بررسی ارتباط سطوح ویتامین‌ها با سابقه مول هیداتیفرم در زنان: مطالعه مروری سیستماتیک

نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری بهداشت باروری، مرکز تحقیقات مادر و کودک، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

2 استادیار گروه مامایی، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی اهواز، اهواز، ایران.

4 دانشجوی دکتری بهداشت باروری، دانشکده پرستاری و مامایی، واحد کرج، دانشگاه آزاد اسلامی،کرج، ایران.

5 دانشجوی دکتری تخصصی بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: مول هیداتیفرم، یکی از مخاطرات اورژانسی در بارداری است که می­تواند زندگی زنان را در سنین باروری با خطر مرگ مواجه نماید. در مطالعات مختلف عوامل خطر متفاوتی در رابطه با بروز این بیماری ذکر شده است. یکی از این عوامل خطر، کمبودهای تغذیه­ای به‌ویژه کمبودهای ویتامینی است که می­تواند منجر به بروز این عارضه گردند. بنابراین مطالعه حاضر با هدف مرور سیستماتیک ارتباط بین سطح خونی ویتامین­ها در زنان با بروز مول هیداتیفرم انجام گرفت.
روش‌کار: در این مطالعه مرور سیستماتیک جهت یافتن مقالات مرتبط پایگاه اطلاعاتی بین‌المللیWeb of Science،Scopus ، PubMed و Embase، Google Scholar و پایگاه اطلاعاتی ملی همچون MagIran، SID، IranDoc و IranMedex با استفاده از کلمات کلیدی شامل: Hydatidiform Mole، Gestational Trophoblastic Disease، Molar Pregnancy و Vitamin با عملگرهای بولین OR و AND بدون محدودیت زمانی مورد بررسی قرار گرفتند. در نهایت دو پژوهشگر به‌طور مستقل مقالات را جهت ارزیابی کیفیت (با استفاده از چک‌لیست NOS) و استخراج یافته­های اصلی آنها مورد بررسی قرار دادند.
یافته‌ها: در نهایت 10 مقاله نهایی با حجم نمونه کلی 1134 نفر مورد ارزیابی قرار گرفت. سال انتشار مقالات از 1988 تا 2018 و تمامی مطالعات وارد شده از نوع مورد شاهدی بودند. یافته­ها نشان داد که سطوح ویتامین­های A، D، E، C، B9 و B12 با مول هیداتیفرم ارتباط دارند؛ به‌طوری‌که کاهش سطوح این ویتامین‌ها، منجر به بروز بارداری مولار می­شود. در اکثر مطالعات وارد شده، کاهش سطوح این ویتامین­ها هم در بارداری مولار کامل و هم ناکامل وجود داشت.
نتیجه‌گیری: کاهش سطوح ویتامین­های A، D، E، C، B9 و B12 می­توانند احتمال ابتلاء به حاملگی مولار را افزایش دهند. بنابراین با بررسی و تعیین کمبودهای تغذیه­ای در افراد با سابقه‌ بارداری مولار، می­توان با طراحی کارآزمایی­های بالینی، تأثیر و تجویز مکمل­های ویتامینی بر بروز مجدد را بررسی کرد.

کلیدواژه‌ها


عنوان مقاله [English]

Relationship between level of vitamins and Hydatiform Mole in Women: A Systematic Review Study

نویسندگان [English]

  • Mojdeh Banaei 1
  • Seyedeh Hanieh Alamolhoda 2
  • Maryam Beheshti Nasab 3
  • Leila Mohamadkhani Shahri 4
  • Fatemeh Bayat 5
1 PhD student of Reproductive Health, Mother and Child Research Center, School of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Assistant Professor, Department of Midwifery, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Instructor, Department of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4 PhD student of Reproductive Health, School of Nursing and Midwifery, Karaj Branch, Islamic Azad University, Karaj, Iran.
5 PhD student of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Hydatidiform mole is one of the emergency risks in pregnancy that can threaten the life of women of childbearing age with risk of death. Various studies have reported different risk factors for this disease. One of these factors is nutritional deficiency, especially vitamin deficiencies, which can lead to this condition. Therefore, this study was performed with aim to systematic review of the relationship between the blood level of vitamins in women and hydatidiform mole.
Methods: In this systematic review study, for finding the related articles, the international databases such as: Web of Science, Scopus, PubMed and Embase, Google Scholar and national databases such as: MagIran, SID, IranDoc and IranMedex were evaluated using the keywords of: "Hydatidiform Mole", "Gestational Trophoblastic Disease", "Molar Pregnancy" and "Vitamin" which were combined with the OR and AND Boolean operators without time limitation. Finally, two researchers independently reviewed the articles for assessment of the quality (by using NOS checklist) and data extraction.
Results: Finally, 10 articles were included with total sample size of 1134 women. The publication¢s year of papers was from 1988 to 2018 and all studies were case-control. The findings showed that level of vitamins A, D, E, C, B9 and B12 are associated with hydatidiform mole, so that decreasing of these vitamins leads to molar pregnancy. In most of the studies, there was decreased level of these vitamins in both complete and incomplete molar pregnancy.
Conclusion: Decreased level of vitamins A, D, E, C, B9 and B12 can increase the risk of molar pregnancy. Therefore, by examining and determining the nutritional deficiencies in women with history of molar pregnancy, we can evaluate the effect and administration of vitamin supplements on recurrence of hydatidiform mole can by designing clinical trials.

کلیدواژه‌ها [English]

  • Gestational trophoblastic disease
  • Hydatidiform mole
  • Vitamin
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