Clinical Manifestations, Laboratory Results and Clinical Outcome in Six Pregnant Women with Crimean-Congo Hemorrhagic Fever

Crimean-Congo Hemorrhagic Fever (CCHF) is caused by Nairovirus, genus Bunyavirus in the family of bunyaviridae, and is spread by the tick Hyalomma spp or via blood transfusion and contaminated blood of humans and animals. In recent years, disease has been reported from Iran, specially from Sistan and Baluchistan, Isfahan, Kermanshah and Kohkilouyeh-Bouyerahmad Provinces. Now, CCHF is endemic in Sistan and Baluchistan provinces. There are several epidemiological reports about CCHF from Iran and other countries, but there was no survey about CCHF and Pregnant women. In order to study the clinical manifestations, laboratory results and prognosis of CCHF during pregnancy, this study was conducted.
Herein, we report six pregnant women with CCHF, who were admitted to 
Boo-Ali Hospital in a time period of 5 years from 2000 to 2005. All Patients were treated by Ribavirin. We studied the clinical manifestations-laboratory results and clinical outcome of disease in all cases.
 
Our results showed that, fever, headache, myalgia and gum bleeding were the most common clinical manifestations. Thrombocytopenia-anemia and decreasing of prothrombin time were the commonest laboratory results. Abortion was observed in 3 patients and stillbirth in one patient. In fact, 66.6% of pregnant women had fetal loss. It is found that fetal loss is high in this disease, but it more studies, especially in endemic areas, should be done.