بررسی اثر فرمهای فرموله شده جدید کورکومین بر مهار رشد تومور در سرطان پستان: مقاله مروری

نوع مقاله: مروری

نویسندگان

1 دانشجوی دکتری فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

2 استادیار گروه ژنتیک، مرکز تحقیقات سرطان و گروه فناوری‌های نوین، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

3 استاد گروه زنان و مامایی، مرکز تحقیقات سلامت زنان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

4 دانشیار گروه انکولوژی،‌ مرکز تحقیقات سرطان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

5 استادیار گروه زنان و مامایی، مرکز تحقیقات سلامت زنان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

6 استادیار گروه پرتودرمانی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

7 استاد گروه فیزیولوژی، مرکز تحقیقات التهاب نوروژنیک و گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

8 استادیار گروه بیوشیمی بالینی، مرکز تحقیقات سندرم متابولیک و گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.

چکیده

مقدمه: سرطان پستان، شایع‌ترین بیماری بدخیم در بین زنان و دومین علت مرگ‌و‌میر ناشی از سرطان، پس از سرطان ریه در زنان می­باشد. کورکومین، یک ­ترکیب گیاهی است که اثرات ضد سرطانی آن در مطالعات پیش بالینی و بالینی نشان داده شده است. اثرات ضد سرطانی کورکومین شامل مهار شکل‌گیری سلول سرطانی، مهار آنژیوژنز و مهار رشد تومور می­باشد. به دلیل جذب پایین کورکومین در روده، حلالیت پایین در آب و متابولیسم سریع و دفع زیاد، فراهمی زیستی کورکومین پایین می­باشد، بنابراین استفاده از کورکومین فرموله می­تواند باعث افزایش فراهمی کورکومین گردد. مقاله مروری حاضر با هدف بررسی اثرات کورکومین و ­ترکیبات نانو فرموله آن در پیشگیری و درمان سرطان پستان انجام شد.
روش‌کار: در این مطالعه مروری مقالات انگلیسی و فارسی مناسب و مرتبط از پایگاه­های الکترونیکی Pubmed، Scopus ،Google Scholar  و Magiran تا پایان سال ۲۰۱۶ با استفاده از کلید واژه­های Curcumin، Cancer، Breast و Nanoform Clinical Study و در مقالات فارسی با کلمات سرطان، پستان، زردچوبه، مطالعات بالینی و اشکال نانو بررسی و در مجموع 45 مقاله گردآوری و بررسی شدند.
یافته‌ها: نتایج مطالعات مختلف نشان داد که استفاده از کورکومین فرموله شده از یک سو باعث افزایش جذب و فراهمی زیستی آن شده و از سوی دیگر باعث افزایش اثربخشی آن بر سلول‌های سرطانی از جمله سرطان پستان می‌شود که این نتایج می­تواند نشان دهنده اثرات مفید ­ترکیبات نانوفرموله کورکومین در پیشگیری و درمان سرطان پستان باشد.
نتیجه‌گیری: به دلیل فراهمی زیستی بالاتر­ ترکیبات فرموله شده کورکومین در مقایسه با فرم آزاد کورکومین و با توجه به سمیت پایین این داروی گیاهی، می‌توان از آن در کنار سایر داروهای ضد سرطان در درمان سرطان پستان استفاده کرد.

کلیدواژه‌ها


عنوان مقاله [English]

Effects of the Novel Formulated Forms of Curcumin on Tumor Growth Inhibition in Breast Cancer

نویسندگان [English]

  • Milad Hashemzehi 1
  • Amir Avan 2
  • Maliheh Hasanzadeh 3
  • Soodabeh Shahid Sales 4
  • Zohreh Yousefi 2
  • Sima Kadkhodayan 3
  • Marjaneh Farazestanian 5
  • Mona Joudi Mashhad 6
  • Majid Khazaei 7
  • Seyed Mahdi Hassanian 8
1 PhD Candidate, Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Assistant Professor, Department of Genetics, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate Professor, Department of Oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Assistant Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6 Assistant Professor, Department of Radiation Therapy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7 Professor, Department of Physiology, Neurogenic Inflammation Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8 Assistant Professor, Department of Medical Biochemistry, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده [English]

Introduction: Breast cancer is the most common malignancy and the second leading cause of death due to cancer in women following lung cancer. Ample evidence has shown the antitumor activities of curcumin in breast cancer in preclinical and clinical trials. The anticancer effects of curcumin include the inhibition of cancer cell formation, angiogenesis, and tumor growth. Due to the low absorption of curcumin in the gastrointestinal tract, as well as its low water solubility, rapid metabolism, and high excretion, curcumin has low bioavailability. Therefore, using formulated curcumin could increase its bioavailability. The present study aimed to evaluate the effects of curcumin and its nano-formulated compositions in the prevention and treatment of breast cancer.  
Methods: In this review, data were collected via searching in databases such as PubMed, Scopus, Google Scholar, and Magiran to identify the related English and Persian articles published until 2016 using keywords such as nano-forms, clinical study, cancer, breast, and curcumin. In total, 40 studies were identified and reviewed.  
Results: Using formulated curcumin could increase its absorption and bioavailability, while it also enhances its effects on cancer cells, including breast cancer cells. Therefore, nano-formulated curcumin was observed to be effective in the prevention and treatment of breast cancer.  
Conclusion: Considering the higher bioavailability of the formulated compounds of curcumin compared to its free form and the low toxicity of this herbal medicine, curcumin could be used in combination with other anticancer medications in the treatment of breast cancer.

کلیدواژه‌ها [English]

  • Treatment
  • Breast Cancer
  • Curcumin
  • Clinical Studies
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