بررسی تأثیر داروی ارملوکسیفن بر ماستالژی (درد پستان): مروری نظام‌مند و متاآنالیزی از کارآزماییهای بالینی

نوع مقاله : مروری

نویسندگان

1 استادیار گروه بهداشت باروی، دانشکده پرستاری و مامایی رازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.

2 کارشناس ارشد آموزش مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی ایران، تهران، ایران.

3 دانشجوی دکتری آموزش پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران.

4 دانشیار گروه گوارش اطفال، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

5 استادیار گروه بهداشت باروی، مرکز تحقیقات مادر و کودک، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

6 مربی گروه مامایی، دانشکده پرستاری و مامایی رازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران.

چکیده

مقدمه: علی‌رغم مطالعات انجام شده به‌صورت مروری ساده یا سیستماتیک، بررسی تأثیر ارملوکسیفن بر ماستالژی به‌خوبی روشن نشده است، لذا مطالعه حاضر با هدف تعیین تأثیر ارملوکسیفن بر ماستالژی در مرور کارآزمایی­های بالینی انجام گرفت.
روش‌کار: جهت انجام این مطالعه مروری، منابع الکترونیکی لاتین از جمله Cochrane Library، ISI Web of Science، Scopus و PubMed و پایگاه­های اطلاعات علمی SID و Magiran به‌صورت سیستماتیک بدون محدودیت زمانی تا تاریخ 1 ژانویه 2021 با استفاده از کلید واژه‌های Mastalgia یا  Mastalgiasیا Mastodynia یا  Mastodyniasیا  Mammalgiaیا  Mammalgiasو  Breast Painیا  Breast Painsو Breast و  pain و  Centchromanیا  Selective Estrogen Receptor Modulators (SERM)و Systematic Review وMeta-Analysis  مورد جستجو قرار گرفتند.
یافته‌ها: 12 مطالعه به مرور نظام‌مند وارد شدند و نتایج 9 مطالعه در یک متاآنالیز ترکیب شدند. اختلاف درصد قبل و بعد از درمان با اورملوکسیفن معنی‌دار بود (001/0p<) و بهبودی 87 درصدی درد پستان را نشان داد (90/0-83/0:CI؛ 87%). بر اساس نتیجه آزمون Q، ناهمگنی بین مطالعات در حد متوسط و غیرمعنی‌دار بود (33%=I2، 14/0=p). همچنین، یافته­های دو مطالعه اثربخشی معنی‌داری از داروی اورملوکسیفن را گزارش کردند.
نتیجه‌گیری: نتایج این متاآنالیز از اثربخشی داروی ارملوکسیفن در تسکین درد پستان حمایت کردند. البته تحلیل یافته­های این مطالعات در این متاآنالیز به‌دلیل ناهمگونی بالای بین مطالعات، حجم کوچک نمونه و تعداد کم آنها باید با احتیاط تفسیر گردد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of ormeloxifene on mastalgia: A systematic review and meta-analysis of clinical trials

نویسندگان [English]

  • Masumeh Ghazanfarpour 1
  • Zari Dolatabadi 2
  • Masumeh Saeidi 3
  • Mohammad Ali Kiani 4
  • Nasibeh Roozbeh 5
  • Farzaneh Ashrafinia 6
1 Assistant Professor, Department of Reproductive Health, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
2 Assistant Professor, Department of Reproductive Health, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
3 M.Sc. in Midwifery Education, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
4 PhD Student in Medical Education, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5 Assistant professor, Department of Reproductive Health, Mother and Child Research Center, School of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
6 Instructor, Department of Midwifery, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
چکیده [English]

Introduction: Despite the studies have been published as review or systematic, the effect of ormeloxifene on mastalgia has not been well elucidated. Therefore, this study was performed with aim to determine the effect of ormeloxifene on mastalgia in clinical trial studies.
Methods: To perform this review study, the English electronic databases including ISI Web of Science, PubMed, Scopus, and Cochrane Library; also, Magiran and Scientific Information Database (SID) were searched without time limitation until January 1, 2021, by using the keywords of Mastalgia or Mastalgias or Mastodynia, or Mastodynias or Mammalgia or Mammalgias, and Breast Pain, Breast, pain, and Centchroman or Selective Estrogen Receptor Modulators (SERM), and Systematic Review, and Meta-Analysis.  
Results: Twelve studies were included in this systematic review, and the results of nine studies were combined in the meta-analysis. The percentage difference before and after treatment with ormeloxifene was significant (p<0.001), and ormeloxifene resulted in 86% improvement in breast pain relief (87%; CI:0.83-0.90). The result of the Q test showed moderate and insignificant heterogeneity between the studies (P=0.14; I2=33%). Also, the findings of the two studies have indicated significant efficacy of ormeloxifene.
Conclusion: The results of the meta-analysis supported the efficacy of ormeloxifene in relieving breast pain. However, the analysis of the findings in this meta-analysis should be interpreted with caution due to the high heterogeneity between the studies, small sample size, and the limited number of studies.

کلیدواژه‌ها [English]

  • Breast pain
  • Mastalgia
  • Ormeloxifene
  • Systematic review

مراجع

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