درمان‌های دارویی مدرن اختلال عملکرد جنسی در زنان: مرور نقلی

نوع مقاله : مروری

نویسندگان

1 دکترای بهداشت باروری، مرکز تحقیقات اندوکرینولوژی تولیدمثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دانشجوی دکترای تخصصی پژوهشی، مرکز تحقیقات اندوکرینولوژی تولیدمثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استاد، مرکز تحقیقات اندوکرینولوژی تولیدمثل، پژوهشکده علوم غدد درون‌ریز و متابولیسم، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: اختلال عملکرد جنسی، یکی از اختلالات رایج در زنان است. تاکنون محققان درمان‌های متعددی را جهت ارتقاء سلامت جنسی زنان مورد بررسی قرار داده‌اند، مطالعه حاضر با هدف مرور درمان‌های دارویی مدرن در اختلال عملکرد جنسی زنان انجام شد.
روش‌کار: در این مطالعه مرور نقلی، جستجو در پایگاه‌های اطلاعاتی PubMed، Scopus، Web of Science، SID، Magiran و Google Scholar تا دسامبر 2019 بدون اعمال محدودیت زمانی با استفاده از کلیدواژه‌های مربوطه انجام شد. معیارهای ورود مطالعات شامل: مطالعات مشاهده‌ای، مداخله‌ای، و مروری که مطالب متناسب با اهداف این مطالعه مروری را ارائه کرده باشند. یافته‌ها، طبق دسته‌بندی موضوعی (درمان دارویی اختلال علاقه- میل جنسی، اختلال درد ناحیه تناسلی- لگنی حین دخول و اختلال ارگاسم) مورد بحث قرار گرفت.
یافته‌ها: در این مطالعه پس از بازیابی 865 مقاله، در نهایت 63 مقاله مورد بررسی نهایی قرار گرفت. بر اساس یافته‌های مطالعات،رویکردهای درمانی موجود برای درمان اختلال علاقه- میل جنسی (برملانوتید، فلیبانسرین مورد تأیید سازمان غذا و دارو آمریکا، داروهای تأیید نشده در فاز تحقیقاتی، داروهای مهارکننده فسفو دی استراز 5، تستوسترون) و رویکردهای درمانی اختلالات درد- هنگام دخول در ناحیه تناسلی- لگنی (لغزنده کننده‌ها، اسپیمفن، پراسترون، الاگولیکس مورد تأیید سازمان غذا و دارو آمریکا و تزریق بوتاکس در مرحله تحقیقاتی) می‌باشند. در رویکرد درمانی در زمینه اختلالات ارگاسمی در زنان، تاکنون، دارویی مورد تأیید قرار نگرفته است.
نتیجه‌گیری: در حال حاضر داروهای متعددی به‌صورت تأیید شده و یا تأیید نشده برای درمان اختلال عملکرد جنسی زنان مورد استفاده قرار می‌گیرند که از طریق مکانیسم‌های مختلفی نظیر افزایش جریان خون تناسلی، بهبود سطوح آندروژن‌ها و یا از طریق عملکرد بر سیستم عصبی مرکزی، اثرات بهبود ‌دهنده بر اختلال عملکرد جنسی زنان دارند. توصیه می‌شود مطالعات بیشتری در زمینه درمان اختلال عملکرد جنسی زنان در آینده انجام شود.

کلیدواژه‌ها

عنوان مقاله [English]

Modern pharmacological treatments of sexual dysfunction in women: a narrative review

نویسندگان [English]

  • Marzieh Saei Ghare Naz 1
  • Marzieh Rostami Dovom 2
  • Fahimeh Ramezani Tehrani 3
1 PhD of Reproductive health, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 PhD student of Research, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Professor, Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences and Metabolism, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Sexual dysfunction is one of the most common disorders in women. So far, researchers have examined various treatments to promote women's sexual health. This study was performed with aim to review the modern pharmacological treatments of female sexual dysfunction in women.
Methods: In this narrative review, databases of PubMed, Scopus, Web of Science, SID, Magiran, and Google Scholar were searched up to December 2019 without time limitation using the related keywords. Inclusion criteria were observational, interventional, and review studies that provided the content appropriate to the objectives of this narrative study. Findings were discussed according to thematic classification (treatment of interest / sexual desire disorders, genito-pelvic pain-penetration disorder, and orgasmic disorder).
Results: In this study, after the evaluation of 865 studies, finally 63 studies were included in this review. According to the findings of the studies, the existing therapeutic approaches for the treatment of interest / sexual desire disorders including (US Food and Drug Administration-approved: Bremelanotide and Flibanserin, unapproved drugs including Phosphodiesterase 5 Inhibitors, Testosterone) and treatment option for genito-pelvic pain-penetration disorder including (approved by the US Food and Drug Administration: Lubricants, Ospemifene, Prosterone, Elagolix and Botox injection in the research phase), but for orgasmic disorders in women, no drug has been approved.
Conclusion: Currently, several drugs approved/unapproved have been used for treatment of sexual dysfunction in women that through different mechanisms such as increased genital blood flow, affecting androgen levels, or the central nervous system's function contributes to improving sexual dysfunction. Furture studies on the field of treatment of female sexual dysfunction are recommended.

کلیدواژه‌ها [English]

  • Medication
  • Review
  • Sexual function
  • Treatment
  • Women

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مجله زنان، مامایی و نازایی ایران
دوره 23، شماره 9
آذر 1399
صفحه 69-84

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