تأثیر هشت هفته تمرین هوازی و مصرف عصاره کاسنی بر سطوح سرمی آنزیم‌های آلانین‌آمینوترانسفراز و آسپارتات آمینوترانسفراز در زنان مبتلا به کبد‌چرب

نوع مقاله: اصیل پژوهشی

نویسندگان

1 دانشیار گروه فیزیولوژی ورزش، دانشکده تربیت‌بدنی، دانشگاه صنعتی شاهرود، شاهرود، ایران.

2 دانشجوی کارشناسی ارشد فیزیولوژی ورزشی، دانشکده تربیت‌بدنی، دانشگاه صنعتی شاهرود، شاهرود، ایران.

3 دانشجوی دکترای فیزیولوژی ورزشی، دانشکده تربیت‌بدنی، دانشگاه حکیم سبزواری، سبزوار، ایران.

چکیده

مقدمه: بیماری کبد‌چرب، یکی از بیماری‌های متابولیک در حال افزایش است. تعدیل سبک زندگی مانند تغذیه سالم و ورزش، برای بیماران مبتلا به کبد‌چرب توصیه ‌شده و کاسنی به دلیل اثرات محافظتی بر کبد مورد توجه قرار گرفته است. مطالعه حاضر با هدف بررسی تأثیر 8 هفته تمرین‌ هوازی به همراه مصرف عصاره کاسنی، بر سطوح سرمی آنزیم‌های آلانین آمینوترانسفراز و آسپارتات آمینوترانسفراز در زنان مبتلا به کبد‌چرب انجام شد.
روش‌کار: این مطالعه نیمه تجربی با طرح پیش‌آزمون و پس‌آزمون در سال 1393 بر روی 30 زن مبتلا به کبد‌چرب در شهرستان بردسکن انجام شد. افراد به ‌طور تصادفی به سه گروه 10 نفره تمرین + مکمل، تمرین ‌+ دارونما و مکمل تقسیم شدند. گروه‌های تمرین به اجرای برنامه تمرین هوازی با تواتر 3 جلسه در هفته و به مدت 8 هفته پرداختند. آزمودنی‌ها در طی این دوره روزانه 200 میلی‌لیتر عصاره گیاه کاسنی (1-ml100-5/2) یا دارونما دریافت کردند. در ابتدای دوره و 48 ساعت پس از دوره پژوهش نمونه‌های خون جهت اندازه‌گیری آلانین ‌آمینوترانسفراز و آسپارتات‌ آمینو‌ترانسفراز گرفته شد. تجزیه و تحلیل داده ها با استفاده از نرم‌افزار آماری SPSS (نسخه 20) و آزمون‌های تحلیل واریانس و تی همبسته و LSD‌ انجام شد. میزان p کمتر یا مساوی 05/0 معنی دار در نظر گرفته شد.
یافته‌ها: بین هر سه گروه تفاوت معناداری در کاهش سطوح سرمیALT و AST وجود داشت (0001/0=p) و این کاهش در گروه تمرین + مکمل در مقایسه با سایر گروه‌ها بیشتر بود (05/0≥p).
نتیجه‌گیری: مصرف همزمان مکمل کاسنی به همراه تمرین هوازی می‌تواند باعث کاهش بیشتر آنزیم‌هایALT و AST در زنان مبتلا به کبد‌چرب شود.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of 8 weeks of Aerobic Training and using Chicory extractive supplementation on Serum levels of ALT and AST Enzymes in women with Fatty Liver

نویسندگان [English]

  • Ali Hasani 1
  • Razieh Ansari 2
  • Aliasghar Mazani 3
1 Associate Professor, Department of Sport physiology, School of Physical Education, Shahrood University of Technology, Shahrood, Iran
2 MSc student in Sport Physiology, Department of Physical Education, Shahrood University of Technology, Shahrood, Iran.
3 PhD student of Sport Physiology, Department of Physical Education, Hakim Sabzevary University, Sabzevar, Iran.
چکیده [English]

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a growing metabolic disease. Life-style modifications such as healthy diet and sport have been recommended for patients with fatty liver. Chicory has drawn attention for its hepatoprotective effects. This study was performed with aim to investigate the effect of eight weeks aerobic training along with chicory extractive supplementation on serum levels of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) enzymes in women with fatty liver.
Methods: Methods: This semi-experimental pre and post-test study was performed on 30 NAFLD women in Bardeskan city in 2014. They were randomly divided into three groups of 10 cases: 1- training + supplement, 2- training + placebo, 3- supplement. Training groups performed training program comprised of aerobics exercises, 3 sessions per week for 8 weeks. During the experimental period, participants received either 200 mL daily chicory extractive (2.5g/100mL) for 8 weeks or placebo. Prior and 48h after the experimental period, blood samples were taken to be analyzed for serum levels of ALT and AST. Data was analyzed by SPSS software (version 20), and analysis of variance and coefficient t and LSD. PResults: There was significant difference among three groups in decreased serum levels of ALT and AST (P=0.0001), and this decrease was higher in training + supplement group than other groups (P≤0.05)
Conclusion: Simultaneous consumption of chicory supplementation along with aerobic training have more effect on AST and ALT reduction in women with fatty liver.

کلیدواژه‌ها [English]

  • Aerobic training
  • Alanine Aminotransferase
  • Aspartate Aminotransferase
  • Chicory
  • Fatty liver
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