Effect of Pethidine (Meperidine) on decreasing the duration of First and Second Stages of Labor

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, Children Growth Research Center, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

2 Associate Professor, Department of Community Medicine, Children Growth Research Center, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

3 Gynecologist, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

4 General practitioner, Metabolic Diseases Research Center, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Abstract

Introduction: Pethedine is used to decrease labor pain. According to some studies, pethidine can be effective on labor progress. This study was performed with aim to determine the effect of pethidine on decreasing the duration of the first and second stages of labor.
Methods: This clinical trial was performed on 120 nulliparous women with term singleton pregnancy who needed induction of labor for pregnancy termination in Kosar hospital, Qazvin in 2013. They were randomly assigned in two groups of intervention and control (n=60). A single dose of 50 mg pethidine was injected intravenously at 4 cm cervical dilatation in intervention group. In control group, normal saline was injected as placebo. The intervals between the injection and complete cervical dilatation, the complete cervical dilatation and the end of delivery, and the injection and the end of delivery were measured. Data were analyzed by SPSS software (version 19) and student T-test and Chi-square test P< 0.05 was considered significant.
Results: The mean interval between the injection of pethedine and complete cervical dilatation was 129±70 min in intervention group and 133±75 min in control group and the difference was not statistically significant (P=0.7). The mean duration of second stage of labor was 45±26 min in intervention group and 41±16 min in control group and the difference was not statistically significant (P=0.3). The mean interval between pethidine injection and end of delivery was 175±79 min in intervention group and 174±83 min in control group and the difference was not statistically significant (P=0.39).
Conclusions: There is no significant relationship between pethidine injection and progression of the labor stages.

Keywords

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 19, Issue 39
February 2017
Pages 1-7

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