چالش های باروری و ملاحظات مرتبط با فناوری کمک باروری در زوجین مبتلا به هپاتیت B: (مقاله مروری)

نوع مقاله: مروری

نویسندگان

1 مربی گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.

2 دانشجوی دکترای تخصصی بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

3 استاد گروه غدد تولید مثل و جنین شناسی، مرکز تحقیقات باروری ناباروری، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

چکیده

مقدمه: ویروس هپاتیت B شایع‌ترین ویروس تهدید کننده سلامت انسان و یک بیماری منتقله از راه جنسی و خونی است. مطالعات بیانگر اثرات منفی عفونت های ویروسی بر باروری انسان بوده و در حال حاضر استفاده از تکنیک‌های کمک باروری در افراد مبتلا به عفونت های منتقله جنسی در حال افزایش است. مطالعه حاضر با هدف بررسی چالش‌های باروری و پیامد فناوری کمک باروری زوجین مبتلا به عفونت هپاتیت B و چگونگی انتقال عفونت از سلول‌های جنسی انجام شد.
روش کار: مطالعه حاضر یک مطالعه مروری است که داده‌های آن از مقالات بانک‌های اطلاعاتیGoogle scholar ، Medline (PubMed)، Cochran و Science direct جمع‌آوری شد. جستجوی جامع با استفاده از کلیدواژه‌های  Hepatitis Bو (infertility، male infertility، Female infertility، ART،Father to fetal transmission) انجام شد. با استفاده از قابلیت جستجوی پیشرفته، تمام مقالات چاپ شده طی 5 سال اخیر (2015-2010) که به زبان انگلیسی و دارای متن کامل بودند، انتخاب و پس از بررسی اولیه و جستجو بر اساس فهرست منابع، 43 مقاله وارد مطالعه شدند.
یافته ها: در مطالعه حاضر به جنبه‌های مختلفی از مسائل مرتبط با زوجین نابارور و بارور مبتلا به هپاتیت B که خواهان استفاده از فناوری کمک باروری هستند، پرداخته شد. نتایج بدست آمده نشان داد که اولاً غربالگری در زوجین مبتلا و افراد اهداءکننده سلول های جنسی، برای انجام اقدامات لازم و مشاوره مناسب بایستی الزامی شود ثانیاً ویروس هپاتیت در سلول‌های جنسی مخصوصاً به صورت آزاد و ادغام یافته با DNA می‌تواند اثرات منفی بر باروری و پیامد روش‌های کمک باروری داشته و می تواند از طریق سلول‌های جنسی به جنین انتقال یابد و در نهایت این که از شستشوی اسپرم و فناوری کمک باروری، می‌توان برای پیشگیری از انتقال ویروس استفاده نمود.
نتیجه گیری: یافته‌های پژوهش بیانگر اهمیت انجام غربالگری و استفاده از فناوری کمک باروری برای کاهش خطر انتقال عفونت هپاتیت B می‌باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Fertility Challenges and Considerations Related to Assisted Reproductive Technology in Couples with Hepatitis B: (Review Article)

نویسندگان [English]

  • Azita Fathnezhad kazemi 1
  • Nasibeh Sharifi 2
  • Maarefat Ghafari Novin 3
1 Instructor, Department of Midwifery, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2 PhD Student of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Tehran Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Professor, Department of Reproductive Endocrinology and Embryology, Infertility and Fertility Research Centre, Tehran Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده [English]

Introduction: Hepatitis B is the most common viral human health threat and is spread through sex and blood. Research has revealed negative effects of viral infections on human fertility while currently using assisted reproductive technology is increasing in persons affected by sexually transmitted diseases. The aim of the present study was a survey on fertility challenges, outcomes of assisted reproductive technology in couples affected by hepatitis B, and how the infection is transmitted through gametes.
Methods: Data for the present review article were collected from Google Scholar, Medline (Pubmed), Cochran, and ScienceDirect databases. Using hepatitis B and (infertility, male infertility, female infertility, ART, father to fetal transmission) keywords and advanced search, all full-text English articles published in the last five years (2010–2015) were chosen. After preliminary inspection and resource appendix search, 43 articles were selected.
Results: This article describes various aspects of problems associated with fertile and infertile couples with hepatitis B who are willing to use assisted reproductive technology. Results showed that firstly, screening the affected couples and gamete donors for taking the necessary actions and appropriate consultation must be mandatory, and secondly, the hepatitis virus in gametes in free form or integrated with the DNA can have negative effects on fertility and the outcome of assisted reproductive techniques, and can be transmitted via gametes to fetuses and finally, sperm washing and assisted reproductive technology can be used for prevention of virus transmission.
Conclusion: Research findings demonstrate the importance of screening and the use of assisted reproductive technology to reduce the risk of hepatitis B infection.

کلیدواژه‌ها [English]

  • Assisted reproductive technology
  • Gametes
  • Hepatitis B
  • Infertility
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