Demographic characteristics and body mass index in women with breast fibroadenoma and compare with healthy women referred to Khatam Al-Anbia Clinic in Jahrom in 2019

Document Type : Original Article


1 Assistant Professor, Department of Surgery, Women’s Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

2 B.Sc. in Health, Women’s Health and Diseases Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

3 M.Sc. in Health Services Management, Clinical Research Development Unit of Peymanieh Hospital, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.


Introduction: Benign breast diseases are one of the most common diseases in the females of any society. This study was performed with aim to determine demographic characteristics, history of disease and body mass index in women with benign breast masses and compare it with healthy women referred to Khatam-Al-Anbia Clinic in Jahrom.
Methods: This descriptive cross-sectional study was performed in 2019 with participation of 610 women referred to Khatam-Al-Anbia Clinic in Jahrom. 148 women had fibroadenoma and 467 didn’t have fibroadenoma. Data related to the patients were collected using a questionnaire including individual demographic characteristics and medical records of the referred women. Data were analyzed using the SPSS software (version 21) and descriptive and inferential statistical tests. P<0.05 was considered statistically significant.
 Results: The history of hyperlipidemia was highest in the women with fibroadenoma and without fibroadenoma. In the fibroadenoma group, 29 (29.9%) of women were overweight and 10 (10.3%) were obese, while in the group without fibroadenoma, 125 (43.3%) of women were overweight and 72 (24.9%) were obese. Overweight reduces the chance of developing benign breast masses by 22.2% (95% CI: 0.057-0.836) and obesity reduces the chance of developing benign breast masses by 15.8% (95% CI: 0.036-0.693) and it had a protective effect.
Conclusion: Overweight and obesity reduce the incidence of benign breast diseases. Therefore, it is suggested that the study be performed by adjusting other confounding factors in more extensive level.


  1. Guray M, Sahin AA. Benign breast diseases: classification, diagnosis, and management. The oncologist 2006; 11(5):435-49.
  2. Karki OB, Kunwar D, De A. De A. Benign breast diseases: profile at a teaching hospital. American Journal of Public Health Research 2015; 3(4A):83-6.
  3. Yadava SS, Bishwas NC, Kidwai M. Pattern of breast diseases in breast lump. JNGMC 2003; 3:49-51.
  4. Sayami P, Singh BM, Singh Y, Timila R, Shrestha U, Sayami G, et al. Retrospective analysis of breast cancer cases and surgical treatment in a period of ten years. J Nepal Med Assoc 2001; 40:112-9.
  5. Houssami N, Cheung MN, Dixon JM. Fibroadenoma of the breast. Med J Aust 2001; 174(4):185-8.
  6. Santen RJ, Mansel R. Benign breast disorders. N Engl J Med 2005; 353(3):275-85.
  7. Riedl CC, Luft N, Bernhart C, Weber M, Bernathova M, Tea MK, et al. Triple-modality screening trial for familial breast cancer underlines the importance of magnetic resonance imaging and questions the role of mammography and ultrasound regardless of patient mutation status, age, and breast density. J Clin Oncol 2015; 33(10):1128-35.
  8. Santen RJ. Benign breast disease in women. InEndotext [Internet] 2018.
  9. Ajmal M, Van Fossen K. Breast Fibroadenoma. StatPearls. Treasure Island FL: © 2020, StatPearls Publishing LLC.; 2020.
  10. Sagar A, Iyengar S, Sikarwar S, Mangal KS. Clinical and Histocytological Correlation of Breast Lesions. IOSR-JDMS. 2020;19(5):6-12.
  11. Abhijit MG, Anantharaman D, Sumanth B, Ranjani R. Benign breast diseases: experience at a teaching hospital in rural India. Int J Res Med Sci. 2013; 1(2):73-8.
  12. Berkey CS, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Young women with family history of breast cancer and their risk factors for benign breast disease. Cancer 2012; 118(11):2796-803.
  13. Berkey CS, Willett WC, Frazier AL, Rosner B, Tamimi RM, Colditz GA. Prospective study of growth and development in older girls and risk of benign breast disease in young women. Cancer 2011; 117(8):1612-20.
  14. Chalya PL, Manyama M, Rambau PF, Kapesa A, Ngallaba SE, Masalu N, et al. Clinicopathological pattern of benign breast diseases among female patients at a tertiary health institution in Tanzania. Tanzania Journal of Health Research 2016; 18(1).
  15. Femi AA, Nnaetio OK, Ayedima MM. Profile of Benign Breast Diseases in an African Population. Journal of Surgery 2016; 4(2):35-9.
  16. O'brien S, Kowdley GC. Benign breast diseases and body mass index: is there a correlation? Am Surg 2014; 80(5):461-5.
  17. Worsham MJ, Abrams J, Raju U, Kapke A, Lu M, Cheng J, et al. Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population. Breast J 2007; 13(2):115-21.
  18. Stachs A, Stubert J, Reimer T, Hartmann S. Benign Breast Disease in Women. Dtsch Arztebl Int 2019; 116(33-34):565-574.
  19. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep 2018; 20(2):12.
  20. Sigit FS, Tahapary DL, Trompet S, Sartono E, Willems van Dijk K, Rosendaal FR, et al. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetol Metab Syndr 2020; 12:2.
  21. Webb PM, Byrne C, Schnitt SJ, Connolly JL, Jacobs T, Peiro G, et al. Family history of breast cancer, age and benign breast disease. Int J Cancer 2002; 100(3):375-8.
  22. Ho PJ, Lau HS, Ho WK, Wong FY, Yang Q, Tan KW, et al. Incidence of breast cancer attributable to breast density, modifiable and non-modifiable breast cancer risk factors in Singapore. Scientific reports 2020; 10(1):503.
  23. Bai A, Li H, Huang Y, Liu X, Gao Y, Wang P, et al. A survey of overall life satisfaction and its association with breast diseases in Chinese women. Cancer Med 2016; 5(1):111-9.
  24. Fairbanks F, Andres MP, Caldeira P, Abdo C, Podgaec S. Sexual function, anxiety and depression in women with benign breast disease. A case-control study. Revista da Associação Médica Brasileira 2017; 63(10):876-82.
  25. Kim A, Scharf K, Senthil M, Solomon N, Garberoglio C, Lum SS. The prevalence of overweight and obesity in a breast clinic population: consideration for weight loss as a therapeutic intervention. Surg Obes Relat Dis 2014; 10(2):348-53.
  26. Bhettani MK, Rehman M, Altaf HN, Ahmed SM, Tahir AA, Khan MS, et al. Correlation Between Body Mass Index and Fibroadenoma. Cureus 2019; 11(7):e5219.