نوع مقاله : مروری
نویسندگان
1 دانشجوی کارشناسی ارشد علوم و صنایع غذایی، کمیته تحقیقات دانشجویی، دانشکده علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی،
2 استادیار گروه تغذیه سلولی مولکولی، دانشکده علوم تغذیه و صنایع غذایی، انستیتو تحقیقات تغذیه ای و صنایع غذایی کشور، دانشگاه علوم
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Introduction: Infertility is defined as the failure to achieve pregnancy after one year of regular, unprotected intercourse. Assisted reproductive technologies (ART) are effective options for infertility treatment. In recent years, the role of nutrition and lifestyle in enhancing treatment outcomes has received increasing attention. Soy isoflavones (phytoestrogens), due to their estrogen-like properties, have shown potential in improving female fertility. This systematic review aimed to investigate the effects of both soy-based dietary products and phytoestrogen supplements on ART-related outcomes
Methods: A comprehensive search was conducted in both English and Persian databases including Medline, Embase, Google Scholar, Web of Science, Science Direct, Scopus, Magiran, SID, ISC, and Cochrane up to March 2025, using keywords related to infertility, soy, phytoestrogens, isoflavones, and ART. Both dietary soy products and phytoestrogen supplements were considered as interventions.
Results: Five studies with a total of 1,085 participants were included. In women, soy consumption was associated with increased clinical pregnancy rates, improved implantation, and higher live birth rates. These benefits were more evident with moderate doses and in the presence of clomiphene citrate or exposure to endocrine-disrupting compounds. Soy also appeared to counteract the adverse effects of certain environmental toxins. However, soy intake by men showed no significant impact on ART outcomes.
Conclusion: The use of soy-based products—whether from dietary sources or as phytoestrogen supplements—may enhance ART outcomes in women, particularly in improving clinical pregnancy, fertilization, implantation, and live birth rates.
کلیدواژهها [English]