تأثیر گل مغربی بر قندخون و پروفایل چربی زنان یائسه پره‌دیابتیک: کارآزمایی بالینی تصادفی شده

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

2 مربی گروه مامایی،دانشکده پرستاری و مامایی، مرکز تحقیقات مراقبت سالمندی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

3 دانشیار گروه مامایی، دانشکده پرستاری و مامایی، مرکز تحقیقات مراقبت سالمندی، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

4 استادیار گروه داخلی، دانشکده پزشکی، مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

5 استادیار گروه آمار زیستی، مرکز تحقیقات محیط کار، دانشکده بهداشت، دانشگاه علوم پزشکی رفسنجان، رفسنجان، ایران.

چکیده

مقدمه: پیشگیری از دیابت و عوارض مرتبط با آن خصوصاً در زمان یائسگی اهمیت ویژه­ای دارد، زیرا تغییرات قابل توجهی در سطح لیپیدهای خون به همراه مقاومت به انسولین رخ می­دهد که ناشی از افزایش سن می‌باشد و زمینه را برای بروز بیماری­های قلبی عروقی در زنان فراهم می‌کند. با توجه به عوارض کمتر داروهای گیاهی نسبت به داروهای شیمیایی، مطالعه حاضر با هدف بررسی تأثیر گل مغربی بر قندخون و پروفایل چربی زنان یائسه پره­دیابتیک انجام شد.
روش­کار: این مطالعه کارآزمایی بالینی تصادفی شده سه‌سوکور در سال 98-1397 بر روی 82 زن یائسه پره‌دیابتیک مراجعه‌کننده به مراکز خدمات جامع سلامت شهر رفسنجان انجام شد. گروه مداخله روزانه 2 کپسول 1000 میلی­گرم گل مغربی و گروه کنترل، دارونما را به‌مدت 3 ماه دریافت کردند. قبل و بعد از مداخله قند ‌ناشتا (FBS، HbA1C و پروفایل چربی خون (شامل تری‌گلیسیرید، کلسترول تام، لیپوپروتئین با دانسیته پایین و بالا) در دو گروه با انجام آزمایش خون بررسی شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های تی مستقل، تی زوجی و کوواریانس انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته­­ها: در این مطالعه میانگین LDL در زنان یائسه پره­دیابت دریافت­کننده کپسول گل­مغربی تفاوت آماری معنی‌داری نشان داد (049/0=p)، اما میانگین  FBS، HDL، TG و کلسترول تفاوت آماری معنی­داری را نشان نداد (05/0p>).
نتیجهگیری: مصرف روزانه 2 کپسول 1000 میلی‌گرمی گل مغربی موجب کاهش سطح LDL زنان یائسه پره‌‌دیابتیک می‌شود که می­تواند موجب کاهش ابتلاء به بیماری­های قلبی- عروقی گردد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of Evening primrose on blood sugar and lipid profile of prediabetic postmenopausal women: Randomized clinical trial

نویسندگان [English]

  • Asma Absalan 1
  • Seyede Maryam Lotfipour 2
  • Marzeyeh Lori poor 3
  • Maryam Karimi Fard 4
  • Hassan Ahmadinia 5
1 M.Sc. Student of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2 Instructor, Department of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3 Associate Professor, Department of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4 Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5 Assistant Professor, Department of Biostatistics, Occupational Environment Research Center, School of Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
چکیده [English]

Introduction: Prevention of diabetes and its associated complications is especially important during menopause because significant changes occur in blood lipid levels along with insulin resistance due to aging and predispose to cardiovascular diseases. Regarding to the lower side effects of herbal medicines than chemical medicines, this study was performed with aim to evaluate the effect of evening primrose on blood sugar and fat profile of pre-diabetic postmenopausal women.
Methods: This triple-blind randomized clinical trial was performed in 2018-2019 on 82 pre-diabetic postmenopausal women referred to the comprehensive health service centers in Rafsanjan. The intervention group received two 1000 mg capsules of evening primrose daily and the control group received placebo for three months. Before and after the intervention, fasting sugar (FBS, HbA1C) and blood lipid profile (including triglyceride, total cholesterol, low and high density lipoprotein) were assessed in the two groups by blood test. Data were analyzed by SPSS software (version 16) and independent t-test, Paired t-test and covariance test. P<0.05 was considered statistically significant.
Results: In this study, mean LDL in pre-diabetic postmenopausal women receiving evening primrose capsule showed a statistically significant difference. But the mean of FBS, HDL, TG and cholesterol didn't show a statistically significant difference.
Conclusion: Daily consumption of two 1000 mg capsules of evening primrose reduces LDL levels in pre-diabetic postmenopausal women, which can reduce the risk of cardiovascular diseases.

کلیدواژه‌ها [English]

  • Blood sugar
  • Evening Primrose
  • lipid profile
  • Menopause
  • Pre-diabetes
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