بررسی اثرات کپسول زنجبیل در درمان تهوع و استفراغ بیماران دریافت‌کننده سیس‌پلاتین تحت ماستکتومی: کارآزمایی بالینی تصادفی شده

نوع مقاله: اصیل پژوهشی

نویسندگان

1 استادیار گروه رادیوتراپی انکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

2 کارشناس ارشد آموزش پرستاری، کمیته تحقیقات سل و بیماری‌های ریوی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی تبریز، تبریز، ایران

10.22038/ijogi.2020.14949

چکیده

مقدمه: تهوع و استفراغ، یکی از شایع‌ترین و نامطلوب‌ترین عوارض داروی سیس‌پلاتین است. با توجه به اثرات زنجبیل در درمان و پیشگیری از تهوع و استفراغ، مطالعه حاضر با هدف بررسی اثرات کپسول زنجبیل در درمان تهوع و استفراغ بیماران دریافت‌کننده سیس‌پلاتین تحت ماستکتومی انجام شد.
روش‌کار: این مطالعه کارآزمایی بالینی تصادفی شده در سال 98-1397 بر روی 60 بیمار سرطانی در درمانگاه شیمی‌درمانی بیمارستان شهید مدنی تبریز انجام گرفت. گروه مداخله از 10 روز پس از شیمی‌درمانی و یک هفته قبل از ماستکتومی، روزانه 2 نوبت قرص 500 میلی‌گرمی زنجبیل را دریافت نمودند؛ گروه کنترل قرص پلاسبو استفاده نمود. قبل از مداخله و روز پس از ماستکتومی از ابزار سنجش تهوع و استفراغ رودز استفاده شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 21) و آزمون‌های شاپیروویلک و تی تست انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: در مقایسه درون‌گروهی، در گروه کنترل شدت تهوع پس از مداخله اختلاف آماری معنی‌داری نداشت (119/0=p)، درحالی‌که در گروه مداخله، اختلاف آماری معناداری پس از مداخله مشاهده شد (001/0=p)؛ همچنین در رابطه با شدت استفراغ در گروه کنترل تغییر معناداری مشاهده نشد (229/0=p)، در‌حالی‌که این نمره در گروه مداخله با کاهش معناداری همراه بود (004/0=p).
نتیجه‌گیری: کپسول زنجبیل در درمان تهوع و استفراغ زنانی که از رژیم دارویی سیس‌پلاتین استفاده نموده و قرار است تحت ماستکتومی قرار گیرند، مؤثر و مفید است.

کلیدواژه‌ها


عنوان مقاله [English]

Effects of ginger capsule on treatment of nausea and vomiting in patients receiving cisplatin undergoing mastectomy: a randomized clinical trial

نویسندگان [English]

  • Reza Eghdam-Zamiri 1
  • Mehdi Khanbabayi Gol 2
1 Assistant Professor, Department of Radiotherapy Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran .
2 M.Sc. in Nursing Education, Tuberculosis and Lung Disease Research Center, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده [English]

Introduction: Nausea and vomiting is one of the most common and undesirable side effects of cisplatin and due to the effects of ginger in the treatment and prevention of nausea and vomiting, this study was performed with aim to evaluate the effect of ginger capsule on treatment of nausea and vomiting in patients receiving cisplatin undergoing mastectomy.
Methods:This randomized clinical trial study was performed on 60 cancer patients in the chemotherapy clinic of Tabriz Shahid Madani Hospital in 2018-2019. The intervention group received ginger tablet 500 mg twice daily from 10th days after chemotherapy and one week before mastectomy. The control group received placebo tablet. Rhodes nausea and vomiting assessment tool was used before the intervention and the day after mastectomy. Data were analyzed by SPSS software (version 21) and Shapiro-Wilk and t-test. P<0.05 was considered statistically significant.
Results: The intra-group comparison showed the control group had no significant difference in terms of nausea severity after the intervention (p=0.119), whereas a significant difference was observed in the intervention group after the intervention (p=0.001). There was no significant change in vomiting severity in the control group (p=0.229), while this score was significantly decreased in the intervention group (p=0.004).
Conclusion: Ginger capsule is effective in treatment nausea and vomiting in women who have used cisplatin and are going to undergo mastectomy.

کلیدواژه‌ها [English]

  • Cisplatin
  • ginger
  • Mastectomy
  • Nausea
  • vomiting
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