بررسی تأثیر زنجبیل بر دیسمنوره اولیه: مروری سیستماتیک بر کارآزماییهای بالینی و مطالعات نیمه‌تجربی انجام شده در جهان

نوع مقاله: مروری

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

2 دانشجوی دکترای بهداشت باروری، کمیته تحقیقات دانشجویی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

3 استادیار گروه مامایی و بهداشت باروری، مرکز تحقیقات مامایی و بهداشت باروری، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی شهید بهشتی تهران، تهران، ایران.

چکیده

مقدمه: دیسمنوره، اختلال ژنیکولوژیک شایعی می­باشد که در هر سیکل قاعدگی، باعث بروز مشکلات رفتاری و اختلال در روند زندگی روزمره یک زن می­گردد. زنجبیل در درمان دیسمنوره ایفای نقش می­نماید، از این رو مطالعه مروری حاضر با هدف جمع‌آوری و بررسی کارآزمایی­های بالینی در رابطه با تأثیر زنجبیل خوراکی و موضعی بر دیسمنوره انجام شد.
روش‌کار: در این مطالعه مروری، کارآزمایی­های بالینی و مطالعات نیمه‌تجربی تا دسامبر 2017 به زبان فارسی و انگلیسی در پایگاه­های فارسی IranMedex، Magiran، IranDoct، IRCT و پایگاه­های انگلیسی PubMed، Scopus،Science direct ، Embase و Cochrane و با کلید واژه‌های فارسی دیسمنوره، قاعدگی دردناک، زنجبیل و انگلیسیDysmenorrhea ، Menstrual pain، Menstrual cramp، Painful menstruation، Zingiber، Ginger، Shokyo، Gingiber officinale و Zingier بدون اعمال محدودیت زمانی مورد بررسی قرار گرفتند و مقالات دارای معیار ورود، وارد مطالعه شده و مورد آنالیز کیفی قرار گرفتند.
یافته‌ها: پس از بررسی 2101 مقاله، 12 کارآزمایی بالینی که بر اساس معیار جداد نمره 3 و بالاتر و 3 مطالعه نیمه تجربی بر اساس معیار EPHPP با امتیاز 00/3-51/1 مورد بررسی قرار گرفتند. در اکثر مقالات به خاصیت ضدالتهابی و مهار سیکلواکسیژناز و به دنبال آن کاهش لوکوترین و پروستاگلاندین در هر دو فرم خوراکی و موضعی زنجبیل اشاره شده بود که در تسکین درد دیسمنوره مؤثر بودند. به دلیل ناهمگونی مطالعات، امکان انجام متاآنالیز وجود نداشت.
نتیجه‌گیری: با توجه به نتایج به‌دست آمده، شواهد قابل اعتباری مبنی بر تأثیر مثبت زنجبیل خوراکی و موضعی بر کاهش درد و التهاب به‌خصوص در سه روز اول قاعدگی وجود دارد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of Ginger on primary Dysmenorrhea: A systematic review of clinical trials and Quasi- Experimental studies in the world

نویسندگان [English]

  • Shabnam Mozafari 1
  • Marzieh Saei Ghare Naz 2
  • Giti Ozgoli 3
1 M.Sc. Student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Ph.D. student in Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Assistant professor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده [English]

Introduction: Dysmenorrhea is a common gynecological disorder that causes behavioral problems and impairment in daily life of a woman in each menstruation cycle. Ginger plays an effective role in treatment of dysmenorrhea. Therefore, this review article was performed with aim to collect and review the clinical trials about effects of oral and topical ginger on dysmenorrhea.
Methods: In this review study, clinical trials and Quasi – Experimental studies up to Dec 2017 in Persian and English languages in Persian databases of IranMedex, Magiran, IranDoct, IRCT and English dataases of PubMed, Scopus, Science direct, Embase, Cochrane with  Persian and English keywords such as Dysmenorrhea, Menstrual pain, Menstrual cramps, Painful menstruation, Zingiber, Ginger, Shokyo, Gingiber officinale, and Zingier were reviewed without any time limitation and the articles with inclusion criteria entered into the study and were evaluated by qualitative analysis.
Results: After reviewing 2101 articles, 12 clinical trials which based on Jadad score obtained ≥3 and 3 Quasi- experimental studies which based on EPHPP tool obtained 1.51-3.00 were evaluated. Most of the articles referred to the anti-inflammatory properties and inhibition of cyclooxygenase, followed by the reduction of gastrointestinal leukotriene and prostaglandin in relieving painful dysmenorrhea in both forms of oral and typical. There was not possible to do meta-analysis due to the heterogeneity of the studies.
Conclusion: According to the results, there is credible evidence on the positive effect of oral and topical ginger on reducing pain and inflammation, especially in the first three days of menstruation.

کلیدواژه‌ها [English]

  • Clinical trial
  • Dysmenorrhea
  • ginger
  • Herbal Medicine
  • Painful Menstruation
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