اثر هشت هفته تمرین ورزشی تناوبی بر شاخصهای استرس اکسیداتیو زنان با زایمان زودرس پس از جراحی گرافت عروق کرونری: کارآزمایی بالینی تصادفی شده

نوع مقاله: اصیل پژوهشی

نویسندگان

1 دانشیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

2 استادیار گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

10.22038/ijogi.2020.15991

چکیده

مقدمه: استرس اکسیداتیو، یکی از شاخص­هایی است که در طی زایمان زودرس و همچنین بیماری­های قلبی- عروقی تغییر می­یابد. عوامل متعددی بر این شاخص مؤثر هستند، از این رو مطالعه حاضر با هدف بررسی 8 هفته تمرین ورزشی تناوبیبر شاخص­های استرس اکسیداتیو زنان با زایمان زودرس پس از جراحی گرافت عروق کرونری (CABG) انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی در سال 1398 بر روی 21 زن با زایمان زودرس دارای سابقه جراحی گرافت عروق کرونر در دانشگاه علوم پزشکی تبریز انجام شد. پس از تخصیص تصادفی، از نمونه­ها خون گرفته شد و سپس گروه مداخله 24 جلسه تمرین ورزشی تناوبیرا انجام دادند و گروه کنترل زندگی عادی خود را می‌گذراندند. قبل و بعد از مداخله سطوح 8- هیدروکسی 2- دی اکسی گوانوزین سرمی و 8- هیدروکسی 2- دی اکسی گوانوزین ادراری اندازه‌گیری شد. تجزیه و تحلیل داده­ها با استفاده از نرم‌افزار آماری SPSS (نسخه 19) و آزمون­های آماری شاپیروویلک، تی دانشجویی و تی مستقل انجام شد. میزان p کمتر از 05/0 معنادار در نظر گرفته شد.
یافته‌ها: اثر برنامه تمرینات ورزشی تناوبیدر گروه مداخله موجب ایجاد اختلافات معنادار نسبت به قبل از ورزش در غلظت 8-هیدروکسی 2-دی اکسی گوانوزین سرمی (003/0=p) و ادراری (003/0=p) شد. همچنین اختلاف آماری بین‌گروهی متغیرهایی همچون وزن (048/0=p)، شاخص توده بدنی (004/0=p)، درصد چربی (002/0=p)، و 8-هیدروکسی 2-دیاکسی گوانوزین سرمی (001/0=p) و ادراری (001/0=p) در بین دو گروه مداخله و کنترل مشاهده شد.
نتیجه‌گیری: انجام ورزش­های تناوبی در زنان با سابقه زایمان زودرس که تحت عمل جراحی گرافت عروق کرونر قرار گرفته‌اند، می‌تواند موجب تغییر در شاخص استرس اکسیداتیو گردد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of eight weeks intermittent exercise training on oxidative stress indices in women with preterm labor after coronary artery bypass graft surgery (CABG): randomized clinical trial

نویسندگان [English]

  • Farnaz Sahhaf 1
  • Mehdi Nazari 2
  • Abbasali Dorosti 2
1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Assistant Professor, Department of Anesthesia, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
چکیده [English]

Introduction: Oxidative stress is one of the indicators that changes during preterm labor as well as cardiovascular diseases; several factors are effective on this index. Therefore, this study was performed with aim to evaluate eight weeks of intermittent exercise training on oxidative stress indices in women with preterm labor after coronary artery bypass graft surgery (CABG).
Methods: This clinical randomized trial study was performed on 21 women with preterm delivery and a history of coronary artery graft surgery at Tabriz University of Medical Sciences in 2019. After random allocation, blood sample was taken from the samples and then the intervention group performed 24 sessions of intermittent exercise and the control group had her normal life. Serum levels of 8-hydroxy-2-dioxan-guanosine and urinary 8-hydroxy-2-deoxy-guanosine were measured before and after the intervention. Data were analyzed by SPSS software (version 19) and Shapirovilk, Independent t and t-student tests. P< 0.05 was considered statistically significant.
Results: The exercise program in the intervention group caused a significant difference compared to pre-exercise in serum (P=0.003) and urinary (P=0.003) concentrations of 8-Hydroxy-2-dioxychuanosine. Intergroup difference of the variables such as weight (P=0.048), body mass index (P=0.004), fat percentage (P=0.002), and serum 8-hydroxy-2-dioxane guanosine (P=0.001) and urinary (P=0.001) were observed between the intervention and control groups.
Conclusion: Intermittent exercise in women with a history of preterm labor undergoing coronary artery bypass graft surgery could cause changes in oxidative stress index.

کلیدواژه‌ها [English]

  • Coronary Artery Graft
  • Intermittent training
  • Oxidative stress
  • Premature delivery
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