مروری بر راهکارهای حفظ باروری بیماران سرطانی در درمان‌های رایج

نوع مقاله: مروری

نویسندگان

1 دکترای تخصصی ژنتیک پزشکی، مرکز تحقیقات علوم سلولی و مولکولی، پژوهشکده علوم پایه سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران.

2 دکترای تخصصی فیزیولوژی پزشکی، گروه علوم پایه، دانشگاه فرهنگیان، تهران، ایران.

چکیده

مقدمه: سالانه افراد زیادی در جهان به انواع سرطان‌ها مبتلا می‌شوند. امروزه با مراقبت‌های ویژه و روش‌های درمانی متنوع چند گزینه‌ای و ترکیبی، طول عمر در بسیاری از افراد سرطانی افزایش یافته است. افزایش پتانسیل بقاء با درمان سرطان، اغلب با اثرات جانبی از جمله تأثیر بر باروری و کیفیت آن در بیماران جوان همراه است. اقدامات ضروری جهت حفظ پتانسیل باروری در طی درمان سرطان از اهمیت ویژه‌ای برخوردار است. مطالعه مروری حاضر با هدف بررسی جدیدترین روش‌های حفظ باروری در حین درمان‌های سرطان انجام شد.
روش‌کار: در این مطالعه مروری برای جستجوی مقالات از سه پایگاه اطلاعاتی Google Scholar، Scopus و PubMed و کلید واژه­های infertility cancer، fertility cancer، infertility chemotherapy و fertility chemotherapy ‎استفاده شد. مقالاتی که هدف نگارش این مقاله را در بر نداشتند، از مراحل مطالعه حذف گردید.
یافته‎ها: راهکارهای متنوعی جهت حفظ باروری بیماران سرطانی پس از درمان‌های متداول وجود دارد. انجماد و تهیه بانک اسپرم، تخمک و جنین، انجماد بافت بیضه و تخمدان، استفاده از عوامل حفظ باروری و انواع سلول‌های بنیادی، از مهم‌ترین روش‌های استاندارد حفظ باروری در بیماران سرطانی تحت درمان هستند.
نتیجه‎گیری: امروزه قبل از هر اقدام درمانی سرطان، لازم است بیماران مشاوره مناسب مرتبط با خطرات باروری و حمایت‌های مرتبط جهت گزینه­های حفظ باروری را دریافت کنند.

کلیدواژه‌ها


عنوان مقاله [English]

A review of fertility preservation strategies for cancer patients in common treatments

نویسندگان [English]

  • Sorayya Ghasemi 1
  • Firoozeh Alavian 2
1 PhD in Medical Genetic, Cellular and Molecular Research Center, Health Basic Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 PhD in Medical Physiology, Department of Basic Sciences, Farhangian University, Tehran, Iran.
چکیده [English]

Introduction: Annually, many people in the world are affected with a variety of cancers. Today, with variety of intensive care and multidisciplinary and combined treatments, longevity increases in many cancer patients. Increasing the survival potential with cancer treatment is often associated with side effects including effects on fertility and its quality in young patients. Essential measures to maintain the fertility potential during cancer treatment is of particular importance. This review article was performed with aim to investigate the newest methods for preserving fertility during cancer treatments.
Methods: In this review article, to search the articles, three databases of Google Scholar, Scopus and PubMed and the keywords of "infertility cancer", "fertility cancer"، "infertility chemotherapy" and "fertility chemotherapy" were used. The articles that did not include the purpose of this article were removed from the study process.
Results: There are various ways to maintain fertility in cancer patients after the common treatments. Freezing and preparation of sperm, egg and embryos bank, testis and ovarian tissue freezing, the use of fertoprotective agents and the stem cell types are the most important standard methods for preserving fertility in cancer patients undergoing treatment.
Conclusion: Today, before any cancer treatments, it is necessary for patients to receive appropriate counseling related to fertility risks and related support for fertility preservation options before any cancer treatment.

کلیدواژه‌ها [English]

  • Cancer
  • Fertility
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