Prevalence of neuropathic pain and factors affecting sleep quality in women with breast cancer after radiotherapy

Document Type : Original Article

Authors

1 M.Sc. in Nursing, Tuberculosis and Lung Disease Research Center, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

2 BC student in Anesthesia, School of Paramedical, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Gynecologist, Faculty of Medicine and Paramedical, Ardabid University of Medical Sciences, Ardabil, Iran.

4 Fellowship of Gynecology Oncology, Faculty of Medicine and Paramedical, Ardabid University of Medical Sciences, Ardabil, Iran.

Abstract

Introduction: Neuropathic pain can be one of the main causes of decreased sleep quality, and undesirable sleep quality has negative effects on quality of life and treatment continuation. This study was performed with aim to evaluate neuropathic pain and factors affecting sleep quality in women with breast cancer after radiotherapy.
Methods: This descriptive-correlational study was performed from 21March 2017 to 20February 2019 on women with breast cancer undergoing radiotherapy in Imam Reza Educational Center, Tabriz University of Medical Sciences. The tools included demographic characteristics, VAS pain questionnaire, and Pittsburgh Sleep Disorders Questionnaire which measured neuropathic pain and sleep status. Data was analyzed by SPSS software (version 20) and multivariate regression test. P <0.05 was considered statistically significant.
Results: Mean of pain severity in patients participating in the study was 06.55±1.03 and mean score of sleep was 12.29±3.20. According to regression results, the variables of age (P=0.012), pain intensity (P=0.001), mastectomy (P=0.011), lymph nodes removal (P=0.03), number of radiotherapy sessions (P=0.003), history of chemotherapy (P=0.002) and stage of disease (P=0.01) significantly predicted sleep disorder.
Conclusion: Prevalence of neuropathic pain after radiotherapy in women with breast cancer was high in this study, and this pain was the predictor of sleep disorder in these women.

Keywords

References

  1. Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain 2016; 157(8):1599-606.
  2. Sant M, Chirlaque Lopez MD, Agresti R, Sánchez Pérez MJ, Holleczek B, Bielska-Lasota M, et al. Survival of women with cancers of breast and genital organs in Europe 1999–2007: results of the EUROCARE-5 study. Eur J Cancer 2015; 51(15):2191-205.
  3. Pereira S, Fontes F, Sonin T, Dias T, Fragoso M, Castro-Lopes J, et al. Neuropathic pain after breast cancer treatment: characterization and risk factors. J Pain Symptom Manage 2017; 54(6):877-88.
  4. Fontes F, Gonçalves M, Pereira S, Lunet N. Neuropathic pain after breast cancer treatment and its impact on sleep quality one year after cancer diagnosis. Breast 2017; 33:125-31.
  5. Khasraw M, Posner JB. Neurological complications of systemic cancer. Lancet Neurol 2010; 9(12):1214-27.
  6. Fallon M. Neuropathic pain in cancer. Br J Anaesth 2013; 111(1):105-11.
  7. Golan‐Vered Y, Pud D. Chemotherapy‐induced neuropathic pain and its relation to cluster symptoms in breast cancer patients treated with paclitaxel. Pain Pract 2013; 13(1):46-52.
  8. Otte JL, Carpenter JS, Russell KM, Bigatti S, Champion VL. Prevalence, severity, and correlates of sleep-wake disturbances in long-term breast cancer survivors. J Pain Symptom Manage 2010; 39(3):535-47.
  9. Dahiya S, Ahluwalia MS, Walia HK. Sleep disturbances in cancer patients: underrecognized and undertreated. Cleve Clin J Med 2013; 80(11):722-32.
  10. Belfer I, Schreiber KL, Shaffer JR, Shnol H, Blaney K, Morando A, et al. Persistent postmastectomy pain in breast cancer survivors: analysis of clinical, demographic, and psychosocial factors. J Pain 2013; 14(10):11185-95.
  11. Jensen MP, Chang HY, Lai YH, Syrjala KL, Fann JR, Gralow JR. Pain in long-term breast cancer survivors: frequency, severity, and impact. Pain Med 2010; 11(7):1099-106.
  12. Denieffe S, Cowman S, Gooney M. Symptoms, clusters and quality of life prior to surgery for breast cancer. J Clin Nurs 2014; 23(17-18):2491-502.
  13. Cleeland C, Ryan K. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore 1994; 23(2):129-38.
  14. Alireza H, Parvin E, M Mandana. Relationship between insomnia, sleep quality, drowsiness and psychological health dysfunction with educational function in girls. Women and Culture. 2010;2(4):65-76.
  15. Haghani H. The relationship between academic procrastination, academic achievement, and self-efficacy in nursing students of Tehran University of Medical Sciences. Iran J Med Educ 2014; 14(1):32-40.
  16. Fontes F, Severo M, Gonçalves M, Pereira S, Lunet N. Trajectories of sleep quality during the first three years after breast cancer diagnosis. Sleep Med 2017; 34:193-9.
  17. Zomorrodi A, Mohammadipoor Anvari H, Kakaei F, Solymanzadeh F, Khanlari E, Bagheri A. Bolus injection versus infusion of furosemide in kidney transplantation: a randomized clinical trial. Urol J 2017; 14(2):3013-7.
  18. Movassaghi R, Peirovifar A, Aghamohammadi D, Anvari HM, Golzari SE, Kourehpaz Z. Premedication with single dose of acetazolamide for the control of referral shoulder pain after laparoscopic cholecystectomy. Anesthesiol Pain Med 2015; 5(6):e29366.
  19. Bakhshaei MH, Manuchehrian N, Khoshraftar E, Mohamadipour-Anvary H, Sanatkarfar M. Analgesic effects of intrathecal sufentanil added to lidocaine 5% in elective cesarean section. Acta Med Iran 2010; 48(6):380-4.
  20. Aghamohammadi D, Eidi M, Lotfi A, Hosseinzadeh H, Movasaghi R, Motighini N, et al. Effect of low level laser application at the end of surgery to reduce pain after tonsillectomy in adults. J Lasers Med Sci 2013; 4(2):79-85.
  21. Hosseinzadeh H, Golzari SE, Abravesh M, Mahmoodpoor A, Aghamohammadi D, Zomorrodi A, et al. Effect of low dose dopamine on early graft function in living unrelated kidney donors. Urol J 2012; 9(1):389-96.
  22. Vahedi P, Salehpour F, Aghamohammadi D, Shimia M, Lotfinia I, Mohajernezhadfard Z, et al. Single dose preemptive amitriptyline reduces postoperative neuropathic pain after lumbar laminectomy and discectomy: a randomized placebo-controlled clinical trial. Neurosurg Quart 2010; 20(3):151-8.
  23. Aghaei Bahmanbeglou N, Khosrow E, Ahmadizad S, Maleki M, Nikpajouh A. Comparison of Acute and Chronic Responses of Blood Pressure, Pulse Wave Velocity, and Ankle-brachial Index to Two Different High-intensity Interval Training Protocols. Medical J Mashhad University of Medical Sciences. 2017;60(3):539-48.
  24. Rad AH, Azizi A, Darghahi R, Bakhtiari O, Javadi M, Moghaddam MJ, et al. Development of Synbiotic Milk Chocolate Enriched with Lactobacillus paracasei, D-tagatose and Galactooligosaccharide. Appl Food Biotechnol, 2018;5(2):59-68.
  25. Mobaraki N, Yousefian M, Seifi S, Sakaki M. A randomized controlled trial comparing use of enthonox with pethidine for pain relief in primigravid women during the active phase of labor. Anesth Pain Med. 2016; 6(4): e37420.
  26. Dargahi R, Shahbazzadegan S, Naghizadeh-Baghi A, Sefati Kooyakhi S. Expression levels of Drosha and Dicer enzymes and DGCR8 protein in pre-eclamptic patients. Iran J of Obstet, Gynecol Infertil. 2018;20(12):40-9.
  27. Rasooli S, Moslemi F, Golzari SE. Intraperitoneal Bupivacaine-Meperidine Infiltration Versus Intravenous Paracetamol: A Comparison of Analgesic Efficacy in Post-Gynecologic Diagnostic Laparoscopic Pain. Anesth Pain Med. 2015;5(3): e26414.
  28. Rasooli S, Parish M, Mahmoodpoor A, Moslemi F, Sanaie S, Faghfuri S. The effect of intramuscular ephedrine in prevention of hypotension due to propofol. Pak J Med Sci. 2007;23(6):893-97.
  29. Navali N, Azhary Shokoufe L, Mallah F, Bastani P, Mashrabi O. Comparing therapeutic effects of Metformin and Pioglitazone in Polycystic ovary syndrome (PCOS). Pak J Med Sci. 2012; 28 (3): 390-4.
  30. Mallah F, Nazari F, Navali N, Hajipour B. Comparison of direct visual inspection (DVI) with pap smear in diagnosis of precancerous lesion of cervix. Life Science Journal. 2012;9(4):2556-60.
  31. Mallah F, Tasbihi P, Navali N, Azadi A. Urinary incontinence during pregnancy and postpartum incidence, severity and risk factors in Alzahra and Taleqani hospitals in Tabriz, Iran, 2011-2012. Int J Women’s Health Reproduction Sci. 2014; 2 (3): 178-85.
  32. Bastani P, Shoari N, HAJEBRAHIMI S, Mallah F, Azadi A. Comparison of performing and not-performing the prophylactic surgery for urinary incontinence in advanced pelvic organ prolapse. Int J Women’s Health Reproduction Sci. 2014; 2 (5): 311–15.
  33. Ziyadi S, Bastani P, Homayouni A, Mohammad-Alizadeh-Charandabi S, Mallah F. Probiotics and usage in urinary tract infection. Probiotics prebiotics and synbiotics: Bioactive foods in health promotion Elsevier Inc, London. 2016:827-30.
  34. van den Beuken-van MH, Hochstenbach LM, Joosten EA, Tjan-Heijnen VC, Janssen DJ. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manage 2016; 51(6):1070-90.
  35. Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, et al. Neuropathic pain. Nat Rev Dis Primers 2017; 3:17002.
  36. Mañas A, Monroy JL, Ramos AA, Cano C, López-Gómez V, Masramón X, et al. Prevalence of neuropathic pain in radiotherapy oncology units. Int J Radiat Oncol Biol Phys 2011; 81(2):511-20.
  37. Argoff CE. The coexistence of neuropathic pain, sleep, and psychiatric disorders: a novel treatment approach. Clin J Pain 2007; 23(1):15-22.
  38. Mirghaforvand M, Mohammad-Alizadeh-Charandabi S, Zarei S, Effati-Daryani F, Sarand FS. The relationship between depression and sleep quality in Iranian pregnant women. Int J Womens Health Reprod Sci 2017; 5:147-52.
  39. Boakye PA, Olechowski C, Rashiq S, Verrier MJ, Kerr B, Witmans M, et al. A critical review of neurobiological factors involved in the interactions between chronic pain, depression, and sleep disruption. Clin J Pain 2016; 32(4):327-36.
  40. Fotouhi A, Hashemi H, Shariati M, Emamian MH, Yazdani K, Jafarzadehpur E, et al. Cohort profile: shahroud eye cohort study. Int J Epidemiol 2013; 42(5):1300-8.
  41. Salarinia F, Bani S, Jafarabadi MA, Hasanpoor S, Abasalizadeh S, Ansari K. Relationship between sleep quality and overweight and obesity in women of reproductive age referred to health centers in Yazd. Mortality 2017; 4:6.
  42. Shafaie FS, Nagizadeh S, Valizadeh S. Breast cancer screening tests in Tabriz Behbood hospital. Int J Women Health Reprod Sci 2016; 4:134-40.
  43. Baradaran B, Hajiasgharzadeh K. Breast cancer among young women in Iran. Int J Womens Health Reprod Sci 2019; 7(2):140.
  44. Najafi T. Chemotherapy-induced oxidative stress and infertility. Int J Womens Health Reprod Sci 2017; 5(2):80-1.
  45. Nijs J, Leysen L, Pas R, Adriaenssens N, Meeus M, Hoelen W, et al. Treatment of pain following cancer: applying neuro-immunology in rehabilitation practice. Disabil Rehabil 2018; 40(6):714-21.
  46. Sansone P, Pace MC, Passavanti MB, Pota V, Colella U, Aurilio C. Epidemiology and incidence of acute and chronic Post-Surgical pain. Ann Ital Chir 2015; 86(4):285-92.
  47. Roberto A, Deandrea S, Greco MT, Corli O, Negri E, Pizzuto M, et al. Prevalence of neuropathic pain in cancer patients: pooled estimates from a systematic review of published literature and results from a survey conducted in 50 Italian palliative care centers. J Pain Symptom Manage 2016; 51(6):1091-102.e4.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 22, Issue 6
August 2019
Pages 46-53

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