The Analgesic Effects of Gabapentin after Total Abdominal Hysterectomy

Document Type : Original Article


1 Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Gilan University of Medical Sciences, Gilan, Iran.

2 Resident of Obstetrics and Gynecology, Faculty of Medicine, Gilan University of Medical Sciences, Gilan, Iran

3 Resident of Anesthetics, Faculty of Medicine, Gilan University of Medical Sciences, Gilan, Iran.

4 M.Sc. of Statistics, Faculty of Medicine, Gilan University of Medical Sciences, Gilan, Iran.

5 Medical Student, Faculty of Medicine, Gilan University of Medical Sciences, Gilan, Iran.

6 General Practitioner, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Introduction: Postoperative pain is a major problem in general surgery which can severely effect on patient. Studies have shown that gabapantin can produce analgesia and reduce the need for opioids in postoperative patients. In this study the efficacy of gabapantin were studied as a premedication for reduce pain and need for opioids in abdominal hysterectomy.
Methods: This double-blind clinical trial was performed in Alzahra maternity of Rasht in 2011. 60 patients who undergo elective abdominal hysterectomy randomly were divided into gabapantin group (1200mg) and placebo group (capsule like gabapantin). Patients visited immediately after recovery and on second and forth hours after surgery in recovery room and VAS was recorded. Data were analyzed with SPSS version 16 by t-student and Mann-Whitney tests.
Results: Age and surgery duration were matched in both groups. VAS was significantly difference in two groups for each of 3 visiting times (p=0.0001). Also the need for petidine was significantly more in control group than case group (p=0.0001).
Conclusion: Administration of gabapantin can reduce postoperative pain and improve sedation after surgery. Gabapantin as a premedication can also reduce need for opioids prescription.


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