The Effect of Persicaria Hydropiper Vaginal Cream on Sexual Function of Postmenopausal Women

Document Type : Original Article

Authors

1 M.Sc. Student of Midwifery, School of Nursing and Midwifery, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran.

2 Associate Professor, Department of Midwifery, Menopause Research Center, School of Nursing and Midwifery, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran.

3 Professor, Department of Pharmaceutics, Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Assistant Professor, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

10.22038/ijogi.2025.84506.6288

Abstract

Introduction: Decreasing estrogen levels during menopause cause changes in the tissues of the reproductive system. Sexual dysfunction is a common problem in menopausal women. This study was conducted with aim to investigate the effect of Persicaria hydropiper vaginal cream on sexual function in menopausal women.
Methods: This double-blind clinical trial study was conducted in 2024 on 111 postmenopausal women aged 45-65 years in Ahvaz city. Subjects were divided into three groups: Persicaria hydropiper vaginal cream based on coconut and sesame oil, placebo, and conjugated estrogen, and were treated for 12 weeks. Visits were made at weeks 8, 12, and 4 after the end of treatment. Female Sexual Function Index was used to collect data. Data were analyzed using SPSS software (version 25) and Shapiro-Wilk test, chi-square, one-way analysis of variance, and repeated-measures analysis of variance. P < 0.05 was considered significant.
Results: After treatment, the women sexual function score in the Persicaria hydropiper group significantly increased compared to the placebo group (P<0.0001), but no statistically significant difference was observed compared to the conjugated estrogen group (P>0.05).
Conclusion: Persicaria hydropiper vaginal cream is as effective as standard treatment in improving sexual function and its dimensions in menopausal women. Therefore, it can be considered as a non-hormonal alternative treatment for improving the aforementioned disorder.

Keywords

Main Subjects

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 6
August 2025
Pages 51-65

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