The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Association of Pregnancy-Associated Plasma Protein A (PAPP-A) and Gestational Diabetes

Authors
Somayeh Ramezani 1
Mahboubeh Ahmadi 2
Hamid Saqhafi 3
Mahmood Alipoor 4
1 M.Sc. student of Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 PHD, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 PHD of Laboratory Sciences, Faculty of Paramedical, Qazvin University of Medical Sciences, Iran.
4 Assistant professor, Department of Biostatistics, Faculty of Medicine, Qazvin University of Medical Sciences, Iran.
10.22038/ijogi.2017.8625
Abstract
Introduction: Gestational diabetes mellitus is the most common medical complication during pregnancy that negatively affects the health of mother and fetus and neonate. Gestational diabetes mellitus occurs in 3-5% of pregnancies. Early detection of gestational diabetes can prevent of these complications. This study was performed with aim to determine the association between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes to detect a risk factor for predicting gestational diabetes.
Methods: This prospective analytical study was performed on 250 pregnant women referring to six healthcare centers of Qazvin from February to October 2016. PAPP-A was measured at 11-14 gestational weeks, then 75 gr glucose tolerance test was performed on the samples at 24-27 gestational weeks. The association between gestational diabetes and PAPP-A was studied. Data were analyzed by SPSS software (version 21) and Chi-square, t-test, Mann-Whitney, relative risk, and logistic regression. PResults: Twenty-four subjects (30.8%) of patients with decreased PAPPA and 15 (8.7%) of patients with normal PAPP-A were diagnosed with gestational diabetes. Chi-square test showed significant difference between two groups based in terms of gestational diabetes (P<0.001). The risk of gestational diabetes in the patients with decreased PAPP-A was 3.90 times more than control group (CI=1.87-8.14, P<0.001)
Conclusion: Low level of PAPP-A at gestation weeks of 11-14 can be a possible risk factor for the incidence of gestational diabetes. Therefore, it can be used as an early detection test for preventing the fetal and maternal adverse effects.
Keywords
Gestational diabetes
Pregnancy-Associated Plasma Protein A
pregnancy
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 20, Issue 1
April 2017
Pages 61-69