تأثیر تمرینات هوازی و مصرف آب انار بر سطح سرمی برخی آنزیم‌های اکسایشی و ضداکسایشی زنان نجات‌یافته از سرطان پستان

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران، تهران، ایران

2 استادیار گروه فیزیولوژی ورزشی، دانشکده ادبیات، علوم انسانی و اجتماعی، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، تهران، ایران.

3 استاد گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی تهران، تهران، ایران

چکیده

مقدمه: سرطان پستان از شایع‌ترین سرطان‌ها بوده و بیشترین میزان مرگ‌ومیر را در جهان دارد. افزایش عوامل اکسایشی و کاهش آنتی‌اکسیدان‌ها، از عوامل اصلی بروز این سرطان هستند. مطالعه حاضر با هدف بررسی تأثیر 8 هفته تمرین هوازی و مصرف آب انار بر سطح سرمی برخی آنزیم‌های مرتبط با سیستم اکسایشی/ضداکسایشی زنان نجات یافته از سرطان پستان انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی یک‌سورکور در سال 1398 بر روی 40 زن مبتلا به سرطان پستان در شهرستان رشت انجام شد. افراد به‌طور تصادفی به چهار گروه 10 نفره تمرین هوازی، مصرف آب انار، تمرین هوازی همراه با مصرف آب انار و کنترل تقسیم شدند. گروه‌های تمرینی طی 8 هفته و هر هفته 3 جلسه، تمرینات هوازی به‌مدت 90-60 دقیقه با شدت 70-50% حداکثر ضربان قلب انجام دادند. گروه‌های مصرف‌کننده آب انار نیز قبل از هر جلسه تمرین، 100 سی‌سی آب انار مصرف کردند. جهت بررسی متغیرهای پژوهش (مالون دی آلدئید، گلوتاتیون پراکسیداز، سوپر اکسید دسموتاز) 48 ساعت قبل و بعد از اجرای پروتکل تمرینی از شرکت‌کنندگان خونگیری به‌عمل آمد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 20) و آزمون‌های تحلیل واریانس یک‌طرفه، کوواریانس و آزمون تعقیبی بنفرونی انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: بر اساس نتایج، 8 هفته تمرین هوازی همراه با مصرف آب انار، باعث کاهش معنی‌دار در سطح مالون دی‌آلدئید (0001/0=p) و افزایش معنی‌دار در سطوح سوپراکسید دیسموتاز (0001/0=p) و گلوتاتیون پراکسیداز (0001/0=p) زنان مبتلا به سرطان پستان گردید. تمرین هوازی بدون مصرف آب انار تنها باعث کاهش معنی‌دار در سطح مالون دی‌آلدئید (0001/0=p) شد و با مصرف آب انار بدون تمرین، هیچ‌گونه تغییر معنی‌داری در سطوح سه متغیر مورد بررسی در زنان مبتلا به سرطان پستان مشاهده نشد.
نتیجه‌گیری: تمرین هوازی و مصرف آب انار به‌طور همزمان باعث کاهش عوامل اکسایشی و افزایش عوامل ضداکسایشی در زنان نجات‌یافته از سرطان پستان گردید.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Aerobic Exercise and Pomegranate Juice Consumption on Serum Enzyme Levels Associated With the Oxidant-Antioxidant System of Women Rescued From Breast Cancer

نویسندگان [English]

  • Babak Rouzbehan 1
  • Hossein Abed Natanzi 2
  • Khosro Ebrahim 3
  • Farshad Ghazalian 2
1 PhD Candidate in Exercise Physiology, School of Sports Sciences and Physical Education, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Assistant Professor, Department of Exercise Physiology, School of Literature, Human and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3 Professor, Department of Exercise Physiology, School of Sport Sciences and Physical Education, Tehran Shahid Beheshti University, Tehran, Iran.
چکیده [English]

Introduction: Increasing oxidative factors and reducing antioxidants is one of the main causes of breast cancer.The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and pomegranate juice on serum enzyme levels related to the Oxidant-Antioxidant system of women saved from breast cancer.
Methods: In this blinded randomized control trial which was conducted in rasht in 2019, 40 women with breast cancer were selected who were randomly were assigned into four equal groups control groups (n=10), pomegranate juice (n=10), aerobic exercise (n=10) and aerobic exercise and pomegranate juice (n=10). The aerobic exercise group and the aerobic exercise and pomegranate juice group, performed training programs including 8 weeks and 3 sessions per week with intensity 50 to 70% of the maximal heart rate for 60 to 90 minutes of training. Two groups of pomegranate juice consumers received 100 cc of pomegranate juice before each training session. In order to investigate the variables of research (MDA, SOD, GPX), blood samples were collected 48 hours before and after the intervention in fasting state. The obtained data was analyzed using of one-way analysis of variance (ANOVA) and bonferroni post hoc test analysis. The significant level was P<0/05
Results: The results showed that 8 weeks of aerobic exercise caused a significantly decreased MDA levels and significantly increased SOD and GPX levels in women with breast cancer (P = 0/0001).aerobic exercise without use of pomegranate juice, only led to a significant decrease in MDA (P=0.0001) level, and pomegranate juice consumption alone, no significant changes were observed at the three variables investigated in women with breast cancer.
Conclusion: According to the results, Aerobic exercise and consumption of pomegranate juice simultaneously, reduce oxidative factors and increase anti-oxidant factors in women Rescued from Breast Cancer

کلیدواژه‌ها [English]

  • aerobic exercise
  • pomegranate juice
  • Antioxidants
  • Free radicals
  • Breast Cancer
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