اهمیت سروتیپ‌های کلامیدیا تراکوماتیس در ارتباط با عفونت ناشی از آن؛ مطالعه مروری

نوع مقاله: مروری

نویسندگان

1 استاد میکروبیولوژی، گروه زیست شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران. مرکز تحقیقات بیوتکنولوژی و علوم زیستی، دانشگاه شهید چمران اهواز، اهواز، ایران.

2 کارشناسی ارشد میکروبیولوژی، گروه زیست شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران.

چکیده

مقدمه: کلامیدیا تراکوماتیس غالباً از طریق مقاربت جنسی منتقل می­شود و مانند سایر بیماری­های گروه STD (منتقل شونده جنسی)، در درجه اول افراد جوان و فعال جنسی را تحت تأثیر قرار می­دهد و به دلیل ایجاد عوارض در دوران بارداری حائز اهمیت است. مطالعه مروری حاضر با هدف بررسی نقش واریته­های سرمی این باکتری و ارتباط آن با عوارض ناشی از عفونت آن انجام شد.
روش­­کار: در این مطالعه مروری داده­ها از بانک­های اطلاعاتی Web of Science، Google Scholar، PubMed، Sciencedirect، ISC و magiran با استفاده از کلید واژه­های Chlamydia trachomatis، STD، Prevalence، Serovar، Infertility، کلامیدیا تراکوماتیس، عفونت­های تناسلی، ناباروری و واریته­های سرمی گردآوری شد و با تأکید بر مقالات انگلیسی زبان چاپ شده در 5 سال ­اخیر، از 66 مقاله استفاده گردید.
یافته­ها: تعیین پراکنش سویه­های مختلف این باکتری درون سلولی اجباری در مناطق جغرافیایی مختلف می­تواند راهنمای مناسبی برای طراحی برنامه­های اپیدمیولوژیک به منظور کنترل عفونت کلامیدیایی و به دنبال آن کنترل STD باشد. تقریباً تمامی مطالعات انجام شده در این زمینه نشان داده­اند که واریته­های سرمی D تا K عمدتاً با عفونت­های ادراری- تناسلی در ارتباط هستند و واریته سرمی E، واریته سرمی غالب مرتبط با عفونت دهانه رحم، واژن و مجاری ادراری- تناسلی است، ولی شیوع آن در مطالعات بین 50-20 درصد متغیر است. توزیع جغرافیایی گروه­های سرولوژی در سراسر جهان در سطح ملی بسیار مشابه ولی در شهرها دارای اختلافاتی است. شایع­ترین واریته­های سرمی در سراسر جهان E، D و F هستند.
نتیجه­گیری: یافته­های موجود ارتباط بین واریته­های سرمی ادراری- تناسلی و شدت علائم بالینی و مدت زمان عفونت­های کلامیدیا تراکوماتیس را نشان داده‌اند؛ اگرچه در این میان داده­های متناقضی نیز گزارش شده است.

کلیدواژه‌ها


عنوان مقاله [English]

The importance of Chlamydia trachomatis serotypes in its infection: a review

نویسندگان [English]

  • Hossein Motamedi 1
  • Mahshid Aria 2
1 Professor, Department of Microbiology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Biotechnology and Biological Science Research Center, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
2 M.Sc. of Microbiology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
چکیده [English]

Introduction. Chlamydia trachomatis is mainly transmited by sexusal contact and similar to other STDs (sexually transmitted diseases) affect primarily young and sexually active persons which due to its undesirable effects in pregnancy is of great importance. The aim of this study is review the role of different C. trachomatis serovars and their relaition with infection consequents.
Methods. This study was a review of data collected from scientific databases including Web of science, Google scholar, PubMed, Sciencedirect, ISC and magiran using the following keywords: Chlamydia trachomatis, serovar, STD, prevalence and infertility. After initial search with emphasis on the published English papers over the last 5 years, 66 articles were included.
Results. The distribution of different strains of this intracellular bacterium in different parts of the world can be a suitable clue for planning epidemiologic programs for control of this infection and consequently other STDs. All studies on this subject nearly revealed that E serovar is the dominant serovar in the infection of cervix, vagina and uro-genital system but its prevalence varies between 20 – 50% in different researches.
Conclusion. The distribution of serological groups of C. trachomatis around the wolrd is very similar at national scale but are different between cities. The most prevalent serovars are E, D and F. Various studies have shown the relation of serovars involved in urogenital infections with clinical symptoms severity and the duration of C. trachomatis infection; however contradictory data have been reported.

کلیدواژه‌ها [English]

  • Chlamydia trachomatis
  • Sexually transmitted disease
  • Infertility
  • Serogroup
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