نقش هورمون ادیپونکتین در باروری و ناباروری: مروری سیستماتیک

نوع مقاله: مروری

نویسندگان

1 دانشجوی کارشناسی ارشد مامایی، دانشکده پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

2 استادیار گروه بهداشت باروری و مامایی، دانشکده پزشکی، دانشگاه تربیت مدرس، تهران، ایران.

چکیده

مقدمه: ادیپونکتین، یکی از هورمون‌های خانواده ادیپوکین است که از سلول‌های بافت چربی آزاد می‌شود و نقش‌های بیولوژیک فراوانی دارد. بر اساس مطالعات گذشته، سطح این هورمون در افراد چاق کاهش می‌یابد. مطالعات مختلفی در مورد ارتباط ادیپونکتین و بیماری‌های زنان انجام شده است، ولی تاکنون مطالعه‌ای مروری در رابطه با نقش هورمون ادیپونکتین در باروری و ناباروری انجام نشده است. مطالعه مروری حاضر با هدف بررسی نقش هورمون ادیپونکتین در باروری و ناباروری انجام شد.
روش‌کار: در این مطالعه مروری 18 مقاله با جستجو در بانک­های اطلاعاتی Science Direct، Iran Medex و Pubmed با کلید واژه­های ادیپونکتین، باروری، ناباروری، تخمک‌گذاری از بازه زمانی 1996 تا 2018 مورد بررسی قرار گرفتند. مطالعات دسته‌بندی شدند. میزان p کمتر از 05/0 معنی‌دار در نظر گرفته شد.
یافته‌ها: ادیپونکتین یکی از هورمون‌های مؤثر در سیستم باروری است. اختلالات تخمک‌گذاری (PCO، آمنوره هیپوتالاموسی)، سندرم متابولیک، مقاومت به انسولین و نازایی با کاهش ادیپونکتین همراه است. درمان‌های نازایی (تحریک تخمک‌گذاری، IVF، ICSI و ...) با افزایش غلظت ادیپونکتین همراه است. موفقیت درمان در افرادی که ادیپونکتین بالاتری دارند، بیشتر است.
نتیجه‌گیری: با توجه به اثرات مثبت ادیپونکتین و نقش اساسی آن در باروری و ناباروری، می‌توان از اندازه‌گیری آن در مدیریت و پیگیری باروری و ناباروری بهره‌مند شد، لذا توجه و تحقیق بیشتر نسبت به ادیپونکتین لازم است.

کلیدواژه‌ها


عنوان مقاله [English]

Role of Adiponectin Hormone in Fertility and Sterility: A Systematic Review

نویسندگان [English]

  • Fattaneh Pahlavan 1
  • Fatemeh Tork tatari 1
  • Saeideh Fazeli 1
  • Fatemeh Razavinia 1
  • Najmeh Tehranian 2
1 M.Sc. Student of Midwifery, School of Medicine, Tarbiat Modares University, Tehran, Iran.
2 Assistant Professor, Department of Reproductive Health and Midwifery, School of Medicine, Tarbiat Modares University, Tehran, Iran.
چکیده [English]

Introduction: Adiponectin is a hormone from adipokine family, which releases from adipose tissue cells and has many biological roles. According to the literature, the level of this hormone reduces in obese individuals. Several studies have investigated the relationship between adiponectin and gynecological diseases. However, no study reviewed the role of adiponectin hormone in fertility and sterility. Therefore, the aim of this study was to review the literature regarding adiponectin hormone role in fertility and sterility.
Methods: This study reviewed 18 articles which were searched in the reputable online databases, including PubMed, Science Direct, and Iran Medex. The searches were performed using keywords, such asadiponectin, fertility, sterility, and ovulation among the papers published during 1996-2018. We classified the studies and considered P < 0.05 as significant.
Results: Adiponectin is one of the hormones that affect the reproductive system.Ovulation disorders (e.g., PCO and hypothalamic amenorrhea), metabolic syndrome, insulin resistance, and infertility are associated with reduced adiponectin level. On the other hand, treatments for infertility, including ovulation induction, IVF, and ICSI are accompanied by increase in adiponectin level. Therapy is more likely to be successful in subjects with higher adiponectin.
Conclusion: Regarding the positive effects of adiponectin and its basic role in fertility and sterility, it is possible to measure and evaluate this hormone for management and follow-up of fertility and sterility. Consequently, further attention and research about this hormone seems to be necessary.

کلیدواژه‌ها [English]

  • Adiponectin
  • ART
  • Fertility
  • Ovulation
  • Sterility
  1. Faghani Aghoozi M, Tehranian N. Effect of Leptin on weight gain in pregnant women: a systematic review. Iran J Obstet Gynecol Infertil 2015; 17(132):16-27. (Persian).
  2. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPoseMost abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221(2):286-9.
  3. Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998; 8(6):335-8.
  4. Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003; 148(3):293-300.
  5. Chen J, Tan B, Karteris E, Zervou S, Digby J, Hillhouse E, et al. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia 2006; 49(6):1292-302.
  6. Ukkola O, Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities? J Mol Med 2002; 80(11):696-702.
  7. Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, et al. Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab 2014; 20(2):368-75.
  8. Renaldi O, Pramono B, Sinorita H, Purnomo LB, Asdie RH, Asdie AH. Hypoadiponectinemia: a risk factor for metabolic syndrome. Acta Med Indones 2009; 41(1):20-4.
  9. Coppola A, Marfella R, Coppola L, Tagliamonte E, Fontana D, Liguori E, et al. Effect of weight loss on coronary circulation and adiponectin levels in obese women. Int J Cardiol 2009; 134(3):414-6.
  10. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423(6941):762-9.
  11. Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 2004; 101(28):10308-13.
  12. Richards JS, Liu Z, Kawai T, Tabata K, Watanabe H, Suresh D, et al. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril 2012; 98(2):471-9.e1.
  13. Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD. Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 2006; 147(11):5178-86.
  14. Chabrolle C, Tosca L, Ramé C, Lecomte P, Royère D, Dupont J. Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells. Fertil Steril 2009; 92(6):1988-96.
  15. Dos Santos E, Serazin V, Morvan C, Torre A, Wainer R, de Mazancourt P, et al. Adiponectin and leptin systems in human endometrium during window of implantation. Fertil Steril 2012; 97(3):771-8.e1.
  16. Schindler M, Fischer S, Thieme R, Gürke J, Haucke E, Knelangen JM, et al. Hormonal and metabolic adaptation of preimplantation embryos to the uterine environment: A key mechanism for embryonic survival in a diabetic pregnancy. Exp Clin Endocrinol Diabetes 2014; 122(3):OP4_15.
  17. Tsatsanis C, Dermitzaki E, Avgoustinaki P, Malliaraki N, Mytaras V, Margioris AN. The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis. Hormones (Athens) 2015; 14(4):549-62.
  18. Fuglsang J, Skjærbæk C, Frystyk J, Flyvbjerg A, Ovesen P. A longitudinal study of serum adiponectin during normal pregnancy. BJOG 2006; 113(1):110-3.
  19. Mazaki-Tovi S, Kanety H, Pariente C, Hemi R, Wiser A, Schiff E, et al. Maternal serum adiponectin levels during human pregnancy. J Perinatol 2007; 27(2):77-81.
  20. Catalano P, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, et al. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia 2006; 49(7):1677-85.
  21. Chan TF, Yuan SS, Chen HS, Guu CF, Wu LC, Yeh YT, et al. Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights. Acta Obstet Gynecol Scand 2004; 83(2):165-9.
  22. Kajantie E, Hytinantti T, Hovi P, Andersson S. Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term. J Clin Endocrinol Metab 2004; 89(8):4031-6.
  23. Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, Drevon CA. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Am J Physiol Endocrinol Metab 2006; 290(2):E326-33.
  24. Dafopoulos K, Sourlas D, Kallitsaris A, Pournaras S, Messinis IE. Blood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle. Fertil Steril 2009; 92(4):1389-94.
  25. Olszanecka-Glinianowicz M, Kuglin D, Dąbkowska-Huć A, Skałba P. Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2011; 154(1):51-6.
  26. Panidis D, Kourtis A, Farmakiotis D, Mouslech T, Rousso D, Koliakos G. Serum adiponectin levels in women with polycystic ovary syndrome. Hum Reprod 2003; 18(9):1790-6.
  27. Orio F Jr, Palomba S, Cascella T, Milan G, Mioni R, Pagano C, et al. Adiponectin levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88(6):2619-23.
  28. Toulis KA, Goulis DG, Farmakiotis D, Georgopoulos NA, Katsikis I, Tarlatzis BC, et al. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Hum Reprod Update 2009; 15(3):297-307.
  29. Comim FV, Hardy K, Franks S. Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome. PLoS One 2013; 8(11):e80416.
  30. Artimani T, Saidijam M, Aflatoonian R, Ashrafi M, Amiri I, Yavangi M, et al. Downregulation of adiponectin system in granulosa cells and low levels of HMW adiponectin in PCOS. J Assist Reprod Genet 2016; 33(1):101-10.
  31. Gulcelik NE, Aral Y, Serter R, Demir Y, Çulha C. Adiponectin is an independent determinant of insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol 2006; 22(9):511-5.
  32. Ko JK, Li HW, Lam KS, Tam S, Lee VC, Yeung TW, et al. Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome. Gynecol Endocrinol 2016; 32(5):390-4.
  33. Allaway HC, Southmayd EA, De Souza MJ. The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa. Horm Mol Biol Clin Investig 2016; 25(2):91-119.
  34. O'Donnell E, De Souza MJ. Increased serum adiponectin concentrations in amenorrheic physically active women are associated with impaired bone health but not with estrogen exposure. Bone 2011; 48(4):760-7.
  35. Lanfranco F, Zitzmann M, Simoni M, Nieschlag E. Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy. Clin Endocrinol 2004; 60(4):500-7.
  36. Kawwass JF, Summer R, Kallen CB. Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review. Mol Hum Reprod 2015; 21(8):617-32.
  37. Wassim Y, Dendana M, Jrah H. Genetic variants of adiponectin and risk of idiopathic recurrent miscarriage: impact of obesity. JES 2016; 2(6):1-4.
  38. Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, et al. Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinology 2006; 147(7):3203-10.
  39. Choi J. The role of inflammation and autoimmunity in first trimester spontaneous abortion [26G]. Obstet Gynecol 2016; 127:66S.
  40. Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E. Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity. Fertil Steril 2009; 91(5):1837-41.
  41. Liu YH, Tsai EM, Chen YL, Chen HS, Chen YC, Wu LC, et al. Serum adiponectin levels increase after human chorionic gonadotropin treatment during in vitro fertilization. Gynecol Obstet Invest 2006; 62(2):61-5.
  42. Liu YH, Tsai EM, Wu LC, Chen SY, Chang YH, Jong SB, et al. Higher basal adiponectin levels are associated with better ovarian response to gonadotropin stimulation during in vitro fertilization. Gynecol Obstet Invest 2005; 60(3):167-70.
  43. Chang HJ, Lee JH, Lee JR, Jee BC, Suh CS, Kim SH. Relationship between follicular fluid adipocytokines and the quality of the oocyte and corresponding embryo development from a single dominant follicle in in vitro fertilization/intracytoplasmic sperm injection cycles. Clin Exp Reprod Med 2014; 41(1):21-8.
  44. Yen M, Donma O, Yildizfer F, Ekmekci O, Asli Kuratas Kul Z, Esat Imal A, et al. Association of fetuin A, adiponectin, interleukin 10 and total antioxidant capacity with IVF outcomes. Iran J Reprod Med 2014; 12(11):747-54.
  45. Bersinger NA, Wunder DM. Adiponectin isoform distribution in serum and in follicular fluid of women undergoing treatment by ICSI. Acta Obstet Gynecol Scand 2010; 89(6):782-8.
  46. Bersinger NA, Wunder DM, Birkhaeuser MH. Adiponectin as a marker of success in IVF treatment. Hum Reprod 2006; 21:198-99.
  47. Kleiblova P, Springer D, Haluzik M. The influence of hormonal changes during menstrual cycle on serum adiponectin concentrations in healthy women. Physiol Res 2006; 55(6):661-6.