تأثیر تمرینات با مقاومت کل بدن (TRX) و مصرف مکمل امگا-3 بر سطح سرمی ویسفاتین و مقاومت به انسولین مبتلایان به سندرم تخمدان پلی‌کیستیک

نوع مقاله: اصیل پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد اصفهان (خوراسگان)، اصفهان، ایران.

2 دانشیار گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد اصفهان (خوراسگان)، اصفهان، ایران.

3 استادیار گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد اصفهان (خوراسگان)، اصفهان، ایران.

چکیده

مقدمه: سندرم تخمدان پلی‌کیستیک، از شایع‌ترین بیماری‌های اندوکرینی با عوارض هایپرانسولینمی در زنان می‌باشد. ناباروری با شیوع حدود 15%، یکی از مشکلات عمده جامعه می‌باشد، لذا مطالعه حاضر با هدف بررسی تأثیر 8 هفته TRX و مصرف مکمل امگا-3 بر سطح سرمی ویسفاتین و مقاومت به انسولین در زنان مبتلا به سندرم تخمدان پلی‌کیستیک انجام شد.
روش‌‌کار: اینمطالعه کارآزمایی بالینی در سال 1396 بر روی 28 بیمار مبتلا به سندرم تخمدان پلی‌کیستیک در شهر اصفهان انجام شد. شرکت‌کنندگان به‌طور تصادفی به چهار گروه تمرین TRX، مصرف مکمل امگا-3، ترکیب تمرین- مکمل و کنترل تقسیم شدند. گروه مکمل و ترکیبی بسته‌های حاوی 56 کپسول یک گرمی مکمل امگا-3 (360 میلی‌گرم EPA و 280 میلی‌گرم DHA) دریافت کردند. گروه تمرین و ترکیبی تحت تأثیر یک برنامه تمرینی TRX شامل 10 دقیقه گرم کردن، 45 دقیقه تمرین TRX و 10 دقیقه سرد کردن قرار گرفتند. گروه کنترل نیز بدون هیچ مداخله‌ای فقط پیگیری شدند. به‌منظور تعیین سطوح سرمی ویسفاتین، گلوکز ناشتا، انسولین و مقاومت به انسولین، قبل و پس از 8 هفته مداخله، نمونه خونی گرفته شد. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS‌ (نسخه 21) و آزمون تی همبسته و تحلیل واریانس انجام شد. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: پس از 8 هفته مداخله کاهش وزن در گروه TRX به‌طور معناداری بیشتر از گروه مکمل و کنترل بود (05/0>p). اختلاف میانگین سطح قندخون ناشتا قبل و بعد از مداخله در گروه تمرین، مکمل و کنترل معنی‌دار بود (05/0>p). همچنین اختلاف میانگین انسولین قبل و بعد از مداخله در گروه تمرین، مکمل و ترکیبی معنی‌دار بود (05/0>p). اختلاف میانگین مقاومت به انسولین قبل و بعد از مداخله در هر چهار گروه معنی‌دار بود (05/0>p). تغییرات سطح سرمی ویسفاتین قبل و بعد از مداخله در گروه تمرین، مکمل و ترکیبی معنی‌دار بود (05/0>p).
نتیجه‌گیری: هشت هفته تمرین TRX و مصرف مکمل امگا-3 به واسطه کاهش وزن و مقاومت به انسولین می‌تواند در کنترل و بهبود عوارض ناشی از بیماری بیماران سندرم تخمدان پلی‌کیستیک در زنان مؤثر باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of eight weeks of supplementation of omega-3 supplementation and TRX training on visfatin and insulin resistance in women with polycystic ovary syndrome

نویسندگان [English]

  • Fariba Khoshkam 1
  • Farzaneh Taghian 2
  • Khosro Jalali Dehkordi 3
1 M.Sc. of Sport Physiology, School of Physical Education and Sport Sciences, Isfahan (Khorasgan) branch, Islamic Azad University, Isfahan, Iran.
2 Associate professor, Department of Sport Physiology School of Physical Education and Sport Sciences, Isfahan (Khorasgan) branch, Islamic Azad University, Isfahan, Iran.
3 Assistant professor, Department of Sport Physiology, School of Physical Education and Sport Sciences, Isfahan (Khorasgan) branch, Islamic Azad University, Isfahan, Iran.
چکیده [English]

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases with hyperinsulinemia in women. Infertility with prevalence of 15% is one of the major problems in the society. Therefore, this study was performed with aim to evaluate the effect of 8 weeks of TRX and omega-3 supplementation on serum visfatin levels and insulin resistance in women with PCOS.
Methods: This clinical trial study was performed in 2017 on 28 patients with polycystic ovary syndrome in Isfahan. Participants were randomly divided into four groups: TRX training, omega-3 supplementation, exercise-supplementation, and control. The supplement and combination groups received 56 capsules of omega-3 supplement 1 gr (360 mg of EPA and 280 mg of DHA). The exercise and combination groups received an exercise program TRX including 10 minutes warm-up, 45 minutes TRX training and 10 minutes of cool-down. The control group was only followed up without any intervention. Blood samples were taken before and after 8 weeks of intervention to determine the serum levels of visfatin, fasting glucose, insulin and insulin resistance. Data analysis was performed using SPSS software (version 21) and by correlated t-test and variance analysis. P < 0.05 was considered statistically significant.
Results: After 8 weeks of intervention, weight loss in the TRX group was significantly higher than that of the supplement and control groups (p <0.05). The difference in mean fasting blood glucose level before and after the intervention was significant in the exercise, supplementation and control groups (p <0.05). Also, the difference in mean of insulin before and after the intervention was significant in the exercise, supplementation and combination groups (p <0.05). The difference in mean of insulin resistance before and after the intervention was significant in all 4 groups (p <0.05). Changes in serum visfatin levels were significant before and after the intervention in the exercise, supplementation and combination groups (p <0.05).
Conclusion: Eight weeks of TRX training and the use of omega-3 supplementation due to weight loss and insulin resistance can be effective in controlling and improving the complications of polycystic ovary syndrome in women.

کلیدواژه‌ها [English]

  • insulin resistance
  • Omega-3
  • Polycystic ovary syndrome
  • TRX
  • Visfatin
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