بررسی نقش هورمون آدیپونکتین و نسفاتین-1 در سندرم تخمدان پلی‌کیستیک: مروری سیستماتیک

نوع مقاله : مروری

نویسندگان

1 کارشناس ارشد مامایی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

2 دانشجوی دکتری بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران. مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی آزاد بابل، بابل، ایران.

3 دانشجوی دکتری بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی گیلان، رشت، ایران.

چکیده

مقدمه: آدیپونکتین و نسفاتین هورمون‌هایی هستند که از بافت چربی در پاسخ به محرک‌های خارج سلولی ترشح می‌شوند و در تنظیم تعادل انرژی، متابولیسم لیپید و حساسیت به انسولین نقش دارند. مطالعه مروری حاضر با هدف بررسی تأثیر آدیپونکتین و نسفاتین-1 در سندرم تخمدان پلی‌کیستیک انجام شد.
روش‌کار: در این مطالعه مروری برای یافتن مقالات، جستجو در بانک‌های اطلاعاتی Pubmed، Scopus، Google Scholar و SID با کلید واژه‌های Adiponectin (آدیپونکتین)، Nesfatin-1 (نسفاتین ۱) و (سندرم تخمدان پلی‌کیستیک)  PCOSاز سال 2003 تا 2017 انجام شد و این مطالعه بر اساس چک‌لیست PRISMA نگاشته شد. کیفیت مقالات استخراج شده بر اساس فهرست مندرجات STORBE، CONSORT و CASP ارزیابی و در نهایت 21 مقاله مورد بررسی قرار گرفت.
یافته‌ها: اکثر مطالعات نشان دادند که سطح آدیپونکتین در افراد مبتلا به PCOS کاهش می‌یابد. همچنین مطالعات نتایج متناقضی در ارتباط با سطح نسفاتین و PCOS نشان دادند.
نتیجه‌گیری: مطالعات نشان دادند که احتمالاً آدیپونکتین و نسفاتین در PCOS نقش دارند و احتمالاً با کنترل و تنظیم این هورمون در بدن می‌توان به درمان افراد مبتلا به PCOS کمک کرد و یا از ابتلای به آن جلوگیری کرد و بارِ تحمیلی اقتصادی به خانواده و جامعه را کاهش داد.

کلیدواژه‌ها

عنوان مقاله [English]

Role of adiponectin and nsafatin_1 hormones in polycystic ovary syndrome: systematic review

نویسندگان [English]

  • Narjes Hasanheyvadi 1
  • Fatemeh Razavinia 1
  • Fatemeh Yahyavi Koochaksaraei 2
  • Sedighe Rezaei Chamani 3
1 M.Sc. in Midwifery, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2 Ph.D student, Department of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Instructor, Department of Midwifery, School of Nursing and
3 Ph.D student, Department of Reproductive Health, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
چکیده [English]

Introduction: Adiponectin and nesfatin are the hormones which secret from adipose tissue in response to extracellular stimuli. Lipid metabolism and insulin sensitivity have role in regulating energy balance. This review study was performed with aim to investigate the effect of adiponectin and nesfatin-1 in polycystic ovary syndrome (PCOS).
 Methods: In this review article, to find the articles, search was performed in databases of pubmed, google scholar, Scopus, SID with the keywords of Adiponectin, Nesfatin, and polycystic ovary syndrome from 2003 to 2017. This study was written based on PRISMA checklist. The quality of the extracted articles was evaluated based on the STORBE, CONSORT and CASP checklist of contents, and ultimately 21 articles were assessed.
 Results: In most studies, adiponectin levels have been shown to decrease in patients with PCOS. Also, the studies have shown contradictory results about nesfatin levels and PCOS.
Conclusion: Studies have shown that adiponectin and nesfatin may play a role in PCOS and likely control and regulate this hormone in the body and can help to treat people with PCOS or prevent it and reduce the economic burden on the family and society.

کلیدواژه‌ها [English]

  • Adiponectin
  • Nesfatin
  • PCOS

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مجله زنان، مامایی و نازایی ایران
دوره 23، شماره 4
تیر 1399
صفحه 75-88

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