بررسی ارتباط سطوح هورمونهای آندروژن، هیرسوتیسم و آکنه با افسردگی و اضطراب در زنان مبتلا به سندرم تخمدان پلی‌کیستیک

نوع مقاله : اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد بهداشت باروری و مامایی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

2 استادیار گروه بهداشت باروری و مامایی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

3 استاد گروه آمار زیستی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

چکیده

مقدمه: سطح کیفیت زندگی بیماران مبتلا به سندرم تخمدان پلی­کیستیک تحت تأثیر متغیرهای گسترده‌ای می­باشد. مطالعات مختلف نشان داده‌اند که این بیماران در معرض خطر بالای اختلال افسردگی و اضطراب قرار دارند. مهم­ترین علائم تخمدان پلی­کیستیک، هیرسوتیسم، آکنه و افزایش هورمون آندروژن است. مطالعه حاضر با هدف بررسی ارتباط سطوح هورمون‌های آندروژن، هیرسوتیسم و آکنه با افسردگی و اضطراب در زنان مبتلا به سندرم تخمدان پلی‌کیستیک انجام شد.
روش‌کار: این مطالعه مورد- شاهدی در سال 95-1394 بر روی 53 بیمار مبتلا به سندرم تخمدان پلی­کیستیک که بر اساس معیارهای تشخیصی روتردام انتخاب شدند و 50 زن سالم به‌عنوان گروه کنترل در بیمارستان آرش تهران انجام شد. ابزار گرد­آوری داده­ها، پرسشنامه­ای شامل مشخصات فردی و پرسشنامه افسردگی و اضطراب بک، مقیاس فریمن گالوی جهت بررسی درجه هیرسوتیسم، مقیاس جهانی درجه­بندی آکنه و ویژگی­های بالینی هیپرآندروژنیسم و نتایج آزمایشات (تستوسترون تام، تستوسترون آزاد، گلوبولین متصل به هورمون‌های جنسی) بود. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 21) و آزمون‌های تی­تست، کای­دو و ضریب همبستگی پیرسون انجام گرفت. میزان p کمتر از 05/0 معنی­دار در نظر گرفته شد.
یافته­ها: میانگین نمرات آکنه (02/0=p)، هیرسوتیسم (001/0>p)، توتال تستوسترون (008/0=p) و تستوسترون آزاد (01/0=p) در گروه بیمار به‌طور معنی­داری بالاتر از گروه کنترل بود. میانگین سطح SHBG در گروه مورد و گروه شاهد اختلاف آماری معنی­داری نداشت (3/0=p). میانگین نمرات افسردگی (001/0=p) و اضطراب (01/0=p) در گروه بیمار (82/9±35/20 و 44/10±35/17) به­طور معنی­داری بیش­تر از گروه کنترل (40/8±46/14 و 65/9±40/12) بود. بین نمرات کلی اضطراب و افسردگی با آکنه، هیرسوتیسم، توتال تستوسترون، تستوسترون آزاد و گلوبولین متصل به هورمون‌های جنسی ارتباط آماری معنی­داری مشاهده نشد (05/0<p).
نتیجه‌گیری: افزایش معنی‌دار در میزان نمرات اضطراب و افسردگی در گروه بیمار نسبت به گروه کنترل می‌تواند بیانگر خلق افسرده و مضطرب در مبتلایان به سندرم تخمدان پلی­کیستیک باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Relationship between levels of androgen hormones, hirsutism and acne with depression and anxiety in women with polycystic ovary syndrome

نویسندگان [English]

  • Saeideh Mehrabadi 1
  • Shahideh Jahanian Sadatmahalleh 2
  • Anoshirvan Kazemnejad 3
1 M.Sc. Student, Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2 Assistant Professor, Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
3 Professor, Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
چکیده [English]

Introduction: The quality of life in patients with polycystic ovary syndrome is affected by wide variables. Various studies have shown that these patients are at high risk of depression and anxiety. The most important symptoms of polycystic ovary syndrome include hirsutism, acne, and increased androgen hormones. This study was performed with aim to evaluate the relationship between levels of androgen hormones, hirsutism, and acne with depression and anxiety in women with polycystic ovary syndrome.
Methods: This case-control study was performed on 53 patients with polycystic ovary syndrome selected by Rotterdam criteria, and 50 healthy women as control group in Tehran Arash Hospital in 2015-2016. The tools of data collection were questionnaire of demographic information, Beck Depression and Anxiety questionnaire, Ferriman - Gallwey Score to assess the degree of hirsutism, Global Acne Grading System, clinical features of hyperandrogenism and laboratory tests’ results (Total testosterone, free testosterone, sex hormone binding globulin). Data were analyzed by SPSS software (version 21) and T-test, Chi-square, and Pearson Correlation Coefficient. P<0.05 was considered statistically significant.
Results:Mean scores of acne (p=0.02), hirsutism (p<0.001), total testosterone (p=0.008), and free testosterone (p=0.01) were meaningfully higher in patient group than control group. Mean Sex Hormone Binding Globulin level was not significant different in case and control groups (p=0.3). Mean scores of depression (p=0.001) and anxiety (p=0.01) in patient group (20.35±9.82 and 17.35±10.44) were significantly higher than control group (14.46±8.40 and 12.40±9.65). No significant relationship was found between total scores of acne, hirsutism, total testosterone, free testosterone and sex hormone binding globulin with depression and anxiety (p>0.05).
Conclusion: Significant increase in the scores of anxiety and depression in patient group compared to control group can be indicative of depressed and anxious mood in patients with polycystic ovary syndrome.

کلیدواژه‌ها [English]

  • Androgen
  • Anxiety
  • Depression
  • Polycystic ovary syndrome

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مجله زنان، مامایی و نازایی ایران
دوره 22، شماره 5
مرداد 1398
صفحه 61-70

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