تأثیر 12 هفته تمرین هوازی ترکیبی بر سطوح سرمی گاماگلوتامیل ترانسفراز کبدی و شاخص های قندی زنان دیابتی میانسال

نوع مقاله: اصیل پژوهشی

نویسندگان

مربی گروه دروس عمومی، دانشکده علوم پایه، دانشگاه صنعتی خاتم الانبیاء بهبهان، بهبهان، ایران.

چکیده

مقدمه: هپاتوپاتی دیابتی به عنوان یک ضایعه بسیار مهم توسط دانشمندان متعددی مورد بررسی قرار گرفته است که اخیراً نقش تمرینات ورزشی منظم در پیشگیری از آن مطرح شده است. از این ‌رو مطالعه حاضر با هدف بررسی تأثیر تمرینات هوازی ترکیبی بر میزان گاماگلوتامیل ترانسفراز (GGT) کبدی و برخی شاخص‌های گلیسمی (انسولین، مقاومت به انسولین، گلوکز ناشتا و دو ساعته) سرم زنان میانسال دیابتی انجام شد.
روش‌کار: این مطالعه نیمه تجربی در سال 1392 بر روی 30 نفر از زنان بیمار دیابتی نوع دو در شهرستان بهبهان انجام شد. افراد به صورت تصادفی به دو گروه شاهد و تجربی تقسیم شدند. آزمودنی‌های گروه‌های تجربی 12 هفته (3 روز در هفته با شدت 70-55% حداکثر ضربان قلب و 50-35 دقیقه در هر جلسه) تمرین کردند. در ابتدای دوره و 48 ساعت پس از دوره پژوهش نمونه‌های خون جهت اندازه‌گیری GGT، انسولین، مقاومت به انسولین، گلوکز ناشتا و دو ساعته گرفته شد. تجزیه و تحلیل داده‌ها با استفاده از نرم افزار  SPSS(نسخه 18) و آزمون های کولموگروف اسمیرنوف، تی مستقل و لون انجام شد. میزان p کمتر یا مساوی 05/0 معنی دار در نظر گرفته شد.
یافته‌ها: 12 هفته تمرین هوازی بر سطح انسولین سرم آزمودنی‌ها تأثیر معناداری نداشت (05/0≤p)، در صورتی که بر GGT، مقاومت به انسولین، گلوکز ناشتا و گلوکز دو ساعته آزمودنی‌ها تأثیر معناداری داشت (05/0≥p).
نتیجه‌گیری: در بیماران دیابتی نوع دو تمرین هوازی می‌تواند باعث کاهش مقاومت به انسولین شود و همچنین میزان آنزیم کبدی GGT که مشخصه آسیب سلولی کبدی است نیز به دنبال کاهش مقاومت به انسولین و گلوکز خون کاهش می‌یابد که نشانه بهبود نسبی وضعیت کبد در زنان دیابتی نوع دو است.
 

کلیدواژه‌ها


عنوان مقاله [English]

Effect of combined aerobic exercise on serum level of liver gamma glutamil transferase and glycemic index of middle-aged diabetic women

نویسندگان [English]

  • Asieh sadat Mousavian
  • Hassan Darvakh
Instructor of General courses, School of Basic Sciences, Behbahan Khatamolanbia University of Technology, Behbahan, Iran.
چکیده [English]

Introduction: Diabetic hepatophaty has been investigated by many researchers. Recently, the role of regular exercise has been considered to prevent it. So, this study was performed with aim to evaluate the effect of combined aerobic exercise on serum level of liver gamma-glutamil transferase (GGT) and glycemic index (insulin, insulin resistance, fasting and two-hour glucose) in middle-aged diabetic women.
Methods: This semi-experimental study was performed on 30 women with type 2 diabetes in Behbahan city. They were randomly divided into two groups of cases and control. The subjects in the experimental group performed 12 weeks exercise (3 days a week with an intensity of 55-70% maximal heart rate for 35-50 min per session) has been trained. At the beginning of the study and 48 hours after that, blood sample was taken to measure GGT, insulin, insulin resistance, fasting and two-hour glucose. Data analysis was performed using SPSS software (version 18), and Kolmogorov-Smirnov test, independent t-test and loan test. PResults: 12 weeks aerobic training was not significantly effective on serum insulin levels of the subjects (P≥0.05), while it has significant effect on insulin resistance, GGT, fasting glucose and two-hour glucose (P≤0.05).
Conclusion: The aerobic training in type 2 diabetic patients reduces resistance insulin and also, the rate of liver enzyme GGT which is the sign of liver cell damage is reduced following decreased resistance insulin and blood glucose that is the sign of relative improvement of liver status in women with type 2 diabetes.

کلیدواژه‌ها [English]

  • aerobic exercise
  • Gamma­ glutamine transferase
  • Glycemic Index
  • Type 2 diabetes mellitus
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