Birth Weight of Neonates in Primiparous Mothers across Different Age Groups: A Cross-Sectional Study

Document Type : Original Article

Authors

1 Medical student, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

2 Associate Professor, Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

3 Assistant Professor, Department of Community Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

10.22038/ijogi.2025.71977.5686

Abstract

Introduction: Birth weight is one of the key indicators of neonatal health and a strong predictor of growth, survival, and health in infancy and childhood. Maternal age is considered an important determinant of pregnancy outcomes, and various studies have shown that pregnancies at younger and older ages may be associated with an increased risk of low birth weight. Accordingly, the present study was conducted with aims to compare the birth weight of newborns among primiparous mothers in different age groups.
Methods: In this descriptive-analytical study, the medical records of 200 primiparous mothers with singleton pregnancies were selected through convenience sampling and evaluated in three age groups: under 18 years, 18–35 years, and over 35 years, who had referred to the hospitals affiliated with Islamic Azad University of Tehran during 2021–2022. Required background information such as gestational age, baby's gender, mother's age, mother's body mass index, family income, mother's and father's education, and newborn's birth weight were entered as dependent variables in the prepared checklist. Data were analyzed using SPSS statistical software (version 26) and the t-test, ANOVA, and multiple linear regression analysis. P<0.05 was considered significant.
Results: The highest mean birth weight (3635.7 g) was observed in age group 18-35 years which indicated a more favorable situation in terms of birth weight in this group. The lowest mean birth weight (2360 g) was for mothers under 18 years of age, which is medically considered to be at risk for low birth weight. Mothers over 35 years of age also gave birth to babies with lower birth weights (mean 2551.5 g) than the middle group, which could be related to the risk factors in older age (95% CI: 2718.61-2953.69, p≤0.001). According to the results of the multiple linear regression test, there was a significant relationship between birth weight and maternal age, gestational age, and gender (p<0.05).
Conclusion: Maternal age, gestational age, and the gender of the baby significantly affect birth weight. Specifically, babies born to mothers over 35 years of age have lower birth weights compared to babies born to younger mothers, especially those under 18 to 35 years of age.

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Main Subjects


  1. Kiani Z, Simbar M, Dolatian M, Zayeri F. Correlation between social determinants of health and women’s empowerment in reproductive decision-making among Iranian women. Global journal of health science 2016; 8(9):312.
  2. Taha Z, Ali Hassan A, Wikkeling-Scott L, Papandreou D. Factors associated with preterm birth and low birth weight in Abu Dhabi, the United Arab Emirates. International journal of environmental research and public health 2020; 17(4):1382.
  3. Khan N, Mozumdar A, Kaur S. Determinants of low birth weight in India: An investigation from the National Family Health Survey. American Journal of Human Biology 2020; 32(3):e23355.
  4. Gete DG, Waller M, Mishra GD. Effects of maternal diets on preterm birth and low birth weight: a systematic review. British Journal of Nutrition 2020; 123(4):446-61.
  5. Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. Jama 2020; 324(6):560-70.
  6. Falcão IR, Ribeiro-Silva RD, de Almeida MF, Fiaccone RL, dos S. Rocha A, Ortelan N, Silva NJ, Paixao ES, Ichihara MY, Rodrigues LC, Barreto ML. Factors associated with low birth weight at term: a population-based linkage study of the 100 million Brazilian cohort. BMC pregnancy and childbirth 2020; 20(1):536.
  7. Ghimire U, Papabathini SS, Kawuki J, Obore N, Musa TH. Depression during pregnancy and the risk of low birth weight, preterm birth and intrauterine growth restriction-an updated meta-analysis. Early Human Development 2021; 152:105243.
  8. Khan W, Zaki N, Masud MM, Ahmad A, Ali L, Ali N, et al. Infant birth weight estimation and low birth weight classification in United Arab Emirates using machine learning algorithms. Scientific reports 2022; 12(1):12110.
  9. Li C, Yang M, Zhu Z, Sun S, Zhang Q, Cao J, et al. Maternal exposure to air pollution and the risk of low birth weight: a meta-analysis of cohort studies. Environmental research 2020; 190:109970.
  10. de Mendonça EL, de Lima Macêna M, Bueno NB, de Oliveira AC, Mello CS. Premature birth, low birth weight, small for gestational age and chronic non-communicable diseases in adult life: A systematic review with meta-analysis. Early human development 2020; 149:105154.
  11. Lu C, Zhang W, Zheng X, Sun J, Chen L, Deng Q. Combined effects of ambient air pollution and home environmental factors on low birth weight. Chemosphere 2020; 240:124836.
  12. Yang J, Kingsford RA, Horwood J, Epton MJ, Swanney MP, Stanton J, et al. Lung function of adults born at very low birth weight. Pediatrics 2020; 145(2).
  13. Baye Mulu G, Gebremichael B, Wondwossen Desta K, Adimasu Kebede M, Asmare Aynalem Y, Bimirew Getahun M. Determinants of low birth weight among newborns delivered in public hospitals in Addis Ababa, Ethiopia: Case-control study. Pediatric health, medicine and therapeutics 2020:119-26.
  14. He-xin YU, Ya-hui FE, Yong-le ZH, Ying-jie SH, Yun-li CH, Ya-wen WA, et al. Effects of environmental exposure during pregnancy on preterm birth and low birth weight: a cohort study. Chinese Journal of Disease Control & Prevention 2020; 24(11):1246-51.
  15. Islam S, Mohanty SK. Understanding the association between gradient of cooking fuels and low birth weight in India. SSM-Population Health 2021; 13:100732.
  16. Aher SM, Ohlsson A. Late erythropoiesis‐stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2019(2).
  17. Valadan M, Davari TF, Sepahi A. Pregnancy outcomes in women of advanced maternal age. Journal of Family and Reproductive Health 2011; 5(2):59-63.
  18. Fenton TR, Al-Wassia H, Premji SS, Sauve RS. Higher versus lower protein intake in formula‐fed low birth weight infants. Cochrane database of systematic reviews 2020(6).
  19. Shibata M, Ogawa K, Kanazawa S, Kawasaki M, Morisaki N, Mito A, et al. Association of maternal birth weight with the risk of low birth weight and small-for-gestational-age in offspring: A prospective single-center cohort study. PloS one 2021; 16(5):e0251734.
  20. Yang WC, Fogel A, Lauria ME, Ferguson K, Smith ER. Fast feed advancement for preterm and low birth weight infants: a systematic review and meta-analysis. Pediatrics 2022; 150(Supplement 1):e2022057092G.
  21. Oddie SJ, Young L, McGuire W. Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants. Cochrane database of systematic reviews 2021(8).
  22. Lake EA, Olana Fite R. Low birth weight and its associated factors among newborns delivered at wolaita sodo university teaching and referral hospital, southern Ethiopia, 2018. International journal of pediatrics. 2019; 2019(1):4628301.
  23. Kenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS. Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PloS one 2013; 8(2):e56583.
  24. Wennberg AL, Opdahl S, Bergh C, Henningsen AK, Gissler M, Romundstad LB, et al. Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology. Fertility and sterility 2016; 106(5):1142-9.
  25. Moeindarbari S, Forghani T, Sharif FR. The relationship between BMI and maternal weight gain during pregnancy with birth weight. Iranian Journal of Obstetrics, Gynecology and Infertility 2022; 25(6):12-20.
  26. Mohamadi N, Ahmadinia H, Vazirinejad R, Manshoori A, Ostadebrahimi H, Rezaeian M. Maternal risk factors affecting low birth weight in Rafsanjan township in 2018: A case control study. Journal of Rafsanjan University of Medical Sciences 2020; 19(6):603-18.
  27. Kazemi AS, Mansour GM, Bakhshi M, Bab ES. Comparison of Maternal predictive factors for Underweight between Low Birth and Normal Weight at Al-Zahra Hospital in Rasht in 2018. Journal of Ardabil University of Medical Sciences 2021; 21(1):41-50.
  28. Hidalgo-Lopezosa P, Jiménez-Ruz A, Carmona-Torres JM, Hidalgo-Maestre M, Rodríguez-Borrego MA, López-Soto PJ. Sociodemographic factors associated with preterm birth and low birth weight: A cross-sectional study. Women and Birth 2019; 32(6):e538-43.
  29. Tshotetsi L, Dzikiti L, Hajison P, Feresu S. Maternal factors contributing to low birth weight deliveries in Tshwane District, South Africa. PloS one 2019; 14(3):e0213058.
  30. Tootoonchi P. Low birth weight among newborn infants at Tehran hospitals. Iran J Pediatr 2007; 17(Suppl 2).
  31. Delpisheh A, Brabin L, Attia E, Brabin BJ. Pregnancy late in life: a hospital-based study of birth outcomes. Journal of women's health 2008; 17(6):965-70.
  32. Akbarzadeh M, Zare N. Relationship between maternal hematologic concentration and BMI in primiparous women on some physiological parameters in neonates. Scientific Journal of Iran Blood Transfus Organ 2013; 10(1):77-85.
  33. Başer E, Seçkin KD, Erkılınç S, Karslı MF, Yeral IM, Kaymak O, et al. The impact of parity on perinatal outcomes in pregnancies complicated by advanced maternal age. Journal of the Turkish German Gynecological Association 2013; 14(4):205.
  34. Genowska A, Motkowski R, Strukcinskaite V, Abramowicz P, Konstantynowicz J. Inequalities in birth weight in relation to maternal factors: a population-based study of 3,813,757 live births. International Journal of Environmental Research and Public Health 2022; 19(3):1384.
  35. Jeena PM, Asharam K, Mitku AA, Naidoo P, Naidoo RN. Maternal demographic and antenatal factors, low birth weight and preterm birth: findings from the mother and child in the environment (MACE) birth cohort, Durban, South Africa. BMC pregnancy and childbirth 2020; 20(1):628.
  36. Kyozuka H, Fujimori K, Hosoya M, Yasumura S, Yokoyama T, Sato A, et al. The effect of maternal age at the first childbirth on gestational age and birth weight: The Japan Environment and Children’s Study (JECS). Journal of Epidemiology 2019; 29(5):187-91.
  37. Fall CH, Sachdev HS, Osmond C, Restrepo-Mendez MC, Victora C, Martorell R, et al. Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). The Lancet Global Health 2015; 3(7):e366-77.
  38. Guimarães AM, Bettiol H, Souza LD, Gurgel RQ, Almeida ML, Ribeiro ER, et al. Is adolescent pregnancy a risk factor for low birth weight?. Revista de saude publica 2013; 47:11-9.
  39. Eminov E, Eminov A. Prevalence of adolescent pregnancy and evaluation of pregnancy outcomes: a retrospective study. Archives of Gynecology and Obstetrics 2025; 311(5):1351-8.
  40. Plasencia AV, Castellanos L, Forster VR, Ruiz-Pelaez J. The Association Between Teenage Pregnancy and the Development of Asthma in Children Aged Zero to Five Years. Cureus 2025; 17(7).