بررسی ارتباط نمایه و بارِ گلیسمی رژیم غذایی با سطح لیپیدهای سرم در زنان مبتلا به سندرم تخمدان پلی‌کیستیک

نوع مقاله: اصیل پژوهشی

نویسندگان

1 کارشناس ارشد علوم بهداشتی در تغذیه، دانشکده تغذیه و علوم غذایی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

2 استاد گروه تغذیه در جامعه، دانشکده تغذیه و علوم غذایی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

3 دانشیار گروه اپیدمیولوژی، دانشکده علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

10.22038/ijogi.2020.16290

چکیده

مقدمه: سندرم تخمدان پلی­کیستیک، یک اختلال اندوکرینی شایع در زنان است و مقاومت انسولینی از یافته­های بالینی این سندرم است که نقش مهمی در پیشرفت اختلالات لیپیدی ایفا می‌کند. نمایه و بارِ گلیسمی رژیم غذایی می­تواند روی لیپیدهای خون اثرگذار باشد. به دلیل محدودیت مطالعات انجام شده در این زمینه، مطالعه حاضر با هدف بررسی ارتباط نمایه و بارِ گلیسمی رژیمی و سطح لیپیدهای سرم در PCOS انجام گرفت.
روش‌کار: این مطالعه مورد- شاهدی در سال 1395 بر روی 45 زن مبتلا به PCOS و 45 زن سالم در بیمارستان زنان محب یاس تهران انجام شد. دریافت غذایی با استفاده از سه پرسشنامه یادآمد غذایی 24 ساعته ارزیابی و نمایه و بارِ گلیسمی با روش استاندارد محاسبه شد. پروفایل لیپیدی اندازه‌گیری و مقاومت انسولینی با استفاده از فرمول محاسبه گردید. اندازه‌گیری­های تن‌سنجی در تمام افراد انجام گرفت. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 16) و آزمون‌های تی مستقل و آزمون همبستگی انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: میانگین سطح سرمی کلسترول تام، مقاومت انسولین و میانگین نمایه گلیسمی در گروه بیمار به‌طور معناداری بیشتر از گروه سالم بود (05/0>p). بین بارِ گلیسمی با مقاومت به انسولین (388/0=r)، تری‌گلیسیرید (401/0=r) و HDL کلسترول (371/0- =r) در افراد بیمار ارتباط معناداری مشاهده شد (05/0>p). بین نمایه گلیسمی با شاخص­های بیوشیمیایی در افراد سالم و بیمار ارتباط معناداری مشاهده نشد (05/0<p). بارِ گلیسمی همبستگی مثبت و معناداری با مقاومت به انسولین (009/0=p) و تری‌گلیسیرید (006/0=p) نشان داد.
نتیجه‌گیری: اصلاح شیوه زندگی از جمله تغذیه صحیح و مدیریت کربوهیدرات دریافتی و کاهش بارِ گلیسمی رژیم غذایی ممکن است در پیشگیری یا کاهش عوارض بیماری از جمله اختلالات لیپیدی اثرگذار باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Association of dietary glycemic index and glycemic load with serum lipids level in women with polycystic ovary syndrome

نویسندگان [English]

  • Farzaneh Shahrdami 1
  • Beitolah Alipour 2
  • Elham Roohelhami 1
  • Bahram Rashidkhani 3
1 M.Sc. of Health Sciences in Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Professor, Department of Community Nutrition, School of Nutrition Sciences and Food Technology, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Associate professor, Department of Epidemiology, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tahran, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women and insulin resistance is one of the clinical features in this syndrome which plays an important role in improvement of lipid disorders. Dietary glycemic index and glycemic load can affect blood lipid disorders. Because of limited studies in this field, this study was performed with aim to evaluate the relationship between dietary glycemic index/glycemic load and serum lipids level in women with PCOS.
Methods: This case-control study was conducted on 45 PCOS women and 45 healthy controls in Moheb Yas Women hospital of Tehran in 2016. Dietary intake was assessed using three 24-h recall questionnaires, and glycemic index and glycemic load were calculated by standard methods. Lipid profile was measured and insulin resistance was calculated by the formula. Anthropometric measurements were conducted in all participants. Data were analyzed by SPSS software (version 16), and Independent T-test and correlation test. P< 0.05 was considered statistically significant.
Results: Mean of serum total cholesterol, insulin resistance and mean of glycemic index was significantly higher in the patients group than the control group (P<0.05). There was a significant relationship between glycemic load and insulin resistance, triglyceride and HDL-c in patients (r=0.388, r=0.401, r= -0.371, respectively (P<0.05). No significant relationship was found between glycemic index with biochemical markers in patients and controls (P>0.05).
Conclusion: Lifestyle modification like correct nutritional status and management of carbohydrate intake and reducing the dietary glycemic load may be effective in prevention or reducing the complications of disease such as lipid abnormalities.

کلیدواژه‌ها [English]

  • Glycemic Index
  • Glycemic load
  • Polycystic ovary syndrome
  • Serum lipids level
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