تأثیر برخی هورمون‌های مرتبط با سندرم تخمدان پلی کیستیک بر کیفیت زندگی وابسته به سلامت

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی دکترای پژوهشی مذهب و سلامت، مرکز تحقیقات ناباروری، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

2 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

3 استادیار گروه زنان و مامایی، مرکز تحقیقات ناباروری، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

4 کارشناس ارشد مهندسی بهداشت حرفه ای، دانشکده بهداشت، دانشگاه علوم پزشکی شهید صدوقی یزد، یزد، ایران.

5 دانشجوی دکترای آمار زیستی، کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

6 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی همدان، همدان، ایران.

7 کارشناس ارشد آموزش بهداشت و ارتقاء سلامت، مرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی شهید صدوقی یزد، یزد، ایران.

چکیده

مقدمه: سندرم تخمدان پلی کیستیک یکی از اختلالات شایع آندوکرینی زنان است که به دلایل مختلف از جمله تغییرات هورمونی می‌تواند باعث آشفتگی روانی و افت کیفیت زندگی شود. با مروری بر مطالعات انجام شده در ایران فقدان توجه به کیفیت زندگی افراد مبتلا به عنوان یک چالش بزرگ به چشم می‌خورد، لذا مطالعه حاضر با هدف بررسی اثر برخی هورمون‌های مرتبط با سندرم تخمدان پلی کیستیک بر کیفیت زندگی مبتلایان انجام شد.
روش کار: این مطالعه مقطعی در سال 1391 بر روی 60 نفر از زنان مراجعه کننده به درمانگاه شهید مطهری شهر شیراز که مبتلا به سندرم تخمدان پلی کیستیک بودند، انجام گرفت. برای سنجش کیفیت زندگی افراد از پرسشنامه PCOSQ استفاده شد. همچنین جهت بررسی تأثیر PCOS بر هورمون‌های استرادیول، تستوسترون و FSH، 10 میلی لیتر خون در روزهای سوم تا پنجم سیکل قاعدگی از افراد گرفته شد و با روش‌های رادیوایمونواسی و الکتروایمونواسی، میزان هورمون‌ها اندازه‌گیری شد. تجزیه و تحلیل داده‌ها با استفاده از نرم افزار آماری SPSS (نسخه 18) و آزمون‌های کای اسکوئر، همبستگی پیرسون، تی زوجی و آنالیز واریانس سه طرفه انجام شد. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.
یافته ها: اختلالات قاعدگی کم‌ترین میانگین نمره را از میان حیطه‌های پرسشنامه PCOSQ کسب کرد که نشانه مهم‌ترین نگرانی افراد مبتلا می باشد و حیطه های بعدی به ترتیب از ضعیف‌ترین امتیاز شامل: حیطه وزن، مشکل ناباروری، عاطفی و هیرسوتیسم بود. در بررسی رابطه بین پارامترهای اندازه‌گیری شده با حیطه‌های مختلف کیفیت زندگی، تنها بین حیطه عاطفی با تستوسترون همبستگی معکوس و معنی‌داری مشاهده (049/0=p، 355/0-=r)، در سایر موارد ارتباط معنی‌داری مشاهده نشد (05/0<p).
نتیجه‌گیری: با توجه به وجود ارتباط معکوس و معنی دار بین هورمون تستوسترون و حیطه عاطفی کیفیت زندگی، پیشنهاد می شود که بر اساس روند تغییرات هورمون تستوسترون، به این بُعد از کیفیت زندگی نیز توجه ویژه داشت و برای آن جلسات آموزشی و مشاوره ای مناسب را طراحی و اجرا نمود.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of some hormones related to polycystic ovary syndrome on health-related quality of life

نویسندگان [English]

  • Sedigheh Forouhari 1
  • Zhaleh Heidari 2
  • Zohreh Tavana 3
  • Hamideh Mihanpour 4
  • Mehrab Sayadi 5
  • Arezoo Shayan 6
  • Noushin Yoshany 7
1 PhD student of Religion and Health Research, Infertility Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2 M.Sc. Student in Midwifery, Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Assistant Professor, Department of Obstetrics and Gynecology, Infertility Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4 M.Sc. in Occupational Health Engineering, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5 PhD student in Biostatistics, Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
6 Instructor, Department of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
7 M.Sc. in Health Education & Health Promotion, Social Determinants of Health Research Center, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd , Iran.
چکیده [English]

Introduction: Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine disorders that due to different factors such as hormonal changes can cause mental distress and decreased quality of life. A review of the studies conducted in Iran shows the lack of attention to the quality of life in these patients as a big challenge. Therefore, this study was performed with aim to assess the effect of some polycystic ovary syndrome-related hormones on quality of life in these women.
Methods: This cross-sectional study was performed on 60 women with Polycystic Ovarian Syndrome referred to Shiraz Shahid Motahari clinic in 2012. PCOSQ questionnaire was used to assess the patients' quality of life. To evaluate the effect of PCOS on FSH, testosterone and estradiol, 10 ml blood samples were taken from the participants on days 3-5 of the menstrual cycle. Serum levels of hormones were determined by radioimmunoassay (RIA) and electroimmunoassay (EIA). Data was analyzed by SPSS software (version 18) and chi-square, Pearson correlation, t-test and Three-Way ANOVA. PResults: Menstrual disorders obtained lowest mean score in the areas of PCOSQ that indicates the most important concern of patients, and the areas including weight, infertility, emotional disorders, and hirsutism were the next weakest areas, respectively. In the evaluation of relationship between various measured parameters with different areas of quality of life, inverse significant correlation was found only between testosterone and emotional area (P=0.049, r=-0.355) and no significant relation was observed in other cases (P>0.05).
Conclusion: Regarding inverse significant correlation between testosterone and emotional area of quality of life, it is recommended that based on the hormonal changes of testosterone, special attention be paid to this dimension of quality of life and appropriate educational and counselling sessions be designed and implemented.

کلیدواژه‌ها [English]

  • Polycystic ovary syndrome
  • Quality of life
  • Sexual hormones
  • Hyperandrogenemia
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