بررسی مقایسه ای میزان هموسیستئین خون در زنان مبتلا و غیر مبتلا به پره اکلامپسی

نوع مقاله: اصیل پژوهشی

نویسندگان

1 کارشناس ارشد مامایی، دانشگاه آزاد اسلامی بجنورد، بجنورد، ایران.

2 دانشجوی دکترای علوم اعصاب، مرکز تحقیقات علوم اعصاب، دانشگاه علوم پزشکی کرمان، کرمان، ایران

3 کارشناس ارشد مامایی، دانشگاه آزاد اسلامی قوچان، قوچان، ایران

چکیده

مقدمه: فشار خون عارضه شایع دوران بارداری است که همراه با خونریزی و عفونت باعث مرگ و میر مادران می شود. پره اکلامپسی یک بیماری چند ارگانی با انقباضات عروقی وسیع است. مطالعات نشان داده اند که افزایش هموسیستئین خون با وقوع صدمه عروقی در پره اکلامپسی ارتباط دارد. مطالعه حاضر با هدف تعیین غلظت هموسیستئین در زنان با و بدون پره اکلامپسی انجام شد.
روش‌کار: این مطالعه مورد - شاهدی در سال 1387 بر روی 70 زن باردار تک قلو در سه ماهه سوم بارداری مراجعه کننده به بیمارستان های دانشگاه علوم پزشکی مشهد که دارای معیارهای ورود به مطالعه بودند، انجام شد. 35 نفر با تشخیص پره اکلامپسی در گروه مورد و 35 نفر با فشار خون طبیعی و عدم پروتئینوری در گروه شاهد قرار گرفتند و از نظر متغیرهای تأثیرگذار بر وقوع پره اکلامپسی تحت نظر قرار گرفتند. افراد دو گروه در مورد رژیم غذایی و مصرف مکمل ها همسان بودند. سپس اطلاعات افراد مورد مطالعه در پرسشنامه ها تکمیل شد میزان هموسیستئین در آنان اندازه گیری شد. داده ها با استفاده از نرم افزار آماری SPSS(نسخه 16) و آزمون های تی، کای دو، آنالیز واریانس دو طرفه مورد تجزیه تحلیل قرار گرفت. میزان p کمتر از 05/0 معنی دار در نظر گرفته شد.
یافته‌ها: دو گروه از نظر سن، توده بدنی قبل بارداری، سن بارداری، تعداد بارداری و زایمان و میزان هموگلوبین با هم همگن بودند. میزان هموسیستئین خون در زنان سالم (83/3 ± 22/8) و در زنان مبتلا به پره اکلامپسی (54/4 ± 16/9) تفاوت آماری معنی داری نداشت (3/0=p).
نتیجه‌گیری: میزان هموسیستئین خون در زنان مبتلا به پره اکلامپسی در مقایسه با زنان سالم بالاتر بود اما اختلاف آماری معنی داری وجود نداشت.

کلیدواژه‌ها


عنوان مقاله [English]

Comparative Investigation of Blood Hemocystein-Level in Women with and without Preeclampsia

نویسندگان [English]

  • Mitra Mahdavian 1
  • Hassan abbassian 2
  • Zahra Shojaeian 3
1 M.Sc. of Midwifery, Islamic Azad University of Bojnourd, Bojnourd, Iran.
2 Ph.D. student of Neuroscience, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
3 M.Sc. of Midwifery, Islamic Azad University of Ghuchan, Ghuchan, Iran.
چکیده [English]

Introduction: Hypertension is a common complication during pregnancy and its association with bleeding and infection causes maternal mortality and morbidity. Preeclampsia is a complex multi-organic disorder with extended vasospasm. According to some reports, there is a relationship between the increase of blood hemocystein-level and cardiovascular disorders in preeclampsia. Therefore, this research has been done with the aim of investigation of blood Hemocystein concentration in women with and without preeclampsia.
Methods: This cross-sectional case-control study was conducted among 70 singleton-pregnant women in third trimester who were admitted to the selected hospitals of medical university of Mashhad and had inclusion criteria. 35 women with preeclamptic signs were selected as case group and 35 women with normal blood pressure and no proteinuria were selected as control group. While diets and taken supplements of both groups were similar, effective variables on occurrence of preeclampsia were monitored. Demographic characteristics were filled in questionnaire form and homocysteine levels were measured. The gathered data were analyzed by SPSS software (version 16), T-test, chi square, two way ANOVA. P value less than 0.05 was considered statistically significant.
Results: Both groups were homogeneous in ages, pre-pregnancy BMI, gestational age, number of pregnancy, and hemoglobin level. Blood homocystein level was not statistically significant in both groups (9.16±4.54 in preeclamptic group vs. 8.22±3.38 in normal group)
Conclusion: Preeclamptic women had higher level of blood hemocystein in comparison with non-preeclamptic women but this difference was not significant.

کلیدواژه‌ها [English]

  • Gestational hypertension
  • Hemocystein
  • Preeclampsia
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