Assessment of effective factors on prognosis of breast cancer patients

Document Type : Original Article

Authors

1 Assistant Professor, Department of Obstetrics & Gynecology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

2 Associate Professor, Department of Radiation Oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Radiotherapist-oncologist, Reza Radiation Oncology Center, Mashhad, Iran.

4 Student of Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

5 PhD student of Medical Genetic, Medical Genetic Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: According to recent epidemiologic studies, the prevalence of breast cancer is growing in our country and has become a great concern for the researchers. Various studies in different regions and populations reported variable prognostic factors influencing on patients' survival. This study was performed with aim to evaluate the effective factors on prognosis of breast cancer patients in five-year period.
Methods: In this cross-sectional study, the information of all female breast cancer patients who had referred to Reza Radiation Oncology Center of Mashhad from 2007 to 2011were evaluated and the effect of different variables (include age, pathologic type, hormone receptors (ER,PR), and Her2 expression) on their survival was evaluated. Data was analyzed with SPSS software (version 18) and cox regression test and survival analysis. P<0.05 was considered significant.
Results: Mean age of breast cancer patients was 49.13±11.57. Mean overall survival of patients younger than 48 years was 51.96 months and for those who were older than 48 years was 52.93 months that there was no significant difference between two groups (P=0.336). Cancer stage was significantly affected on overall survival and it was found that whatever the cancer stage is increased, the rate of overall survival is decreased (P=0.000). Overall survival significantly decreased with increased estrogen receptor expression (P=0.000).
Conclusion: Due to significant impact of clinical stage and estrogen receptor expression on patients' survival rates, as well as achieving the median age of about 48 years in patients, screening and identification of patients with poor prognostic factor in this age group it seems to be necessary.

Keywords

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 19, Issue 39
February 2017
Pages 18-24

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