The Effect of Aspirin at Doses of 80 and 160 mg on Prevention of Preeclampsia in Women with Abnormal Uterine Artery Doppler Ultrasound

Document Type : Original Article

Authors

1 Gynecologist, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

2 Assiatant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

3 M.Sc. of Biostatistics, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

4 M.Sc. of Counseling in Midwifery, Deputy of Treatment, Sabzevar University of Medical Sciences, Sabzevar, Iran.

5 M.Sc. of Midwifery Education, Deputy of Treatment, Sabzevar University of Medical Sciences, Sabzevar, Iran.

6 Assistant Professor, Department of Perinatology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

10.22038/ijogi.2026.82348.6192

Abstract

Introduction: Preeclampsia is caused by inadequate perfusion of the placental body due to inadequate regeneration of the spiral arteries of the uterine body. Early diagnosis and treatment with aspirin can prevent the occurrence of preeclampsia (PE) and fetal and maternal complications. The present study was conducted with aim to compare the effectiveness of high and low dose aspirin in the prevention of preeclampsia in pregnant mothers with impaired Doppler.
Methods: This double-blind, randomized, placebo-controlled, parallel-group trial was conducted in the Sabzevar Perinatology Clinic during 2001-2002. A total of 300 women with singleton pregnancies and abnormal uterine artery Doppler on ultrasound performed in the first trimester, before 22 weeks, were enrolled in the study. The intervention consisted of daily high-dose aspirin (160 mg) or low-dose aspirin (80 mg) until 36 weeks of gestation. Pregnancy outcomes were compared in the two groups using the Mann-Whitney and Chi-square tests.
Results: The incidence of mild preeclampsia was reported in 8 patients (5.4%) and severe preeclampsia in 4 (2.7%) in the high-dose group, compared to 3 patients (2.0%) with mild preeclampsia (p=0.13) and 1 (0.7%) with severe preeclampsia (p=0.18) in the low-dose group. In the high-dose group, 12 patients (8.1%) had intrauterine growth restriction (IUGR), 39 (26.4%) had preterm labor, and 22 (14.9%) had high blood pressure. In the low-dose aspirin group, these rates were 6 patients (4.0%) (p=0.10), 27 (18.0%) (p=0.055), and 16 (10.7%) (p=0.055), respectively. Mean of infant weight was 3102.46±509.47 in the high-dose group versus 3064.68±437.6 in the low-dose group (p=0.3).
Conclusion: Low-dose aspirin (80 mg) compared to high-dose aspirin (160 mg) before 22 weeks of gestation in women with abnormal uterine artery Doppler findings has the same effect in preventing preeclampsia, preterm delivery, intrauterine growth restriction, hypertension, and infant weight.

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References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 12
February 2026
Pages 17-26

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