تأثیر گیاه رازک بر علائم وازوموتور یائسگی: یک مطالعه مرور سیستماتیک و متاآنالیز

نوع مقاله: مروری

نویسندگان

1 دانشجوی دکترای تخصصی، کمیته پژوهشی دانشجویان، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 دکترای تخصصی بهداشت باروری، مرکز تحقیقات مراقبت‌های مادر و کودک، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران.

چکیده

مقدمه: علائم وازوموتور یکی از شایع‌ترین مشکلات زنان در دوران یائسگی است و ممکن است کیفیت زندگی زنان را تحت تأثیر قرار دهد. گیاه رازک حاوی ترکیبات فیتواستروژنی قوی می‌باشد که در کاهش علائم یائسگی مؤثر است. مطالعه مرور سیستماتیک و متاآنالیز حاضر با هدف بررسی تأثیر گیاه رازک بر علائم وازوموتور یائسگی انجام شد.
روش‌کار: در این مطالعه مرور سیستماتیک پایگاه‌های اطلاعاتی شامل MEDLINE، EMBASE، ProQuest،Web of Science ، Scopus،Uptodate ،The Cochrane Central Register of Controlled Trials ، PsycINFO، Google scholar و (CINAHL (EBSCO، با استفاده از کلمات کلیدی "یائسگی"، "رازک"، "گرگرفتگی" و "علائم وازوموتور" جستجو شدند و تمام کارآزمایی‌های بالینی از سال 2000 میلادی تا پایان دسامبر سال 2015 وارد مطالعه شدند. هیچ محدودیتی در زبان انتشار مقالات وجود نداشت. در نهایت تعداد 4 مقاله استخراج و وارد مطالعه شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار STATA (نسخه 10) انجام شد. از آزمون Egger برای سوگیری انتشارات و از شاخص I2 و کای اسکوئر جهت بررسی همگنی بین مطالعات استفاده شد. جهت بررسی معنی‌داری تفاوت میانگین‌ها از Z-value و P-value استفاده شد.
یافته‌ها: از 340 مقاله در بررسی اولیه، در نهایت 4 مقاله وارد مطالعه شدند. ترکیب داده‌های مطالعات مختلف بر مبنای مدل تصادفی نشان داد گیاه رازک باعث بهبود علائم وازموتور یائسگی می‌شود و تعداد و شدت دوره‌های گرگرفتگی و تعریق شبانه را کاهش می‌دهد (05/0>p).
نتیجه‌گیری: گیاه رازک می‌تواند به عنوان یک درمان جایگزین مناسب در بهبود علائم وازوموتور یائسگی در نظر گرفته شود.

کلیدواژه‌ها


عنوان مقاله [English]

The effects of Humulus Lupulus L.)Hops) on Menopausal Vasomotor Symptoms: A Systematic Review and Meta- analysis

نویسندگان [English]

  • Fatemeh Abdi 1
  • Nasibeh Roozbeh 2
1 PhD student, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 PhD in Reproductive Health, Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
چکیده [English]

Introduction: Vasomotor symptom is one of the most commonly problems of women during menopause and can negatively affect women’s quality of life. Humulus Lupulus L.) Hops) has powerful Phytoestrogenic compounds which are effective in the alleviation of menopausal symptoms. This systematic review and meta-analysis study was performed with aim to evaluate the effects of hops on vasomotor symptoms of menopause.
Methods: In this systematic review, databases of Medline, Embase, ProQuest, Web of Science, the Cochrane Central Register of Controlled Trials, PsycINFO, Scopus, Uptodate, Google Scholar, and CINAHL (EBSCO) were searched using the keywords of “menopause”, “hops”, “hot flash”, and “vasomotor symptoms” and all clinical trials published between 2000 to the end of December 2015 were included in the study. No limitation was imposed on the papers’ language. Finally, four articles were extracted and evaluated. Data was analyzed by Stata software (version 10). Publication bias was assessed by Egger tests and heterogeneity was assessed by chi-square and I2 index. Z-value and P-value were used for evaluation of the significance of mean differences.
Results: Among 340 initially assessed papers, finally, 4 articles were entered to the study. Combining data from different studies based on random model indicated that hop alleviated vasomotor symptoms of menopause and reduced the frequency and duration of hot flushes and night sweats (P<0.05).
Conclusion: Hops can be used as an alternative treatment in the management of vasomotor symptoms of menopause.

کلیدواژه‌ها [English]

  • Hops
  • hot flashes
  • Menopause
  • Vasomotor
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