کلونیزاسیون استرپتوکوکوس آگالاکتیه در زنان باردار ایران: مرور نظام‌مند

نوع مقاله: مروری

نویسندگان

1 دانشجوی دکتری تخصصی باکتری شناسی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 دانشیار ویروس شناسی پزشکی، مرکز تحقیقات مقاومت های میکروبی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: استرپتوکوکوس آگالاکتیه می‌تواند در رکتوواژینال زنان باردار کلونیزه شده و با انتقال به نوزاد، منجر به بیماری‌های زودرس نوزادی خطرناک مانند سپسیس و پنومونی شود. برای پیشگیری از این عوارض باید پروفیلاکسی آنتی‌بیوتیکی در مادران باردار حامل باکتری انجام شود. آمارهای متفاوتی از میزان کلونیزاسیون این باکتری در ایران وجود دارد و میزان شیوع کلی آن مشخص نیست. مطالعه مروری حاضر با هدف بررسی میزان کلونیزاسیون باکتری در ایران انجام شد.
روش‌کار: در مطالعه مروری حاضر میزان کلونیزاسیون زنان باردار در ایران با استرپتوکوکوس آگالاکتیه با بررسی مقالات موجود در پایگاه‌های اطلاعاتیGoogle Scholar ،Scopus ،PubMed IranMedex ،ISC ، ISI Web of Knowledge، MedLib و با استفاده از کلمات کلیدی Streptococcus agalactiae colonization، group B streptococcus colonization، neonatal infection، prognant women و Iran بدون محدودیت زمانی انجام شد. 32 مقاله بر اساس بررسی کلونیزاسیون مادران باردار توسط استرپتوکوکوس آگالاکتیه در مناطق مختلف ایران وارد مطالعه شدند. تجزیه و تحلیلداده‌ها با نرم‌افزار آماری SPSS (نسخه 16) انجام شد.
یافته‌ها: تعداد 10548 زن باردار در 32 مطالعه و در 17 شهر بررسی شدند. از این تعداد 1568 مورد با باکتری کلونیزه بودند. میزان شیوع کلی 50/15% تخمین زده شد که بیش‌ترین تعداد مربوط به شهر سنندج (75%) و کمترین تعداد مربوط به شهر کاشان (6/7%) بود.
نتیجه‌گیری:غربالگری تمام زنان باردار از نظر کلونیزاسیون استرپتوکوکوس آگالاکتیه، در هفته 37-35 بارداری و ارائه اطلاعات اپیدمیولوژیک به سیستم بهداشت و درمان جهت اقدامات پیشگیرانه مانند تولید واکسن بر اساس سروتیپ شایع، مفید خواهد بود، همچنین در مطالعات بالینی ارتباط بین کلونیزاسیون استرپتوکوکوس و عوارض مادری و نوزادی بررسی شود.

کلیدواژه‌ها


عنوان مقاله [English]

Colonization rate of Streptococcus Agalactiae in pregnant women in Iran: A systematic review

نویسندگان [English]

  • Arshid Yousefi Avarvand 1
  • Farzad Khademi 1
  • Kiarash Ghazvini 2
  • Mahboube Nakhzari Moghadam 1
  • Zahra Meshkat 2
1 PhD student in Medical Bacteriology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Associate Professor, Department of Medical Virology, Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Streptococcus agalactiae can be colonized in rectovaginal of pregnant women and subsequently with transmission to infant's results in serious early neonatal diseases such as sepsis and pneumonia. To prevent these complications, antibiotic prophylaxis in pregnant women carrying the bacteria should be performed. There are various statistics about the colonization rate of these bacteria in Iran and the total prevalence is unclear. This review study was performed with aim to evaluate the bacterial colonization in Iran.
Methods: In this review study, colonization rate of Streptococcus agalactiae in pregnant women in Iran was evaluated by search in databases of Google Scholar, Scopus, PubMed, Iran Medex, ISC, ISI Web of Knowledge and MedLib by using the keywords of Streptococcus agalactiae colonization, group B streptococcus colonization, neonatal infection, pregnant women and Iran without time limitation. 32 articles were included in the study based on the rectovaginal colonization rate of pregnant women by Streptococcus agalactiae in different areas of Iran. Data analysis was performed using SPSS software (version 16).
Results: A total of 10548 pregnant women in 17 cities at 32 studies were investigated. Among them, 1568 were colonized with bacteria. The total prevalence rate was estimated 15.5%; the highest and lowest prevalence of Streptococcus agalactiae was observed in Sanandaj (75%) and Kashan (7.6%), respectively.
Conclusion: Screening of Streptococcus agalactiae in all pregnant women at 35-37 weeks of pregnancy and providing epidemiological data to the health care system for preventive measures such as the development of vaccines based on common serotype would be useful. Also, the relationship between Streptococcus colonization and maternal and neonatal complications be evaluated in clinical studies.

کلیدواژه‌ها [English]

  • Iran
  • Pregnant Women
  • Streptococcus agalactiae
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