مقایسه تأثیر کپسول خوراکی گل‌مغربی و روغن کرچک بر نمره بیشاپ و برخی پیامدهای زایمانی (کارآزمایی بالینی سه‌سوکور)

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

2 مربی گروه مامایی، دانشکده پرستاری و مامایی، مرکز تحقیقات مراقبت سالمندی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

3 دانشیارگروه بهداشت باروری، دانشکده پرستاری و مامایی، مرکز تحقیقات مراقبت سالمندی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

4 استاد گروه اپیدمیولوژی و آمار زیستی، دانشکده پزشکی، مرکز تحقیقات محیط کار، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

10.22038/ijogi.2022.20099

چکیده

مقدمه: در چندین مطالعه تأثیر گل‌مغربی و روغن کرچک بر نمره بیشاپ و پیامدهای زایمانی بررسی شده، ولی مقایسه آنها مورد سؤال است. مطالعه حاضر با هدف مقایسه­ تأثیر گل‌مغربی و روغن کرچک همزمان با القاء لیبر بر نمره بیشاپ و برخی پیامدهای زایمانی در زنان باردار انجام شد.
روش ­کار: این مطالعه کارآزمایی بالینی تصادفی شده­ سه‌سوکور در سال 1398 بر روی 114 زن باردار مراجعه‌کننده به زایشگاه نیک‌نفس رفسنجان انجام شد. افراد به دو گروه مداخله تخصیص یافتند. گروه مداخله اول دو عدد کپسول­ 1000 میلی­گرمی گل مغربی خوراکی و گروه دوم 6 عدد کپسول روغن کرچک خوراکی همزمان با القاء لیبر دریافت کردند. اطلاعات نمره بیشاپ و پیامدهای زایمانی با استفاده از پرونده بیمارستانی جمع‌آوری و با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون­های تحلیل واریانس در اندازه‌گیری­های مکرر، کای اسکوئر و تی مستقل مورد تجزیه و تحلیل قرار گرفتند. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته­ ها: میانگین و انحراف معیار نمره بیشاپ 2 ساعت بعد از القاء در گروه‌ گل‌مغربی و روغن کرچک به‌‌ترتیب 69/1±36/5 و 42/1±02/5 (542/0=p) و 4 ساعت بعد از القاء 58/1±63/7 و 94/1±32/7 (492/0=p) بود که اختلاف آماری معنی‌داری نداشتند. مقایسه اختلاف میانگین‌ داخل‌ هر‌کدام از گروه‌های کپسول گل مغربی و روغن کرچک معنی­دار بود (001/0>p). دو گروه از نظر نمره بیشاپ، نوع زایمان، نمره آپگار، دقیقه اول و پنجم، طول مرحله اول و دوم لیبر اختلاف آماری معنی­داری نداشتند (05/0<p).
نتیجه­ گیری: گل‌مغربی و روغن کرچک در مقایسه با هم بر آمادگی سرویکس و پیامدهای بارداری همزمان با القاء لیبر اختلاف آماری معنی‌دار نداشتند، لذا کاربرد یکی بر دیگری برتری ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of evening primrose and castor oil capsule on Bishop Score and some delivery outcomes (triple-blind clinical trial)

نویسندگان [English]

  • Mahdiyeh Sadat Hoseinipour 1
  • Zahra Saghafi 2
  • Marziyeh Loripour 3
  • Mohsen Rezaeian 4
1 M.Sc. student in Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2 Instructor, Department of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3 Associate professor, Department of Reproductive Health, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4 Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, Occupation Environment Research Center , Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
چکیده [English]

Introduction: In several studies, the effect of evening primrose and castor oil on bishop score and delivery outcomes have been investigated, but comparing their effects is questionable. This study was performed with aim to compare the effect of oral castor oil and evening primrose at the same time with induction of labor on Bishop score and some delivery outcomes in pregnant women.
Methods: This triple-blind randomized clinical trial study was performed in 2019 on 114 pregnant women referring to Niknafs maternity hospital of Rafsanjan. The subjects were randomly divided into two intervention group. The first intervention group received two capsules of 1000 mg of evening primrose and the second received 6 capsules of castor oil concurrently with labor induction. Bishop's score information and delivery outcomes were collected using the hospital records. Data were analyzed by SPSS software (version 16) and analysis of variance in repeated measures, Chi-square, and independent t-tests. P<0.05 was considered statistically significant.
Results: The mean and standard deviation of evening primrose and castor oil in each group were effective on the bishop score two hours after induction (5.02 ± 1.42, 5.36 ± 1.69, respectively) (P=0.542) and four hours after induction (7.32 ± 1.94, 7.63 ± 1.58, respectively) (P=0.492) and the difference was statistically significant. Comparison of mean differences within each group of evening primrose capsules and castor oil was significant (P<0.001). There was no statistically significant difference between the two groups in terms of bishop score, type of delivery, Apgar score, first and fifth minutes, length of first and second stage of labor (P>0.05).
Conclusion: There was no statistically significant difference between evening primrose and castor oil on cervical ripening and pregnancy outcomes at the same time as labor induction, therefore, the use of one is not superior to the other.

کلیدواژه‌ها [English]

  • Bishop Score
  • Caster oil
  • Cervical Ripening
  • Evening Primrose Oil
  • Labor induction
  1. Razali N, Mohd Nahwari SH, Sulaiman S, Hassan J. Date fruit consumption at term: Effect on length of gestation, labour and delivery. Journal of Obstetrics and Gynaecology 2017; 37(5):595-600.
  2. Ghasemi V, Rashidi Fakari F, Ebadi A, Ozgoli G, Kariman N, Saei Gharenaz M. Effective interventions for the induction of labor: A systematic review. Iran J Obstet Gynecol Infertil 2018; 21(1):90-104.
  3. Kordi M, Aghaei Meybodi F, Tara F, Nematy M, Shakeri MT. The effect of date consumption in late pregnancy on the onset of labor in nulliparous women. Iran J Obstet Gynecol Infertil 2013; 16(77):9-15.
  4. Caughey AB, Cahill AG, Guise JM, Rouse DJ, American College of Obstetricians and Gynecologists. Safe prevention of the primary cesarean delivery. American journal of obstetrics and gynecology 2014; 210(3):179-93.
  5. Navve D, Orenstein N, Ribak R, Daykan Y, Shechter-Maor G, Biron-Shental T. Is the Bishop-score significant in predicting the success of labor induction in multiparous women?. Journal of Perinatology 2017; 37(5):480-3.
  6. Heydari A, Nasiri F, Kariman N. Effect of topical magnesium sulfate in latent phase on Bishop Score and latent phase duration in primiparous women. Iran J Obstet Gynecol Infertil 2020; 23(2):42-9.
  7. Naghizadeh S, Kazemi AF, Hemmatzadeh S, Ebrahimpour M. The relationship between the Bishops score at admission and deliver outcomes in nulliparous women in 29 Bahman hospital, Tabriz. Iran J Obstet Gynecol Infertil 2016; 19(6):11-21.
  8. Van der Voet LF, Bij de Vaate AM, Veersema S, Brölmann HA, Huirne JA. Long‐term complications of caesarean section. The niche in the scar: a prospective cohort study on niche prevalence and its relation to abnormal uterine bleeding. BJOG: An International Journal of Obstetrics & Gynaecology 2014; 121(2):236-44.
  9. Shahoei R, Zaheri F, Hashemi Nasab L, Roshani D, Hesami K. Relationship between induction success and Bishop Score in pregnant women who referred to Besat hospital in Sanandaj, 2013. Iran J Obstet Gynecol Infertil 2016; 19(18):1-8.
  10. Dastjerd F, Erfanian F, Sazegarnia A, Akhlaghi F, Kordi M, Esmaeili H. Effect of infrared belt and hot water bag on the duration of first stage of labor in Primiparous women: A Randomized Clinical Trial. Iran J Obstet Gynecol Infertil 2021; 23(10):82-95
  11. Stock SJ, Ferguson E, Duffy A, Ford I, Chalmers J, Norman JE. Outcomes of elective induction of labour compared with expectant management: population based study. Bmj 2012; 344.
  12. Rahimi G, Pourfarzi F, Fouladi N, Chamheidar N, Shahbazzadegan S. Comparison of the Effect of Vaginal Isosorbide Mononitrate and Estradiol on Cervical Ripening in Term Pregnancy: A controlled clinical trial. Iran J Obstet Gynecol Infertil 2018; 21(7):1-9.
  13. Kelly AJ, Malik S, Smith L, Kavanagh J, Thomas J. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term.-Cochrane database of systematic reviews (Online)-N° 4; 2017.
  14. Austin K, Chambers GM, de Abreu Lourenco R, Madan A, Susic D, Henry A. Cost‐effectiveness of term induction of labour using inpatient prostaglandin gel versus outpatient Foley catheter. Australian and New Zealand Journal of Obstetrics and Gynaecology 2015; 55(5):440-5.
  15. Aquino PA, Fernandez HD, Garcia MI, Barrientos MA, Apepe ET, Pichay RL. Determining the ease of cervical dilation in patients given evening primrose oil (Eveprim®) intravaginally before hysteroscopy in postmenopausal and nulliparous, premenopausal women ages 37-77 years old: A pilot study. Journal of Minimally Invasive Gynecology 2011; 18(6):S126-7.
  16. Grobman WA, Caughey AB. Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies. American journal of obstetrics and gynecology 2019; 221(4):304-10.
  17. Gilad R, Hochner H, Savitsky B, Porat S, Hochner-Celnikier D. Castor oil for induction of labor in post-date pregnancies: A randomized controlled trial. Women and Birth 2018; 31(1):e26-31.
  18. Kalati M, Kashanian M, Jahdi F, Naseri M, Haghani H, Sheikhansari N. Evening primrose oil and labour, is it effective? A randomised clinical trial. Journal of Obstetrics and Gynaecology 2018; 38(4):488-92.
  19. Hall HG, McKenna LG, Griffiths DL. Complementary and alternative medicine for induction of labour. Women and Birth 2012; 25(3):142-8.
  20. Azhari S, Pirdadeh S, Lotfalizadeh M, Shakeri MT. Evaluation of the effect of castor oil on initiating labor in term pregnancy. Saudi medical journal 2006; 27(7):1011.
  21. Pirdadeh Beiranvand S, Azhari S, Lotfalizade M, Shakeri MT. The effect of castor oil on initiating labor in 40-42 weeks pregnancy. Journal Of Babol University Of Medical Sciences (Jbums) 2007; 9(4):33-38.
  22. Neri I, Dante G, Pignatti L, Salvioli C, Facchinetti F. Castor oil for induction of labour: a retrospective study. The Journal of Maternal-Fetal & Neonatal Medicine 2018; 31(16):2105-8.
  23. Jamilian M, Heydari M. Comparison of the Efficacy of Castor Oil and Vaginal Misoprostol With Vaginal Misopostol Alone for Treatment of Missed Abortion. Journal of Arak University of Medical Sciences 2015; 18(9):30-8.
  24. Kahnamoyiagdam F, Aghamohammadi M, Rostamnejad M. The effect of castor oil on the induction of labor: a clinical trial. Nursing And Midwifery Journal 2014; 12(5):348-53.
  25. DeMaria AL, Sundstrom B, Moxley GE, Banks K, Bishop A, Rathbun L. Castor oil as a natural alternative to labor induction: A retrospective descriptive study. Women and Birth 2018; 31(2):e99-104.
  26. Jaafarnejad F, Adibmoghaddam E, Emami SA, Saki A. Compare the effect of flaxseed, evening primrose oil and Vitamin E on duration of periodic breast pain. Journal of education and health promotion 2017; 6.
  27. Walfisch A, Mei-Dan E, Hallak M. Trans-cervical double balloon catheter with and without extra-amniotic saline infusion for cervical ripening: a prospective quasi-randomized trial. The Journal of Maternal-Fetal & Neonatal Medicine 2015; 28(7):848-53.
  28. Shahali S, Khatami F, Abbaspoor Z, Gheraghian B. The effect of vaginal evening primrose capsule on cervical ripening in nulliparous women with post-term pregnancy: A clinical trial. Iran J Obstet Gynecol Infertil 2018; 21(8):30-8.
  29. Wormer KC, Bauer A, Williford AE. Bishop Score. StatPearls [Internet]. 2021.
  30. Akbari S, Masoudi M, Anbari K. A comparison of labor outcome with oxytocin and spontaneous delivery in low risk pregnant women. Yafteh 2015; 16(4):44-53.
  31. OS O, Ugwu EO, Dim CC, Ozumba BC, Nkwo PO, Ajah LO, et al. Effectiveness of castor oil in preventing post-term pregnancy in low resource setting: A randomized controlled trial. American Journal of Clinical Medicine Research 2019; 7(2):37-43.
  32. Boel ME, Lee SJ, Rijken MJ, Paw MK, Pimanpanarak M, Tan SO, et al. Castor oil for induction of labour: not harmful, not helpful. Australian and New Zealand Journal of Obstetrics and Gynaecology 2009; 49(5):499-503.
  33. Azarkish F, Absalan N, Roudbari M, Barahooie F, Mirlashari S, Bameri M. Effect of oral castor oil on labor pain in post term pregnancy. Scientific Journal of Kurdistan University of Medical Sciences 2008; 13(3):1-6.
  34. Torres MO. Frequency and Associated Risk Factors of Preterm Birth in a General Hospital in Hidalgo, Mexico. EC Gynaecology 2018; 7:265-70.
  35. Davis L. The use of castor oil to stimulate labor in patients with premature rupture of membranes. Journal of nurse-midwifery 1984; 29(6):366-70.
  36. Jahdi F, Kalati M, Kashanian M, Naseri M, Haghani H. Effect of oral evening primrose capsules on ripening of the cervix in nulliparous iranian pregnant women (a randomized trial). Acta Medica Mediterranea 2016; 32(Specia):1273-9.
  37. Saberi F, Abedzadeh M, Saadat Z. The use of castor oil on cervical ripening in pregnancies. Journal of Mazandaran University of Medical Sciences 2008; 18(63):11-9.
  38. Nonette DN. The effectiveness of evening primrose oil gel capsule as a cervical ripening agent during labor induction as measured by bishop score on term singleton pregnant patients. Philippine Journal of Obstetrics and Gynecology 2017; 41(2):1-4.
  39. DeGolier T, Lyle C, Ortmann A. Aqueous extracts from evening primrose seeds (Oenethera biennis) contract isolated uterine tissues but have no effect on isolated cervical tissues. International Journal of Herbal Medicine 2017; 5(3):10-6.
  40. Ty-Torredes KA. The effect of oral evening primrose oil on bishop score and cervical length among term gravidas. American Journal of Obstetrics & Gynecology 2006; 195(6):S30.
  41. Iravani M, Montazeri S, Afshari P, Souri H. A study on the Safety and Efficacy of Castor Oil for Cervical Ripening and Labour Induction. Jundishapur Scientific Medical Journal Spring 2006; 5(1):398-404.
  42. Najafi M, Loripoor M, Saghafi Z, Kazemi M. The effect of vaginal evening primrose on the Bishop score of term nulliparous women. Nursing Practice Today 2019; 6(4):202-11.