بررسی تأثیر گیاهان دارویی بر آتروفی واژن در زنان یائسه: مطالعه مرور سیستماتیک و متاآنالیز

نوع مقاله : مروری

نویسندگان

1 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران

2 استادیار گروه اتاق عمل، مرکز تحقیقات سلامت سالمندان، دانشکده پیراپزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران

3 استادیار گروه بهداشت عمومی، دانشکده بهداشت، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران. مرکز تحقیقات علوم بهداشتی، دانشگاه علوم پزشکی تربت‌حیدریه، تربت‌حیدریه، ایران

4 استادیار، مرکز تحقیقات مراقبت‌های پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران. گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: آتروفی واژن یکی از مشکلات نسبتاً شایع در سنین یائسگی و از نگرانی­های بهداشتی اصلی در این گروه از زنان می­باشد. مطالعات متعددی در زمینه دارو­های گیاهی در این زمینه انجام شده، ولی یافته­های متفاوتی در مورد کارایی این روش­ها گزارش شده است، مطالعه حاضر با هدف مروری بر مطالعات انجام شده در زمینه تأثیر گیاهان دارویی بر آتروفی واژن در زنان یائسه انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک و متاآنالیز، مقالات چاپ شده در پایگاه­های اطلاعاتی scopus، pubmed، magiran،Cocharane databases ،web of science ، SID و google scholar در بازه زمانی 2020-2000 با استفاده از کلمات کلیدی فارسی آتروفی واژن، درمان آتروفی واژن، کارآزمایی بالینی، گیاهان دارویی، طب مکمل و طب سنتی" و کلیدواژه­های انگلیسی Vaginal Atrophy،vaginal Atrophy treatment، clinical trial، herbal medicine، complementary medicine، traditional medicine مورد بررسی قرار گرفت. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار STATA (نسخه 11) در سطح اطمینان 95% انجام شد. جهت ترکیب مطالعات و انجام متاآنالیز از شاخص نسبت شانس و روش Peto استفاده گردید.
یافته­ها: نتایج حاصل از متاآنالیز نشان داد که در تمامی مطالعات، مداخله گیاهی، منجر به بهبود علائم آتروفی واژن شده بود (001/0>p)؛ به‌طوری‌که شانس بهبود خارش، خشکی و سوزش در گروه مداخله نسبت به گروه کنترل، به‌ترتیب (98/26-82/5 CI؛ 53/12=OR)، (02/11-72/4 CI؛ 21/7=OR) و (55/38-94/8 CI؛ 56/18=OR) بود. همچنین شانس بهبود دیسپارونی، شانس بهبود شاخص بلوغ سلول‌های واژن و شانس کاهش PH واژن در گروه مداخله نسبت به گروه کنترل به‌ترتیب (69/46-79/13 CI؛ 38/25=OR)، (37/43-61/13 CI؛ 30/24=OR) و (59/41-05/13 CI؛ 30/23=OR) بود.
نتیجه‌گیری: بر اساس نتایج متاآنالیز، تأثیر استفاده از گیاهان دارویی بر آتروفی واژن در زنان یائسه از نظر آماری معنی‌دار است و استفاده از روش درمانی گیاهی می­تواند به‌عنوان جانشینی مناسب برای داروهای شیمیایی باشد؛ چراکه در زنان یائسه مورد پذیرش بیشتری نسبت به عوارض هورمون درمانی قرار می­گیرد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of herbal medicines on vaginal atrophy in postmenopausal women: A systematic review and meta-analysis

نویسندگان [English]

  • Mahla Salarfard 1
  • Hamideh Yazdimoghaddam 2
  • Mahbubeh Abdollahi 3
  • Fatemeh Zahra Karimi 4
1 Instructor, Department of Midwifery, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.
2 Assistant Professor, Ph.D of Nursing, Operating Room Department, Faculty of Paramedices, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 Assistant Professor, Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
4 Assistant Professor, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Vaginal atrophy is one of the relatively common problems in menopausal ages and a major health concern in this group of women. Several studies have been done in the field of herbal medicine in this subject, but different findings have been reported on the efficacy of these methods. This study was performed aimed to review the studies on the effect of herbal medicines on vaginal atrophy in postmenopausal women.
Methods: In this systematic review and meta-analysis, published articles in databases of PubMed, Scopus, Magiran, Cochrane, web of science, SID and Google scholar were reviewed between 2000-2020 using English key words of "vaginal Atrophy, vaginal Atrophy treatment, clinical trial, herbal medicine, complementary medicine, traditional medicine”. Data were analyzed using STATA software (version 11) in %95 confidence interval. Odds ratio index and Peto method were used to combine studies and perform meta-analysis.
Results: Meta-analysis results showed that in all studies, herbal intervention improved the symptoms of vaginal atrophy (P<0.001). So that the odds of improving itching, dryness and burning in the intervention group compared to the control group was (OR=12.53, %95 CI: 5.82-26.98), (OR=7.21, %95 CI: 4.72-11.02), and (OR=18.56, %95 CI: 8.94-38.55), respectively. Also, the odds of improving dyspareunia, improving maturity index of vaginal cells and lowering vaginal PH in the intervention group compared to the control group was (OR=25.38, %95 CI: 13.79-46.69), (OR=24.30, %95 CI: 13.61-43.37) and (OR=23.30, %95 CI: 13.05-41.59), respectively.
Conclusion: Based on meta-analysis results, the effect of using herbal medicines on vaginal atrophy in postmenopausal women is statistically significant and the use of herbal remedies can be a good substitute for chemical drugs, because this method is accepted in postmenopausal women more than chemical drugs due to the side effects of hormone therapy.

کلیدواژه‌ها [English]

  • Menopause
  • Meta-analysis
  • Systematic review
  • Vaginal atrophy
  • Women

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 13
اسفند 1400
صفحه 100-118

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