بررسی ارتباط دیابت بارداری با سرطان آندومتر

نوع مقاله: اصیل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

2 مربی گروه مامایی، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 استادیار گروه مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

4 استادیار گروه رادیوتراپی و انکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

5 استادیار گروه آمار حیاتی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

چکیده

مقدمه: سرطان آندومتر، شایع‌ترین سرطان دستگاه تناسلی زنان در سراسر جهان محسوب می‌شود. میزان سرطان آندومتر در ایران رو به گسترش است. عوامل مختلفی بر بروز سرطان آندومتر مؤثر است. نقش دیابت بارداری در این عوامل نامشخص می‌باشد، لذا مطالعه حاضر با هدف مقایسه سابقه دیابت بارداری در زنان مبتلا و غیرمبتلا به سرطان آندومتر انجام شد.
روش‌کار: این پژوهش تحلیلی گذشته‌نگر بر روی 360 زن در سال 1396 مراجعه‌کننده به بیمارستان‌های تحت پوشش دانشگاه شهید بهشتی شهر تهران انجام گرفت. جمع‌آوری اطلاعات از طریق مصاحبه و تکمیل پرسشنامه‌های مشخصات جمعیت‌شناختی، باروری، سوابق پزشکی و اطلاعات مربوط به سرطان آندومتر بود. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS (نسخه 21) و آزمون‌های تی مستقل، کای دو، نسبت شانس و رگرسیون لوجستیک انجام گرفت. میزانp کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: در این مطالعه در مجموع 29 نفر (8%) سابقه دیابت بارداری داشتند که 17 نفر (2/14%) در گروه مورد و 12 نفر (5%) در گروه کنترل بودند. بین دو گروه مبتلا و غیرمبتلا به سرطان آندومتر از نظر دیابت بارداری تفاوت آماری معنی‌داری وجود داشت (05/0>p).
نتیجه‌گیری: وجود سابقه‌ دیابت بارداری باعث افزایش خطر سرطان آندومتر می‌گردد؛ بنابراین می‌تواند جهت پیشگیری اولیه و تشخیص زودرس سرطان آندومتر به‌کار رود.

کلیدواژه‌ها


عنوان مقاله [English]

Relationship between gestational diabetes and endometrial cancer

نویسندگان [English]

  • Zohreh Yeganeh 1
  • Zohre Sheikhan 2
  • Nourossadat Kariman 3
  • Parasto Hajian 4
  • Malihe Nasiri 5
1 M.Sc. student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Instructor, Department of Midwifery, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant Professor, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 Assistant Professor, Department of Radiotherapy and Oncology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5 Assistant Professor, Department of Biostatics, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Endometrial cancer is the most common gynecological malignancy in women worldwide. The rate of endometrial cancer is increasing in Iran. Various factors affect the incidence of endometrial cancer. The role of gestational diabetes in these factors is unclear. Therefore, this study was performed with aim to compare the history of gestational diabetes in women with endometrial cancer and healthy women.
Methods: This retrospective analytical study was performed on 360 women referring to hospitals of Shahid Beheshti University of Medical Sciences in Tehran in 2017. Data was collected by interview and completing the questionnaire of demographic, fertility characteristics, medical records and endometrial cancer information. Data were analyzed by SPSS software (version 21) and Chi-square, independent t-test, Odds ratio and Logistic Regression. P<0.05 was considered statistically significant.
Results: In this study, 29 women (8%) had history of gestational diabetes that 17 women (14.2%) were in case group and 12 (5%) in control group. There was significant difference between two groups of women with endometrial cancer and healthy women in terms of gestational diabetes (p<0.05).
Conclusion: History of gestational diabetes increases the risk of endometrial cancer; therefore it can be used for primary prevention and early diagnosis of endometrial cancer.

کلیدواژه‌ها [English]

  • Endometrial Cancer
  • Gestational diabetes
  • Iran
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