The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Primary ovarian non-Hodgkin's lymphoma: a case report

Document Type : Case report

Authors
Marjaneh Farazestanian 1
Malihe Rakhshanifar 2
Zohreh Yousefi 3
Malihe Hasanzadeh 3
Fatemeh Homaee 4
Amir Hosein Jafarian 5
Behrooz Davachi 6
Helena Azimi 7
Sareh Hosseini 8
Maryam Nakhaee 9
Alireza Ghodsi 10
Bahram Hamidi 11
Somayeh Moein Darbari 7
1 Assistant professor, Department of Obstetrics and Gynecology, Fellowship of Gynecology Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Professor, Department of Obstetrics and Gynecology, Fellowship of Gynecology Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 professor, Department of Radiotherapy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Associate professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6 Associate professor, Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7 Assistant professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8 Assistant professor, Department of Rdiotherapy and Oncology, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9 Fellowship of Gynecology Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
11 Student of Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijogi.2020.17395
Abstract
Introduction: Non-Hodgkin's lymphoma in the genital system is uncommon and ovary is one of the most common sites of involvement. Ovarian involvement in non-hodgkin's lymphoma is often secondary and is a part of the systemic involvement. Primary and localized ovarian involvement is uncommon and occurs in less than 10% of cases. In this study, a rare case of primary ovarian non-Hodgkin's lymphoma is presented.
Case presentation: The patient was a 64-year-old woman with a history of hysterectomy and postmenopausal bleeding that referred to the academic hospital of Mashhad University of Medical Sciences. On ultrasound and CT scans, solid cystic foci were found between the bladder and rectum, consistent with the location of the cervix and uterus. Subsequent evaluations confirmed histological and immunohistochemical diagnosis of ovarian non-Hodgkin's lymphoma.
Conclusion: Ovarian lymphoma is one of the differential diagnoses that should be considered in the pelvic masses.
Keywords
Non-Hodgkin's lymphoma
Uterine bleeding
Hysterectomy
Pelvic neoplasm
  1. Bradshaw G, Sutherland HG, Haupt LM, Griffiths LR. Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma. Genes (Basel) 2016; 7(12):130.
  2. Perry AM, Diebold J, Nathwani BN, MacLennan KA, Müller-Hermelink HK, Bast M, et al. Non-Hodgkin lymphoma in the developing world: review of 4539 cases from the International Non-Hodgkin Lymphoma Classification Project. Haematologica 2016; 101(10):1244-1250.
  3. Vang R, Medeiros LJ, Fuller GN, Sarris AH, Deavers M. Non-Hodgkin's lymphoma involving the gynecologic tract: a review of 88 cases. Adv Anat Pathol 2001; 8(4):200-17.
  4. Vang R, Medeiros LJ, Warnke RA, Higgins JP, Deavers MT. Ovarian non-Hodgkin's lymphoma: a clinicopathologic study of eight primary cases. Mod Pathol 2001; 14(11):1093-9.
  5. Taskin MI, Gokgozoglu L, Kandemir B. Primary ovarian large B-cell lymphoma. Case Reports in Obstetrics and Gynecology 2013; 2013.
  6. Senol T, Doger E, Kahramanoglu I, Geduk A, Kole E, Yucesoy I, et al. Five cases of non-hodgkin B-cell lymphoma of the ovary. Case reports in obstetrics and gynecology 2014; 2014.
  7. Bhartiya R, Kumari N, Mallik M, Singh RV. Primary Non-Hodgkin's Lymphoma of the Ovary - A Case Report. J Clin Diagn Res 2016; 10(5):ED10-1.
  8. Yadav R, Sharma MC, Karak AK, Agarwal N, Kumar R, Kumar L. Natural history of primary precursor B lymphoblastic lymphoma of the ovary: report of a rare case. J Obstet Gynaecol Res 2013; 39(2):611-6.
  9. Mandato VD, Palermo R, Falbo A, Capodanno I, Capodanno F, Gelli MC, et al. Primary diffuse large B-cell lymphoma of the uterus: case report and review. Anticancer Res 2014; 34(8):4377-90.
  10. Armitage JO. Staging non-Hodgkin lymphoma. CA Cancer J Clin 2005; 55(6):368-76.
  11. Weingertner AS, Hamid D, Roedlich MN, Baldauf JJ. Non-Hodgkin malignant lymphoma revealed by an ovarian tumor case report and review of the literature. Gynecol Oncol 2004; 95(3):750-4.
  12. Krasniqi A, D'Huyvetter M, Xavier C, Van der Jeught K, Muyldermans S, Van Der Heyden J, et al. Theranostic Radiolabeled Anti-CD20 sdAb for Targeted Radionuclide Therapy of Non-Hodgkin Lymphoma. Mol Cancer Ther 2017; 16(12):2828-2839.
  13. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 2014; 32(27):3059-68.
  14. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK, et al. Non-Hodgkin lymphoma and Hodgkin disease: coregistered FDG PET and CT at staging and restaging--do we need contrast-enhanced CT? Radiology 2004; 232(3):823-9.
  15. Onea AS, Jazirehi AR. CD19 chimeric antigen receptor (CD19 CAR)-redirected adoptive T-cell immunotherapy for the treatment of relapsed or refractory B-cell Non-Hodgkin's Lymphomas. Am J Cancer Res 2016; 6(2):403-24.
  16. Homaee Shandiz F, Emadi Torghabeh A, Yousefi Z, Sharifi N, Jafarian AH, Dehghan P, et al. Primary non-Hodgkin ovarian lymphoma: a case report. Iran J Obstet Gynecol Infertil 2014; 17(112):15-9.
  17. Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, Holcomb K. Primary lymphoma of the female genital tract: an analysis of 697 cases. Gynecologic Oncology 2017; 145(2):305-9.
  18. Dann EJ, Epelbaum R, Avivi I, Ben Shahar M, Haim N, Rowe JM, et al. Fertility and ovarian function are preserved in women treated with an intensified regimen of cyclophosphamide, adriamycin, vincristine and prednisone (Mega-CHOP) for non-Hodgkin lymphoma. Hum Reprod 2005; 20(8):2247-9.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 23, Issue 9
November 2021
Pages 108-112