عنوان مقاله [English]
Introduction: Vulvovaginal candidiasis (VVC) is the most common vaginitis among women. The purpose of this study was comparing the efficacy of honey and clotrimazol 100 mg on vaginitis candidiasis. To evaluate the efficacy and tolerability of clotrimazol and honey or both, they were used for 7 days in the treatment of vaginitis candidiasis.
Methods: This double-blind clinical trial was conducted on 77 non-pregnant women aged 18 to 49 years with vaginitis candidiasis. Fifteen patients were in the honey group (Group 1), 30 in the honey and clotrimazole group (Group 2), and 32 in the clotrimazole group (Group 3). Participation in the study using vaginal clotrimazole and vaginal honey or both daily for 7 days. Baseline diagnosis consisted candidiasis culture together with clinical diagnosis and declaration of signs by the patients. Gynecological and microbiological tests confirmed the diagnosis, and patients were followed up for 7 and 21 days after the onset of treatment. Student t-test and chi-square statistical tests were used for data analysis.
Results: Alleviations occurred in symptoms and signs of vaginitis after treatment with honey and clotrimazole. The success rate for the treatment of vaginitis candidiasis was 100% in groups 1 and 2; seven and 30 days after intervention, the success was well observed in comparison with group 3, and the difference was significant (p<0.001). The medication was well tolerated.
Conclusion: Use of honey alone represents a novel and effective formulation for the treatment of vaginitis. Also, a combination of 100 mg of clotrimazole and 5ml of honey application was found to be effective in the treatment of the most common vaginitis.