تأثیر کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذر کتان) بر علائم ذهنی آتروفی واژن در زنان یائسه یک کارآزمایی بالینی شاهددار تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 مربی گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استادیار گروه فارماکوگنوزی، مرکز تحقیقات طب سنتی و تاریخ پزشکی، دانشکده داروسازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

4 استادیار گروه آمار زیستی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

5 دانشجوی مهندسی برق، کمیته تحقیقات دانشجویی، دانشکده مهندسی برق و کامپیوتر، دانشگاه سمنان، سمنان، ایران.

چکیده

مقدمه: اکثر زنان در دوران یائسگی در اثر کاهش ترشح هورمون استروژن، دستخوش تغییراتی می‌شوند. آتروفی ‌واژن از شایع‌ترین این تغییرات در یائسگی می‌باشد. مطالعه حاضر با هدف تعیین تأثیر کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذر کتان) بر علائم ذهنی آتروفی واژن در زنان یائسه انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی سه‌سوکور در سال 1398 بر روی 60 زن یائسه دارای علائم آتروفی ‌واژن مراجعه‌کننده به مراکز بهداشتی ‌درمانی منتخب شهر اهواز انجام شد. زنان به‌صورت تصادفی در دو گروه 30 نفره جهت دریافت کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذر کتان) و دارونما به‌مدت 8 هفته قرار گرفتند. علائم ذهنی آتروفی واژن شامل: خشکی، سوزش ‌و خارش، درد واژن و درد هنگام مقاربت با استفاده از چک‌لیست آزاردهنده‌ترین علامت (MBS) قبل از مداخله و در هفته‌های دوم، چهارم و هشتم بعد از درمان بررسی شد. تجریه‌ و‌ تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 22) و آزمون‌های من‌ویتنی، فریدمن و تی ‌مستقل انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: علائم ذهنی آتروفی واژن پس از درمان با کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذر کتان) در مقایسه با ابتدای مطالعه به‌طور معنی‌داری کاهش یافت (001/0>p). کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذرکتان) سبب کاهش معنی‌دار علائم ذهنی آتروفی واژن در زنان یائسه نسبت به کرم دارونما در هفته دوم (046/0=p)، چهارم (000/0>p) و هشتم (000/0>p) گردید.
نتیجه‌گیری: استفاده از کرم واژینال حاوی عصاره گیاهان (رازیانه، مریم‌گلی و بذر کتان) در مقایسه با کرم دارونما، نشانه‌های آتروفی واژن را در زنان یائسه کاهش می‌دهد، لذا استفاده از آن در زنان مبتلا به آتروفی واژن توصیه می‌گردد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial

نویسندگان [English]

  • Golshan Tahmasebi 1
  • Sharareh Jannesari 2
  • Foroogh Namjooyan 3
  • Malihe Nasiri 4
  • Aryan Sadeghyan 5
1 M.Sc. in Midwifery, Student Research Committee, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Instructor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant professor, Department of Pharmacongnosy, Research Center for Traditional Medicine and History of Medicine, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
4 Assistant professor, Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Student of Electrical engineering, Student Research Committee, School of Electrical and Computer Engineering, Semnan University, Semnan, Iran.
چکیده [English]

Introduction: Most menopausal women experience changes due to decreased estrogen secretion. Vaginal atrophy is one of the most common changes during menopause. This study was performed with aim to determine the effect of vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) on mental symptoms of vaginal atrophy in postmenopausal women.
Methods: The triple-blind clinical trial study was performed in 2019 on 60 postmenopausal women with symptoms of vaginal atrophy referred to the selected health centers in Ahvaz, Iran. The subjects were randomly divided into two groups of 30 women to receive vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) and placebo for eight weeks. Mental symptoms of vaginal atrophy including dryness, burning and itching, vaginal pain and pain during intercourse were assessed using the most bothersome symptom (MBS) checklist before the intervention and two, four and eight weeks after the treatment. Data were analyzed by SPSS software (version 22) and Mann-Whitney, Friedman and independent t-test. P<0.05 was considered statistically significant.
Results: After treatment with the vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) in the intervention group, the mental symptoms of vaginal atrophy significantly reduced compared to the beginning of the study (P<0.001). The vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared to placebo cream significantly reduced the mental symptoms of vaginal atrophy in postmenopausal women after two weeks (P=0.046), four weeks (P<0.000) and eight weeks (P<0.000).
Conclusion: The use of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared with placebo cream reduces the symptoms of vaginal atrophy in postmenopausal women. Therefore, this cream is recommended for women with vaginal atrophy.

کلیدواژه‌ها [English]

  • Flaxseed
  • Foeniculum vulgare
  • Menopause
  • Phytoestrogen
  • Salvia officinalis

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مجله زنان، مامایی و نازایی ایران
دوره 24، شماره 11
دی 1400
صفحه 59-69

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