago (lanceolate), Punica granatum, Persian gulnar, Ginger, Zingiber officinale, Chamomile, Achillea millefolium, Grape Seed, cumin (cuminum), Anethum graveolens (dill), Foeniculum (Fennel), Vitex (Chasteberry), postpartum hemorrhage, Menstrual bleeding, bleeding, menorrhagia, randomized clinical trial, and traditional medicine without time limitation until Nov 2021. Data were analyzed qualitatively.
Results In this study, 148 articles were extracted. Also, 28 clinical trials which received Jedad score ≥ 3 and met the inclusion criteria entered the study. The articles related to 10 types of medicinal plants with a sample size of 2666 people were studied. According to the results, the studied plants were effective in reducing gynecological and obstetric hemorrhages.
Conclusion: The medicinal plants studied in this study can be used for preventing and controlling bleeding in women. However, judging the definite effect of these interventions definitely requires more extensive studies.
 

کلیدواژه‌ها [English]

  • Bleeding
  • Clinical trial
  • Medicinal Plants
  • Menorrhagia
  • Menstruation
  • Postpartum Hemorrhage

مراجع

  1. Ministry of Health and Medical Education, Department of Maternal Health. National Guide to Midwifery and Maternity Services. Available at: http://www.bahmanhospital.ir/learning-doctor/43.pdf
  2. Fakour F, Mirzayi M, Naghipour MR, Ebrahimi H, Mahdavi M. Comparison between sublingual misoprostol and intravenous oxytocin in management of third stage of labor. Iran J Obstet Gynecol Infertil 2012; 15(34):7-14.
  3. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics. 25nd New York: McGraw-Hill Education; 2018.
  4. Zendedel A, Jahanmardi F, Anbari K, Gorji M. Frequency of iron deficiency anemia and its related factors in adult patients referred to the internal clinic of Shohada Ashayer from 6 March to 6 July 2011. yafte 2012; 14(1):31-37.
  5. Sheldon W, Blum J, Vogel JP, Souza JP, Gülmezoglu AM, Winikoff B, et al. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG: An International Journal of Obstetrics & Gynaecology 2014; 121:5-13.
  6. Mojahed SH, Aflatunian A, Khadem N, Dehghani Firouzabadi R, Karimi Zarchi M. An investigation into effectiveness of date (Rutab) on postpartum hemorrhage. SSU_Journals 2012; 20(2):159-66.
  7. Izzo AA, Hoon‐Kim S, Radhakrishnan R, Williamson EM. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytotherapy research 2016; 30(5):691-700.
  8. Khojastehfard Z, Yazdimoghaddam H, Abdollahi M, Karimi FZ. Effect of herbal medicines on postpartum hemorrhage: A systematic review and meta-analysis. Evidence Based Care Journal 2021; 11(1):62-74.
  9. Kim HS. Do not put too much value on conventional medicines. Journal of ethnopharmacology 2005; 100(1-2):37-9.
  10. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled clinical trials 1996; 17(1):1-12.
  11. Khojastehfard Z, Golmakani N, Mazloum SR, Hamedi SS, Feyzabadi Z, Mirteimouri M. The effect of plantago major rectal suppository on postpartum hemorrhage rate in women at the risk of bleeding: a single-blind clinical trial. Iran J Obstet Gynecol Infertil 2019; 22(7):58-65.
  12. Nejati N, Dolatian M, Kamalinejad M, Khabazkhoob M. The effect of Plantago oral syrup on hemoglobin and hematocrit levels in women with normal postpartum hemorrhage. Iran J Obstet Gynecol Infertil 2018; 21(4):72-8.
  13. Khodabakhsh M, Mahmoudinia M, Mousavi Bazaz M, Hamedi SS, Hoseini SS, Feyzabadi Z, et al. The effect of plantain syrup on heavy menstrual bleeding: A randomized triple blind clinical trial. Phytotherapy Research 2020; 34(1):118-25.
  14. Navaei F, Ebrahimzadeh MA, Formi EN, Jamkhaneh AE, Saeedi M, Amiri FB, et al. The Effect of plantago major VAGINAL SUPP on Heavy Menstrual Bleeding Patients with Uterine Leiomyoma: A Double-blind Randomized Clinical Trial. P J M H S 2020; 14(3):1678-85.
  15. Goshtasebi A, Mazari Z, Gandevani SB, Naseri M. Anti-hemorrhagic activity of Punica granatum L. flower (Persian Golnar) against heavy menstrual bleeding of endometrial origin: a double-blind, randomized controlled trial. Medical journal of the Islamic Republic of Iran 2015; 29:199.
  16. Yousefi F, Kashanian M, Nazem I, Bioos S, Sadeghpour O, Aliasl J, et al. Comparison between Golnar product and placebo in heavy menstrual bleeding: A double-blind randomized clinical trial. Avicenna Journal of Phytomedicine 2020; 10(5):523-32.
  17. Memarzadeh H, Eftekhar T, Tansaz M, Hashem F, Dabaghian MK, Foroughifar T, et al. Evaluation of efficacy of Punica granatum L.(Persian gulnar) on uterine leiomyoma related menorrhagia. International Journal of Biosciences 2015; 6:18-25.
  18. Khademi N, Matouripour P, Vakilian K. Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia. Iran J Obstet Gynecol Infertil 2019; 22(2):34-41.
  19. Ebrahimi Varzaneh F, Nahidi F, Mojab F, Pourhoseingholi MA. Effect of Achillea millefolium on the intensity and duration of menstrual bleeding of women with menorrhagia. Iran J Obstet Gynecol Infertil 2020; 23(2):67-77.
  20. Eshaghian R, Mazaheri M, Ghanadian M, Rouholamin S, Feizi A, Babaeian M. The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: A randomized, placebo-controlled, clinical trial. Complementary therapies in medicine 2019; 42:42-7.
  21. Kashefi F, Khajehei M, Alavinia M, Golmakani E, Asili J. Effect of Ginger (Zingiber officinale) on heavy menstrual bleeding: A placebo‐controlled, randomized clinical trial. Phytotherapy research 2015; 29(1):114-9.
  22. Ehsani P, Nazayer H, Memari A. The efficiency of herbal medicine (Anthemis, Salvia, and Zataria) on menstrual cycle blood discharging. Woman and Culture 2014; 5(18):127-140.
  23. Shabani F, Vakilian K, Narenji F, Bozorgi M, Bioos S, Nejatbakhsh F. Comparison of the effect of Chamomile and Mefenamic Acid on primary dysmenorrhea, associated symptoms and menstrual bleeding–A randomized clinical trial study; 2018.
  24. Karimian Z, Sadat Z, Abedzadeh M, Sarafraz N, Kafaei Atrian M, Bahrami N. Comparison the effect of mefenamic acid and Matricaria Chamomilla on primary dysmenorrhea in Kashan medical university students. Journal of Ardabil University of Medical Sciences 2013; 13(4):413-20.
  25. Abedian Z, Rezvani Fard M, Asili J, Esmaeili H, Dadgar S. Comparison of the Effect of chamomile matricaria and mefenamic acid capsules on postpartum hemorrhage in women with postpartum pain. Iran J Obstet Gynecol Infertil 2016; 19(14):1-8.
  26. Izadpanah A, Alahyari E, Torshizi M, Khazaie Z, Sharifzadeh G, Hosseini M. Effect of grape seed powder on postpartum hemorrhage in vaginal delivery: a randomized controlled clinical trial. Iran J Obstet Gynecol Infertil 2018; 21(10):30-7.
  27. Fazel N, Esmaeili H. The effect of cumin oil on post partum hemorrhage after cesarean section. Teb va Tazkieh 2008; (68-69):78-81.
  28. Rajabi NM, Modarres M, Amin GH, Bahrani N. A comparative study of the effects of cumin and mefenamic acid capsules on menstrual bleeding in IUD users: a randomized triple blind clinical trial. Journal of Medicinal Plants 2015; 14(54):159-68.
  29. Mandavian M, Golmakani N, Mansoori A, Hossemzade H, Afzalaghaee M. An investigation of effectiveness of oral dill extracts on postpartum hemorrhage. Iran J Obstet Gynecol Infertil 2002; 4(7-8):19-26.
  30. Khojastehfard Z, Salarfard M, Hamedi SS, Feyzabadi Z, Golmakani N. The effect of rectal suppository of anethum graveolens on the postpartum hemorrhage rate: Evidence from a single-blind clinical trial study. Jundishapur Journal of Natural Pharmaceutical Products 2021; 16(2).
  31. Akhavan Amjadi M, Zahrani S, Mojab F, Alavi Majd H. Efficacy of Foeniculum vulgare Mill extract on menstrual bleeding over the students of Shahid Beheshti University in Tehran 2005. Journal of Medicinal Plants 2010; 9(34):117-23.
  32. Bokaie M, Enjezab B. The effects of oral fennel extract on the intensity of menstrual bleeding in relieving dysmenorrheal: a randomized clinical trial. Community Health Journal 2017; 8(1):55-62.
  33. Ghodsi Z, Asltoghiri M. The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea. Journal of pediatric and adolescent gynecology 2014; 27(5):283-6.
  34. Shobeiri F, Zeraati F, Araghchian M, Nazari M. The effect of fennelin, vitagnus and mefenamic acid in the treatment of menstrual bleeding. Avicenna Journal of Clinical Medicine 2014; 21(3):171-6.
  35. Zamani M, Mansour GM, Farimani M, Nasr ES. Efficacy of mefenamic acid and vitex in reduction of menstrual blood loss and HB changes in patients with a complaint of menorrhagia. Iran J Obstet Gynecol Infertil 2007; 10(1):79-86.
  36. Mirghafourvand M, Mohammad Alizadeh charandabi S, javadzadeh Y, Ahmadpour P. The Effect of Vitex agnus and Flaxseed on the Menstrual Bleeding: a Randomized Controlled Trial. J Adv Med Biomed Res 2015; 23(100):1-12
  37. Yavarikia P, Shahnazi M, Hadavand Mirzaie S, Javadzadeh Y, Lutfi R. Comparing the effect of mefenamic Acid and vitex agnus on intrauterine device induced bleeding. J Caring Sci 2013; 2(3):245-54.
  38. Oreščanin V, Findri Guštek Š. The Treatment of Menorrhagia with Bioapigyn® Herbal Ointment and Pessaries. Agriculturae Conspectus Scientificus 2019; 84(1):123-5.
  39. Mazinani J, Vatandoost J, Vaezi Kakhki MR, Ghorat F. Evaluation of the in vitro effect of ethanolic extract of broadleaf plantain (Plantago major L.) seeds on the blood coagulation process. Iranian Journal of Medicinal and Aromatic Plants Research 2020; 36(4):552-9.
  40. Chi Mbatchou V, James Williams T. Investigation of Hemostasis Using Plantain Sheath/Stem, Cassava Leaf and Snail Juices in Human Blood in-vitro. Med Aromat Plants (Los Angeles) 2020; 9(362):2167-0412.
  41. Tansaz M, Memarzadehzavareh H, Qaraaty M, Eftekhar T, Tabarrai M, Kamalinejad M. Menorrhagia management in Iranian traditional medicine. Journal of evidence-based complementary & alternative medicine 2016; 21(1):71-6.
  42. Kazhal H, Katayoon H, Mohsen Z. A review of Plantago plant. Indian Journal of Traditional Knowledge 2014; 13:681-5.
  43. Memarzadeh Zavvareh H, Tansaz M, Heidarirad GH, GHaraati M and Nikkhajuii M. Effect of Persian Golnar Product on uterine volume and menorrhagia in People With uterine leiomyoma: a case report. First International Congress of Complementary and Alternative Medicine 2015: 7-9.
  44. Applequist WL, Moerman DE. Yarrow (Achillea millefolium L.): a neglected panacea? a review of ethnobotany, bioactivity, and biomedical research1. Economic Botany 2011; 65(2):209-25.
  45. Mozafari S, Saei Ghare Naz M, Ozgoli G. Effect of Ginger on primary Dysmenorrhea: A systematic review of clinical trials and Quasi-Experimental studies in the world. Iran J Obstet Gynecol Infertil 2018; 21(Supple):86-93.
  46. Shirooye P, Adhami S, Hamzeloo-Moghadam M, Hashem Dabaghian F, Mokaberinejad R. Comparison of oral and topical effect of ginger on the rate of menstrual bleeding. Iran J Obstet Gynecol Infertil 2021; 24(9):24-31.
  47. Azhari S, Aradmehr M, Rakhshandeh H, Tara F, Shakeri M. The Effects of Chamomile Cream on Wound Healing of Episiotomy in Primiparous Women. The Iranian Journal of Obstetrics, Gynecology and Infertility, 2014; 17(93): 16-26. doi: 10.22038/ijogi.2014.2747
  48. Rabiei Z, Rafieian M. A review on the pharmacological effects of Matricaria chamomilla. Iranian Journal of Physiology and Pharmacology 2018; 2(4):240-8.
  49. Khorshidi N, Ostad SN, Mosaddegh M, Soodi M. Clinical effects of fennel essential oil on primary dysmenorrhea. Iranian journal of pharmaceutical research 2010; 20(2):89-93.
مجله زنان، مامایی و نازایی ایران
دوره 25، شماره 7
مهر 1401
صفحه 113-127

فایل ها

هم رسانی

ارجاع به این مقاله

آمار