Serum values of glutathione, paraoxonase and myeloperoxidase in women with gestational diabetes mellitus compared with normal pregnant women in Khorramabad during 2014-2015

Document Type : Original Article


1 Associate professor, Department of Biochemistry and Genetics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

2 Professor, Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.


Introduction: Oxidative stress plays an important role in the development of gestational diabetes mellitus (GDM). Overproduction of reactive oxygen species can result in serious cellular damages which can lead to important complications for mother and fetus. This study was performed with aim to investigate serum values of glutathione, paraoxonase and myeloperoxidase in GDM compared with normal pregnancy.
Methods: This case-control study was performed on 30 women with GDM and 30 normal pregnant women referred to Asalian hospital of Khorramabad, Iran during 2014-2015. Two groups were matched in terms of age, gestational age and body mass index. The subjects were selected using convenience sampling method. Serum values of glutathione were measured by ELISA method and values of paraoxonase and myeloperoxidase were evaluated by colorimetric methods. Data were analyzed by SPSS software (version 19) and Independent t-test and logistic regression test. PResults: Fasting blood glucose was significantly increased in GDM compared with normal pregnancy (p<0.001). Serum levels of glutathione were significantly decreased in women with GDM compared with normal pregnant women (p=0.030). There were no significant differences in paraoxonase (p=0.225) and myeloperoxidase (p=0.602) activities between two groups. The results of logistic regression test showed that glutathione was significantly a negative risk factor for GDM and could have a protective role against GDM (p=0.045).
Conclusion: In the current study, serum levels of glutathione were significantly decreased in GDM compared with normal pregnancy.


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